Use of inactive BCG vaccine in preparation of use for treatment of allergic action diseases

Abstract

The present invention relates to an application of inactivated BCG vaccine in preparation of medicine for effectively curing allergic diseases. It is characterized by that it uses inoculation BCG and makes it undergo the processes of dissolving, ampule-filling, sealing, inactivating, every millilitre of said inactivated BCG vaccine contains 50-200mg of inactivated BCG, and freeze-drying so as to obtain the invented inactivated BCG vaccine powder. It can be made into various dosage forms, such as injection, oral preparation and spray, etc.

Description

technical field [0001] The invention relates to a new application of medicine, especially the application of inactivated Bacillus Calmette-Guerin in the preparation of medicine for treating allergic diseases. Background technique [0002] In the background technology, the notification number is CN1038390C public document, which records the technical scheme of "inactivated BCG composition", which is an aqueous preparation obtained after inactivation of BCG for the prevention of tuberculosis, and contains inactivated BCG per milliliter The amount is 0.75-2 mg; and it is introduced that inactivated BCG can stimulate monocyte-macrophages and T cells, enhance B cells, and also enhance the function of NK cells. It is clinically used to treat children with asthma, bronchial Inflammation, recurrent upper respiratory tract infection, and immune-related immune diseases have a significant curative effect, and no toxic side effects have been found; using inactivated BCG to treat disease...

AI Technical Summary

Problems solved by technology

[0002] In the background technology, the notification number is CN1038390C public document, which records the technical scheme of "inactivated BCG composition", which is an aqueous preparation obtained after inactivation of BCG for the prevention of tuberculosis, and contains inactivated BCG per milliliter The amount is 0.75-2 mg; and it is introduced that inactivated BCG can stimulate monocyte-macrophages and T cells, enhance B cells, and also enhance the function of NK cells. It is clinically used to treat children with asthma, bronchial Inflammation, recurrent upper respiratory tract infection, and immune-related immune diseases have a significant curative effect, and no toxic side effects have been found; using inactivated BCG to treat diseases, patients do not need injections or medicines, and only inoculate inactivated BCG in scratches on the skin, relying on the body itself Regulate the immune function to achieve the effect of curing diseases, which not only reduces the cost of treatment for patients, but also does not have to bear the pain caused by injections and drug side effects, and realizes the "effective, safe, convenient and cheap" treatment policy; More patients adapt to this treatment method to treat diseases. The applicant has conducted long-term research on the clinical application of inactivated BCG. Due to different factors such as age, immune function status, type of disease and individual differences in patients, the treatment time Also because when adopting different dosages and different routes of administration, better therapeutic effect can be obtained, and what the open document CN1038390C records is only a small amount of "inactivated BCG composition" and its application. In clinical application, due to Using the method of scratch application on the skin, the drug dose that the human body can bear is very limited, which limits the application range of the inactivated BCG aqueous solution, and the inactivated BCG aqueous solution has a short service life and cannot be stored for a long time or carried. Inconvenient, so it is difficult to meet the treatment requirements of the majority of patients