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Heterologous decalcification bone-slurry-slurry used for repairing bone defect, and its preparing method

A technology for demineralized bone and bone defect, applied in the direction of prosthesis, medical science, etc., can solve the problems of difficult to meet the requirements of gelatin strength, limited application of bone paste, etc., achieve good bone induction and bone conduction, convenient self-curing, biological good compatibility

Inactive Publication Date: 2007-07-25
天津市第一中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the excipient glycerin (glycerol, Glycetin) that it uses is a kind of colorless, clear syrupy liquid, has hygroscopicity, and aqueous solution shows neutral reaction, and all can miscible with water and ethanol arbitrarily, but glycerin It has nephrotoxicity, and the dosage of bone paste in human body should not exceed 2ml / kg, which limits the application of bone paste
In the preparation of bone paste, gelatin is also used as an excipient, but it is difficult to meet the requirements of gelatin strength

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] In a clean area, accurately weigh 4 g of allogeneic demineralized bone matrix DBM particles with a diameter of 420-710 microns at room temperature, and transfer them to a clean vessel. Add 0.4 g of freeze-dried collagen particles cross-linked by 0.08-0.2% aldehyde cross-linking agent (specify specific product). Make it fully mixed with DBM in a vessel. Packed in 10ml syringes, each with 1g of the mixture, sterilized under 25kGy gamma rays, ready for use. When using, add 0.5g of sterile physiological saline, and reconcile the two into a paste. After the powder is reconciled with water, it will be in the shape of toothpaste, which can be shaped at will, and stored in a -20C refrigerator for later use.

Embodiment 2

[0028] In a clean area, accurately weigh 4 g of allogeneic demineralized bone matrix DBM particles with a diameter of 420-710 microns at room temperature, and transfer them to a clean vessel. Add 4 g of freeze-dried collagen particles cross-linked by 0.08-0.2% EDC carbodiimide compound cross-linking agent. Make it fully mixed with DBM in a vessel. Packed in 10ml syringes, each with 1g of the mixture, sterilized under 25kGy gamma rays, ready for use. When using, add 5g of sterile physiological saline, and reconcile the two into a paste. After the powder is reconciled with water, it will be in the shape of toothpaste, which can be shaped at will, and stored in a -20C refrigerator for later use.

Embodiment 3

[0030] In a clean area, accurately weigh 4 g of allogeneic bone matrix DBM particles with a diameter of 420-710 microns at room temperature, and transfer them to a clean vessel. Add 4 g of freeze-dried collagen particles cross-linked by 0.08-0.2% aldehyde cross-linking agent. Make it fully mixed with DBM in this vessel. Packed in 10ml syringes, each with 1g of the mixture, sterilized under 25kGy gamma rays, ready for use. Accurately weigh 50 mg of BMP, dissolve in 50 ml of a mixture of calcium chloride and guanidine hydrochloride, and filter to sterilize. When in use, take 1ml of the BMP solution and add it to a syringe containing 1g of the mixture to blend the two into a paste. After mixing the powder with water, it will be in the shape of toothpaste, which can be shaped at will, and stored in a -20C refrigerator for later use.

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PUM

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Abstract

A decalcified foreign bone paste for repairing dysostosis with better bone inducing and transferring action is prepared from decalcified foreign bone matrix particles, freeze-dried bone collagen particles cross-linked by aldehyde or diimine carbonide, and aseptic physiologic saline or bone morphogenetic protein solution. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a bone repair material, in particular to an allogeneic decalcified bone paste for bone defect repair and a preparation method thereof. Background technique [0002] The repair of bone defects is a thorny problem that has plagued surgeons for a long time. The materials currently used clinically, such as autologous bone and allogeneic bone, have defects to varying degrees. Bone paste (demineralizedbone matrix putty) is a new type of bone graft material, which belongs to the DBM family of products. Like other DBM products, it also uses Osteotech's patented bone fiber technology, which has good osteoinductive and osteoconductive properties. It has a wide and unique application value. It can be filled in the bone defect according to the actual size or shape, and can be shaped and filled between the two broken ends of the fracture. It also mixes easily with autologous bone or bone marrow and maintains its integrity. [0003] The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44
Inventor 姜文学
Owner 天津市第一中心医院
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