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Adamantine rattan slow release-controlled agent and its production

A technology of controlled release preparation and diamond, which is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of inconvenient use, rough preparations, large dosage, etc., and achieves simple and convenient use and reduced dosing. frequency, the effect of reducing strong side effects

Inactive Publication Date: 2007-11-21
何祖新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are defects such as rough preparation, large dosage (syrup: 20ml / time, equivalent to 30g of crude drug), poor taste, and inconvenient use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: get main medicine King Kong vine 150mg (particle<5pm), hydroxypropyl methylcellulose 750mg, disodium hydrogen phosphate 350mg, lactose 105mg, ethyl cellulose 175mg, magnesium stearate 35fag, talcum powder 10mg, Firstly mix the vine with ethyl cellulose, hydroxypropyl methyl cellulose, lactose, talc and disodium hydrogen phosphate, then add ethanol and dichloromethane to granulate and dry, and then add magnesium stearate after granulation , mixed and pressed into tablets, each tablet contains 15mg of the main drug King Kongteng.

Embodiment 2

[0032] Embodiment 2: get rattan vine 60mg, stearic acid 15mg, 10% ethyl cellulose ethanol solution 22ml, 95% ethanol 10ml, make capsule core thing with rattan vine, make compound capsule material with stearic acid, ethyl cellulose , using compressed air to form capsules by spray freezing method, the capsule diameter is 6-100um. Then take the obtained Deliang microcapsules (containing the main drug 15.0mg), microcrystalline cellulose 6S and mix them evenly, and take another 10ml of 10% L-based cellulose ethanol solution and mix them, pass through a 18-mesh sieve to make granules, and store them below 30~C Dry at low temperature, add 10.0 mg of magnesium stearate, and press into tablets. Each tablet contains 30mg of the main drug King Kongteng.

Embodiment 3

[0033] Example 3: Take 60 mg of the main drug King Kongteng; 180 mg of hydroxypropyl methylcellulose, 50 mg of lactose, 20.0 mg of micronized silica gel, and 5.0 mg of magnesium stearate. Mix the main ingredient with HPMC and lactose, sieve, add micropowder silica gel and magnesium stearate to make granules, and pack into capsules. Each capsule of the obtained preparation contains 15 mg of vajra vine.

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PUM

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Abstract

The invention is concerned with a sustained and controlled release agent of Jingangteng, relating to quick release part and controlled release part, Jingangteng total saponins, total flavonoids in 1 to 10 weight shares, sustained and controlled release assistant stuff in 20 to 200 weight shares. It reduces the times of giving medicine and enhances the adaptability of user. It has better effect to maintain the even concentration of blood and medicine inside of body and keeps the stability and long residual action of the sustained and controlled release medicine with easy using. It avoids the large undulation to concentration of medicine in blood to the common agent and the 'peak and paddy ' phenomena, thus it reduces the side effect produced by the higher concentration of blood and medicine, and it overcomes the limitation that when the concentration is too lower than the cure concentration and ensures the cure. It clears away the heat-evil and expels superficial evils to detumescence and lump softening for curing adnexitis, inflammatory masses and gynecologic inflammatory diseases.

Description

technical field [0001] The invention relates to a medicine for treating rheumatoid arthritis and a preparation method thereof, in particular to a slow- and controlled-release agent for rheumatoid rattan and a preparation method thereof. Background technique [0002] King Kongteng is the rhizome of Smilaxchina L. in the family Liliaceae. Also known as Vajra Thorn, False Saccharomyces japonicus, it is widely distributed in the hilly areas south of the Yangtze River, and its rhizomes are used for medicine. Its rhizome mainly contains various chemical components such as saponins and flavonoids. The saponins found in the rhizome include: 26-O-βD-glucose-(25R)-furosta-5,20-diene-3β, 26 -diol-3-O-α-L-rhamnose-(1-2)-O-[α-L-rhamnose(1-4)]-β-D-glucoside; 26-O- β-D-glucose-22-O-methyl-(25R)-furost-5-ene-3β,22,26-triol-3-O-[α-L-rhamnose (1-4) ]-β-D-glucoside; Dioscin (25R) spirostan-5-ene-3β-ol-3-D-α-L-rhamnose-(1-2)-O-[α-L -rhamnose(1-4)]-β-D-glucoside; Dioscin 3-O-α-L-rhamnose(1-2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K9/16A61K36/896A61P19/02A61P29/00
Inventor 何祖新
Owner 何祖新
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