Silybin flavonolignan and their production method and use

A technology of lipids and medicinal salts, applied in the field of organic chemistry and medicinal chemistry, can solve problems such as insufficient water solubility and bioavailability, and limited drug market
CN100528869CInactive Publication Date: 2009-08-19ZHEJIANG HISUN PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG HISUN PHARMA CO LTD
Publication Date
2009-08-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a silibinin flavonoid lignan compound with anti-free radical oxidation, liver protection, prevention and treatment of senile dementia and anti-aging activities and a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to the preparation method of the compound of formula (1) including its important intermediates and its pharmaceutical composition and medical application. The compound of the present invention has anti-oxidative damage protective effect on the primary cells of SD neonatal rats, and can be expected to be used as a medicine for preventing liver damage; Radicals, the activity of inhibiting the generation of lipid peroxides induced by free radicals, and the strong anti-free radical-induced damage to PC12 cells, so it can be expected to be a drug for treating various diseases caused by free radicals.
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Description

field of invention

[0001] The invention belongs to the field of organic chemistry and medicinal chemistry. Specifically, the invention relates to a preparation method and application of a novel silybin flavonoid lignan, which are obtained through a total synthesis method. The compounds of the present invention and their intermediates have protective effects against oxidative damage to primary liver cells of SD neonatal rats, and at the same concentration, their ability to resist oxidative damage to cells is much higher than that of the positive control quercetin, which can It is expected to be used as a drug for preventing liver damage; the present invention has tested the anti-oxidant free radical activity of this type of compound, and found that it has the functions of scavenging superoxide anion free radicals in vitro, scavenging diphenylpicrylphenylhydrazine free radicals, inhibiting free radicals Induced lipid peroxide generation activity, the above activity shows that th...

Claims

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