Surface nanocrystallization method for hydroxyapatite coating

A hydroxyapatite, nanotechnology, applied in chemical instruments and methods, coatings, nanotechnology, etc., can solve problems that are not conducive to the interface bonding strength and long-term stability, lose the function of shielding the release of harmful ions, and the technical solution is not yet available. See reports and other issues to achieve the effects of being suitable for large-scale production, excellent biocompatibility, and firm binding

Inactive Publication Date: 2007-11-14
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dissolution and degradation speed of the amorphous phase and the decomposed phase are much higher than that of hydroxyapatite. Although some people think that this is beneficial to the bone formation on the implant surface, if the dissolution speed and the bone formation speed of the coating surface cannot be well matched, lead to implant loosening and failure
Moreover, the faster dissolution and degradation rate will cause the coating to disappear prematurely, so that it loses its role in shielding harmful ion release
Secondly, according to reports by Gross K A and Berndt C C (JBiomed Mater Res.1998, 39:407-14) et al., there is a distribution gradient of the amorphous phase and decomposed phase in the coating, that is, there is less on the coating surface and less on the coating surface. There are many interfaces between the coating and the substrate, which is very detrimental to the interface bonding strength and long-term stability after the coating is implanted
Crystallization by heat treatment after spraying can improve the crystallinity of the coating, but because there are more amorphous phases and decomposed phases at the interface, the phase change and volume shrinkage during the crystallization process will also lead to a decrease in the interface strength
[0003] Combining the process characteristics of plasma spraying and the performance requirements of the coating in clinical use, by changing the phase distribution and surface state in the coating, and simultaneously obtaining a new surface bionic structure, the above problems can be comprehensively solved. However, related technical solutions in this regard After searching, there is no report so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) The first layer of hydroxyapatite coating with a thickness of 30-35 microns is prepared by plasma spraying with medical pure titanium as the matrix; the particle size of the hydroxyapatite powder is 38-45 microns, and the spraying power is 25kW , the plasma gas is argon gas and hydrogen gas (volume mixing ratio is 40:12), the spraying distance is 80-100 mm, and the powder feeding rate is 20-30 grams per minute;

[0019] (2) Repeat the above operation, during the operation, by using two spray guns to maintain the continuity of the spraying of the first layer and the second layer, a second layer of hydroxyapatite coating with a thickness of 20-25 microns is prepared on the surface of the first layer coating. layer; the particle size of the hydroxyapatite powder is 10-38 microns, and the spraying power is 30kW;

[0020] (3) Crystallization of the coating: the above-mentioned coating was raised from room temperature to 700° C. under the atmospheric environment, and kept...

Embodiment 2

[0022] (1) The first layer of hydroxyapatite coating with a thickness of 55-60 microns was prepared by plasma spraying with medical Ti6Al4V as the matrix; the particle size of the hydroxyapatite powder was 75-106 microns, and the spraying power was 35kW, The plasma gas is argon gas and hydrogen gas (volume mixing ratio is 40:12), the spraying distance is 90-100 mm, and the powder feeding rate is 20-30 grams per minute;

[0023] (2) Repeat the above-mentioned operation, by using two spray guns to maintain the continuity of the spraying of the first layer and the second layer, and prepare a second layer of hydroxyapatite coating with a thickness of 35-40 microns on the surface of the first layer coating. layer; the particle size of the hydroxyapatite powder is 38-53 microns, and the spraying power is 45kW;

[0024] (3) Crystallization treatment of the coating: the above-mentioned coating was raised from room temperature to 600° C. under the atmospheric environment, and kept for ...

Embodiment 3

[0026] (1) With medical pure titanium as the matrix, Al can be sprayed before spraying 2 O 3 For roughening treatment, the first layer of hydroxyapatite coating with a thickness of 35-40 microns is prepared by plasma spraying; the particle size of the hydroxyapatite powder is 45-90 microns, the spraying power is 30kW, and the plasma gas is mixed by volume The ratio of argon and hydrogen is 40:12, the spraying distance is 85-95 mm, and the powder feeding rate is 23-28 grams per minute;

[0027] (2) Repeat the above operation, during the operation, by using two spray guns to maintain the continuity of the spraying of the first layer and the second layer, a second layer of hydroxyapatite coating with a thickness of 25-30 microns is prepared on the surface of the first layer coating. layer; wherein the particle size of the hydroxyapatite powder is 20-38 microns, and the spraying power is 40kW;

[0028] (3) Crystallization treatment of coating: the above-mentioned coating was rai...

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Abstract

A surface nano-sized method of hydroxyapatite coat is disclosed. The preparation process includes: preparing of the first hydroxyapatite coat layer with thickness between 30 to 60 microns and the second hydroxyapatite coat layer with thickness between 20 to 40 microns by bi-technology process plasma spraying method, crystallizing treatment of coat layer. The coat layer for medical implant body material has excellent biological compatibility, comparative quick osteogenesis speed, firm interface combination and long term favorable stability.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and mainly relates to a surface nanometerization method for artificial dental implants, artificial joints and other bone internal fixation devices, in particular to a hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) coating surface nanometerization method. technical background [0002] Hydroxyapatite has excellent biosafety and bioactivity. As a bioactive coating for various implants in the bone, it can make the implant surface bioactive, shield the release of harmful ions, and improve the implant-osseointegration effect. speed etc. The current problems of phase composition and distribution are not conducive to its function and long-term stability after implantation. First, the hydroxyapatite coating is usually prepared by plasma spraying. During the spraying process, the original hydroxyapatite powder is subjected to a high temperature, resulting in decomposition and amorphization, resulting in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/42A61L27/12A61L27/00B05B5/00B82B3/00C01B25/37
Inventor 吕宇鹏王建华李木森朱瑞富
Owner SHANDONG UNIV
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