Cartilage tissue engineering rack and its application

Abstract

The invention provides a novel double-layer cartilage tissue engineering scaffold, which is composed of a dense layer and a loose layer, and the dense layer and the loose layer are connected. Blocking effect but nutrients can come in and out freely. It can be better used in the repair of cartilage in the human body and the construction of cartilage tissue in vitro. This new type of scaffold can also be easily combined with various other biomaterials to form a composite scaffold, combining the advantages of various materials so as to be better applied to cartilage tissue engineering. During the specific production, the collagen obtained by the acid extraction method is made into solutions of different concentrations, and the collagen sponge is obtained after being dried by a freeze-drying machine. Get double brackets. The pore size of the scaffold is related to the concentration, and we can control the pore size of the scaffold with different concentrations.

Description

(1) Technical field [0001] The invention relates to a double-layer collagen support for cartilage tissue engineering, in particular to a support for cartilage repair in human body and construction of cartilage tissue engineering in vitro. (2) Background technology [0002] With the improvement of people's health requirements, more and more people advocate sports, and injuries to cartilage, bones, tendons, etc. are more common and more and more. Human articular cartilage is subjected to mechanical forces caused by various activities every day, and the muscle function gradually declines after middle age, which can easily lead to joint damage and cartilage destruction, while the cartilage's self-repair ability is weak, and continuous development will lead to cartilage degeneration. Osteochondritis thus occurs. In China, the prevalence of osteoarthritis is 50% among people over 50 years old, and 80% among people over 75 years old, and 53% of severe cases will lead to loss of jo...

AI Technical Summary

Problems solved by technology

But these treatments have their inherent drawbacks

Such as the adverse reaction of degradation products to the body, the rejection of the body caused by non-degradable materials and poor long-term effects, etc.

[0003] Most of the current applications are polymer materials or collagen sponges and other scaffolds to transfer chondrocytes to repair cartilage defects, but medical polymer materials are expensive and their degradation products are destructive to tissues, and there are many cartilage defects repaired by single-layer collagen sponges. The starting point of the present invention is to find a scaffold with good biological performance, which can provide enough intercommunicated cell tissue accommodation space, and has a blocking effect at the same time.

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