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Novel medicinal uses of icariin

A technology of icariin and medicine, applied in the field of pharmaceutical use of icariin

Active Publication Date: 2009-10-07
JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent publication CN1282584A discloses that icariin has the effect of preventing or treating sexual dysfunction and vasoconstriction, but about the effect of icariin in medicines that treat or prevent damage caused by bacterial toxin infection and enhance the efficacy of antibiotics No report; In view of this, the present inventor provides the application of icariin in the medicine for preparing treatment or prevention of damage caused by bacterial infection and enhancing the curative effect of antibiotics through a large number of experimental studies

Method used

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  • Novel medicinal uses of icariin
  • Novel medicinal uses of icariin
  • Novel medicinal uses of icariin

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0012] Preparation Example 1: Preparation of Icariin Injection

[0013] Weigh 1.00g of icariin, add 20ml of n-butanol and 30ml of propylene glycol to completely dissolve the saponin, add 0.15g of tetracaine hydrochloride and 0.02g of citric acid into 40ml of water for injection to dissolve completely, and mix the above aqueous solution Add to the drug solution and mix well; adjust the pH value to 5.5±1.0 with borax and boric acid; add 0.1% activated carbon for needles and keep warm at 85°C for 30 minutes, G 3 Filtrate through a vertically fused glass funnel, and filter through a 0.22um microporous membrane; the filtrate is divided into 7ml vials, each containing 2ml. Or lyophilized by a lyophilizer to make a lyophilized powder.

preparation example 2

[0014] Preparation Example 2: Preparation of Icariin Emulsion for Injection

[0015] Icariin

[0016] Dissolve icariin, soy lecithin and cholesterol in ethanol and add them to refined soybean oil, mix until clear, and remove the alcohol by rotary evaporation or nitrogen evaporation to obtain icariin 10mg / ml and 50mg / ml Cholesterol in soybean oil solution. Disperse poloxamer and glycerin into water for injection, slowly add icariin-containing phospholipid and cholesterol oil solution dropwise into the dispersion system under high-speed stirring conditions to prepare a coarse emulsion. The obtained coarse emulsion was further emulsified by means of a homogenizer under a pressure of 100 MPa. After the emulsification was completed, it was sterilized at 115°C for 30 minutes, and then packaged.

experiment example 1

[0017] Experimental example 1 Effect test of icariin on endotoxin lethality in mice

[0018] 1 material

[0019] Icariin injection: prepared according to Preparation Example 1.

[0020] Endotoxin: Department of Microbiology, Shanghai Second Military Medical University, batch number: 020412.

[0021] Second-class Kunming mice, weighing 19-21 g, were provided by the Experimental Animal Center of Shandong Provincial Natural Medicine Engineering Technology Research Center, certificate number: SYXK (Lu) 20030020.

[0022] Dexamethasone sodium phosphate injection: Tianjin Pharmaceutical Lianshui Co., Ltd., specification: 5mg, batch number: 030825.

[0023] 2 Methods and results

[0024] Mice were randomly divided into blank control group, dexamethasone group, icariin 400mg / kg group, 100mg / kg group, 50mg / kg group, 20mg / kg group, 10mg / kg group, 20 in each group, male and female Half. After intravenous injection of endotoxin 20mg / kg, the mice were administered intravenously, and t...

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PUM

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Abstract

The present invention provides the application of icariin in the preparation, treatment or prevention of damage caused by bacterial infection, and specifically relates to its application in the prevention or treatment of sepsis, endotoxemia and endotoxin shock caused by damage caused by bacterial infection . The invention also relates to its application in medicines for enhancing the curative effect of antibiotics.

Description

technical field [0001] The present invention relates to the application of icariin in the prevention or treatment of damage caused by bacterial infection and the application of drugs for enhancing the curative effect of antibiotics, in particular to the application of icariin in the prevention or treatment of sepsis, endotoxemia and endotoxin caused by bacterial infection. Application of drugs in shock and enhancing the efficacy of antibiotics. Background technique [0002] Bacterial toxins are divided into endotoxins and exotoxins. Endotoxins are lipopolysaccharides in the cell wall of Gram-negative bacteria. They are located in the outermost layer of the cell wall. The biological activity is very complex and has a wide range of effects on the body. It can activate a variety of inflammatory cells to release inflammation. It can cause severe and complex pathological changes in organs, and can cause shock, disseminated vascular coagulation (DIC), adult respiratory distress sy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/00A61K9/08A61K9/10A61K9/16A61K9/19A61K9/20A61K9/48A61P31/04
Inventor 田京伟孙盛茂蒋王林徐本明
Owner JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
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