The invention discloses an echo cancellation system, method, device and equipment and a computer readable storage medium. The system includes a signal processing module, a power amplifier module, a loudspeaker, a signal processing module and a sound collection module. The signal processing module is connected with the power amplifier module and used for transmitting a first playing signal to the power amplifier module, the power amplifier module is connected with the loudspeaker and used for receiving the transmitted first playing signal, processing the first playing signal to generate a second playing signal, and transmitting the second playing signal to the loudspeaker and the signal processing module, the loudspeaker is used for receiving and playing the second playing signal, the signal processing module is used for receiving and storing the second playing signal, the sound collection module is connected with the signal processing module and used for collecting the sound signal andtransmitted the sound signal to the signal processing module, the signal processing module is used for receiving the sound signal, the sound signal is subjected to noise reduction treatment accordingto the second playing signal, an echo cancellation signal is generated, and thoroughness of the echo cancellation is ensured.