Use of inactive BCG vaccine in preparation of use for treatment of allergic action diseases

A technology of inactivating BCG and allergies, which is applied in the application field of medicine, can solve the problems of limited treatment and reduce the treatment cost of patients, and achieve the effect of obvious curative effect, good treatment effect and long validity period

Inactive Publication Date: 2007-11-14
张锦铭
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Problems solved by technology

[0002] In the background technology, the notification number is CN1038390C public document, which records the technical scheme of "inactivated BCG composition", which is an aqueous preparation obtained after inactivation of BCG for the prevention of tuberculosis, and contains inactivated BCG per milliliter The amount is 0.75-2 mg; and it is introduced that inactivated BCG can stimulate monocyte-macrophages and T cells, enhance B cells, and also enhance the function of NK cells. It is clinically used to treat children with asthma, bronchial Inflammation, recurrent upper respiratory tract infection, and immune-related immune diseases have a significant curative effect, and no toxic side effects have been found; using inactivated BCG to treat diseases, patients do not need injections or medicines, and only inoculate inactivated BCG in scratches on the skin, relying on the body itself Regulate the immune function to achieve the effect of curing diseases, which not only reduces the cost of treatment for patients, but also does not have to bear the pain caused by injecti

Method used

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Embodiment

[0009] Embodiments Preparation method: under aseptic conditions in a sterile room, dissolve the BCG powder evenly with physiological saline, put 2-4 ml of each obtained BCG solution into ampoules, pack according to different concentration specifications, and each ml contains BCG Amount of 50-200 mg is packed into a sealed ampoule, and the BCG solution in the sealed ampoule is placed in a water bath, and the temperature of the water bath is adjusted to 60°C for 60 minutes to obtain an inactivated BCG water solution, and the inactivated BCG solution is placed in a freeze dryer , freeze-dried into powder, that is.

[0010] The inactivated bacillus Calmette-Guerin aqueous solution of the present invention is successfully inactivated only when it is confirmed that there is no growth of Mycobacterium tuberculosis after being cultured in a special culture medium for Mycobacterium tuberculosis for one month. Inactivated BCG freeze-dried powder is made from inactivated BCG water, which...

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Abstract

The present invention relates to an application of inactivated BCG vaccine in preparation of medicine for effectively curing allergic diseases. It is characterized by that it uses inoculation BCG and makes it undergo the processes of dissolving, ampule-filling, sealing, inactivating, every millilitre of said inactivated BCG vaccine contains 50-200mg of inactivated BCG, and freeze-drying so as to obtain the invented inactivated BCG vaccine powder. It can be made into various dosage forms, such as injection, oral preparation and spray, etc.

Description

technical field [0001] The invention relates to a new application of medicine, especially the application of inactivated Bacillus Calmette-Guerin in the preparation of medicine for treating allergic diseases. Background technique [0002] In the background technology, the notification number is CN1038390C public document, which records the technical scheme of "inactivated BCG composition", which is an aqueous preparation obtained after inactivation of BCG for the prevention of tuberculosis, and contains inactivated BCG per milliliter The amount is 0.75-2 mg; and it is introduced that inactivated BCG can stimulate monocyte-macrophages and T cells, enhance B cells, and also enhance the function of NK cells. It is clinically used to treat children with asthma, bronchial Inflammation, recurrent upper respiratory tract infection, and immune-related immune diseases have a significant curative effect, and no toxic side effects have been found; using inactivated BCG to treat disease...

Claims

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Application Information

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IPC IPC(8): A61K39/04A61K9/08A61P37/06A61P11/00A61P35/00A61P1/02
Inventor 张锦铭
Owner 张锦铭
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