Polypeptide protein class-medicament under-tongue instant nanometer emulsion and 3D printing preparing method thereof

Abstract

The invention relates to a sublingual instant nanometer medical membrane of a polypeptide protein drug and the related three-dimensional printing preparation method. The medical membrane is formed by multiple layers of powder through bounding. The top and bottom layers of the membrane are made from binding liquid which contains permeation enhancer through bonding. The central zones of the middle layers are made from binding agents of a micro-emulsion containing medical polypeptide protein and soybean phospholipid; the peripheral zones are made from binding liquid which is the same with that of the top and bottom layers through bonding. The preparation of the invention comprises the following steps: prepare the medical polypeptide protein micro-emulsion through nano-technique; print and position the micro-emulsion at the center of the membrane through three-dimensional printing technique and smear binding agents containing transmembrane permeation enhancer at the peripheral zones with another printing head to bond medical membrane. The medical membrane can be quickly dissolved at the sublingual to give off the micro-emulsion granules which contain medicines, and under the effects of the transmembrane permeation enhancer, the membrane can permeate the sublingual mucous membrane and enter the circulation system. The whole technique is simple in process, high in automation and good in reproducibility.

Description

technical field [0001] The invention belongs to the field of drug delivery systems for polypeptide protein drugs, in particular to a sublingual instant nano drug film for polypeptide protein drugs and a three-dimensional printing preparation method thereof. Background technique [0002] The three-dimensional printing (Three Dimensional Print, 3DP) forming technology first proposed by MIT Sachs et al. (US patent, NO.5204055, 1993) is based on the concept of "layer-by-layer printing, layer-by-layer superposition" to prepare a special shape. or objects with complex internal structures. This technology uses powder as the material, the processing process is very flexible, the forming speed is fast, the operating cost is low and the reliability is high. It is one of the most viable new technologies in the rapid prototyping industry. The key equipment of this technology - 3D printer is generally composed of computer terminal, powder processing system (including powder feeding, lay...

AI Technical Summary

Problems solved by technology

The drugs used in all kinds of relevant literatures are based on dyes as models, or use small molecule synthetic chemical drugs as research objects. At present, the applicant has not found that 3D printing technology is specially applied to polypeptide protein drug delivery systems. There are no research documents and patents, and there is no report on the preparation of oral drug delivery system for polypeptide and protein drugs by integrating the advantages of 3D printing technology and nanotechnology

Images