Unlock instant, AI-driven research and patent intelligence for your innovation.

Slow released doxazosin mesilate capsule and its preparation process

A technology for doxazosin mesylate and sustained-release capsules, which is applied in the field of doxazosin mesylate sustained-release capsules, can solve the problems of cumbersome preparation process, high and complicated production conditions, and achieve simple preparation process, Improve safety and effectiveness, good reproducibility

Inactive Publication Date: 2008-06-25
SHANDONG INST OF PHARMA IND
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] US 4,765,989 and Pfizer’s doxazosin mesylate controlled-release tablets are based on laser drilling and coating film controlled-release technology. The preparation process is cumbersome and complicated, and the production conditions are high and require special equipment.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Slow released doxazosin mesilate capsule and its preparation process
  • Slow released doxazosin mesilate capsule and its preparation process
  • Slow released doxazosin mesilate capsule and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] prescription:

[0033] Doxazosin Mesylate 4g

[0034] Blank pill core 200g

[0035] Hypromellose 2g

[0036] Eudragit RL100 4.0g

[0037] Triethyl citrate 0.66g

[0038] Talc 2.2g

[0039] Preparation:

[0040] The preparation method of doxazosin mesylate sustained-release pellets is as follows: take 2 g of hypromellose and slowly add it into 90 ml of 60% ethanol with a stirring device, and keep stirring until it dissolves into a clear solution. 4 g of doxazosin mesylate was added to 200 ml of anhydrous ethanol in the dark until dissolved. The above two liquids were combined as the coating liquid. Put 220g of blank pill cores in the coating pot, set the peristaltic pump speed to 20±5 rpm, air pressure 0.5~0.65Mpa, material bed temperature 45~50℃, spraying speed 5ml / min, use atomization The spray gun uniformly sprays the drug-containing liquid onto the pellet core, and operates intermittently. After spraying the coating liquid, it is first dried in a coating pan ...

Embodiment 2

[0042] prescription:

[0043] Doxazosin Mesylate 4g

[0044] Blank pill core 200g

[0045] Hypromellose 2g

[0046] Eudragit RS100 4.5g

[0047] Triethyl citrate 0.66g

[0048] Talc 2.2g

[0049] Preparation:

[0050] The preparation method of doxazosin mesylate sustained-release pellets is the same as that in Example 1.

Embodiment 3

[0052] prescription:

[0053] Doxazosin Mesylate 4g

[0054] Blank pill core 200g

[0055] Hypromellose 2g

[0056] Eudragit RL100 2.0g

[0057] Eudragit RS100 2.0g

[0058] Triethyl citrate 0.66g

[0059] Talc 2.2g

[0060] Preparation:

[0061] The preparation method of doxazosin mesylate sustained-release pellets is the same as that in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The present invention relates to slow released doxazosin mesilate preparation, and is especially slow released doxazosin mesilate capsule. The slow released doxazosin mesilate capsule has filler comprising doxazosin mesilate 1.0-4.0 wt%, blank pill core 70-95 wt%, adhesive 0.5-3.0 wt%, slow releasing material polyacrylic resin and / or ethyl cellulose 1.0-10.0 wt%, plasticizer 0.2-3.0 wt% and anti-sticking agent 2.0-10.0 wt%. The preparation process includes: preparing medicine-containing coating liquid, coating the medicine-containing layer, preparing slow releasing coating liquid, coating the slow releasing film and encapsulating. The slow released doxazosin mesilate preparation of the present invention can maintain effective and stable blood medicine concentration for 24 hr and less side effects.

Description

technical field [0001] The invention relates to an oral sustained-release preparation of doxazosin mesylate, in particular to a sustained-release capsule of doxazosin mesylate, which produces a regular and stable blood drug concentration after oral administration. Background technique [0002] Doxazosin mesylate is a selective alpha 1 Adrenoceptor blockers can dilate blood vessels, reduce vascular resistance, and lower blood pressure by blocking alpha receptors; by selectively blocking alpha adrenergic receptors in prostate smooth muscle matrix, capsule and bladder neck, improve the prognosis of patients with benign prostatic hyperplasia. symptom. Its structural formula is as follows: [0003] [0004] This product is mainly absorbed in the gastrointestinal tract, absorbed rapidly, and age and gender have no effect on absorption. Doxazosin mesylate is a product developed by Pfizer in the United Kingdom and obtained a compound patent in 1978. In 1988, doxazosin mesylat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/517A61K9/48A61K47/38A61K47/34A61P9/12A61P13/08A61K47/32
Inventor 逄书明孙玲孙杰
Owner SHANDONG INST OF PHARMA IND