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Method for preparing composite microspheres with surface functional group and controllable function

A technology of surface functional groups and composite microspheres, which is applied in the field of nanotechnology preparation, can solve the problem that the fluorescence intensity of fluorescent microspheres cannot be designed according to actual application needs, the intensity of fluorescent microspheres cannot be well controlled, and multiple responses cannot be obtained. Functional microspheres and other problems, to achieve the effect of low cost, wide application range, and simple and easy method

Inactive Publication Date: 2007-10-17
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

[0003] After searching the literature of the prior art, it was found that the Chinese patent application number: 00116548.8, the invention named "Fluorescence-labeled polymer microspheres and its preparation method" proposes that fluorescent microspheres can be prepared by adsorption or chemical bonding, but, The intensity of fluorescent microspheres obtained by this method cannot be well controlled, and the fluorescent substances used are mainly organic fluorescent dyes, the fluorescence effect obtained is not good, and the fluorescence of fluorescent microspheres cannot be designed according to the needs of practical applications. Strong and weak functional microspheres that cannot obtain multiple responses

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  • Method for preparing composite microspheres with surface functional group and controllable function
  • Method for preparing composite microspheres with surface functional group and controllable function

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Embodiment 1

[0021] Take sulfonated polystyrene microsphere aqueous solution, polyallylamine hydrochloride aqueous solution (containing 0.1M NaCl), polystyrene sodium sulfonate aqueous solution (containing 0.1M NaCl) with a concentration of 1.0mg / ml; take 1ml of the above Sulfonated polystyrene microsphere solution, add 5ml of the above-mentioned polyallylamine hydrochloride solution, precipitate and absorb for 10min, centrifuge, then wash the precipitate after centrifugation with pure water for 10 times, and disperse the precipitate in 1ml Form a solution in water, add 5ml of the above-mentioned sodium polystyrene sulfonate solution to the solution, centrifuge after adsorption for 10min, and then wash the precipitate after centrifugation with pure water for 3 times; then add 5ml of polyallylamine The hydrochloride solution is treated according to the above process, so that the surface of the microspheres is sequentially adsorbed with three layers of polyelectrolytes, that is, the outer str...

Embodiment 2

[0023]Prepare sulfonated polymethyl methacrylate microsphere aqueous solution, polydiallyldimethylammonium chloride aqueous solution (containing 0.5M NaCl), polystyrene sodium sulfonate solution (containing 0.5 M NaCl); Take 1ml of the above-mentioned sulfonated polymethyl methacrylate microsphere solution, add 0.5ml of the above-mentioned polydiallyldimethylammonium chloride solution, after precipitation and adsorption for 60min, centrifuge, and then use pure water The solution is cleaned 6 times, and the supernatant is discarded, and the microsphere solution of one deck polyelectrolyte (polydiallyldimethylammonium chloride) is obtained on the surface; then add the above-mentioned sodium polystyrene sulfonate solution of 0.5ml, Centrifuge after 60 minutes of adsorption, wash 6 times, and disperse it in 1ml of water to form two layers of polyelectrolyte (microsphere outer layer structure: polydiallyldimethylammonium chloride / polyphenylene Sodium ethylene sulfonate) microsphere...

Embodiment 3

[0025] Take 2.5mg / ml aqueous solution of sulfonated polymethyl methacrylate microspheres, polyallylamine hydrochloride aqueous solution (2.0M NaCl), polystyrene sodium sulfonate solution (2.0M KCl); take 1ml Add 0.5 ml of the above-mentioned polyallylamine hydrochloride solution to the sulfonated polymethyl methacrylate microsphere solution, absorb for 60 minutes, centrifuge, wash the precipitate with pure water for 6 times, and discard the supernatant; Add 100ml of the above-mentioned sodium polystyrene sulfonate solution, centrifuge after adsorption for 60min, wash the precipitate 6 times, and then disperse the precipitate in 1ml of water to obtain two layers of polyelectrolyte (polyallylamine hydrochloric acid) sequentially adsorbed on the surface. Salt / sodium polystyrene sulfonate) sulfonated polymethyl methacrylate microsphere solution; get concentration is 2mmol / L, the surface has the CdTe quantum dot solution 6ml of mercaptoethylamine, add to above-mentioned surface sequ...

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Abstract

The invention relates to a preparation method of microsphere with surface functional group and controllable functionality, and to the field of nano-technology. The invention firstly uses the microsphere with the surface having ionic functional group as a starting shuttering to coat layer of layer the nano-particle with certain functionality or polyelectrolyte by the power of static electrification to obtain the composite microsphere with surface functional group and controllable functionality. The microsphere with surface functional group and controllable functionality prepared by the invention, of which the size is controllable, has single functionality or multiple functionality, can respond to the circumstance of magnetism, light and pH value, and the response intensity is controllable. Furthermore, the surface can have different functional groups. The invention can get an extensive use in the fields of biology medical carrier, bioanalysis and intelligent material, etc.

Description

technical field [0001] The invention relates to a preparation method in the field of nanotechnology, in particular to a preparation method of composite microspheres with surface functional groups and controllable functions. Background technique [0002] Layer-by-layer self-assembly technology is an assembly method developed by Decher et al. on the basis of self-assembly technology in the 1990s. It was originally mainly used to prepare thin films with ordered structures. Caruso et al. further expanded the original layer-by-layer self-assembly technology at the end of the 20th century, and proposed to use layer-by-layer self-assembly technology to modify the surface of nano- and micron-sized particles to meet functional requirements. These developments and improvements have enriched this alternative deposition-based assembly technology and provided a wider range of options for building functional devices. Fluorescent microsphere analysis technology is a technology that has de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/10B01J13/14C08F2/22C08F2/44
Inventor 孙康窦红静马武伟
Owner SHANGHAI JIAO TONG UNIV
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