Application of mannose in the preparation of medicine for treating pulmonary inflammation disease

A technology of mannose and medicine is applied in the application field of mannose in the preparation of medicines for treating pulmonary inflammatory diseases, which can solve the problems of limited treatment means, adverse effects, adverse reactions and the like, and achieves low price, strong practicability, and ease of use. The effect of preparation

Inactive Publication Date: 2010-05-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the treatment methods for the above diseases are limited, mainly based on ventilation support therapy and early application of glucocorticoids on the basis of large doses of antibacterial drugs. Although glucocorticoids can inhibit the accumulation of inflammatory cells and the release of inflammatory mediators, they also It will bring various types of side effects and adverse reactions, such as inhibiting the body's immune response, adversely affecting the body's metabolic function, water-salt balance, etc., and these overlap with the patient's symptoms. Therefore, it is necessary to find effective drugs that inhibit the accumulation and release of inflammatory cells in the acute phase with lower side effects

Method used

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  • Application of mannose in the preparation of medicine for treating pulmonary inflammation disease
  • Application of mannose in the preparation of medicine for treating pulmonary inflammation disease
  • Application of mannose in the preparation of medicine for treating pulmonary inflammation disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Protective effect of mannose on acute lung injury in mice

[0035] Experimental Materials and Methods

[0036] 1. Experimental animals

[0037] Clean grade (Grade II) male ICR strain mice (weight 20-22 g) were provided by the Experimental Animal Center of Zhejiang University School of Medicine, certificate number: SYXK (Zhe) 20040052. All operations and experimental procedures abide by the Regulations on the Administration of Laboratory Animals. Animals had free access to food and water before the experiment.

[0038] 2. Main reagents and instruments

[0039] (1) Lipopolysaccharide (LPS, Esherichia coli O127:B8): American Sigma Company;

[0040] (2) Mannose (D-mannose): American Sigma Company;

[0041] (3) Dexamethasone Sodium Phosphate Injection (dexamethasone, DXM, batch number: 050502): Zhejiang Xianju Pharmaceutical Co., Ltd.;

[0042] (4) Chloral hydrate: domestic analytically pure product;

[0043] (5) Urethane: domestic analytical pure product; ...

Embodiment 2

[0107] Example 2 The protective effect of mannose on the rat model of acute respiratory distress syndrome

[0108] The medicine prepared from the mannose of the present invention is at the doses of 15 mg / kg, 45 mg / kg, 135 and 405 mg / kg, and is controlled by other monosaccharides such as glucose 135 mg / kg, galactose 135 mg / kg and fructose 135 mg / kg , intravenous administration, prevention and treatment of endotoxin lipopolysaccharide (LPS)-induced acute respiratory distress syndrome model in rats, the results show that: mannose can protect LPS-induced arterial oxygen partial pressure decrease, arterial carbon dioxide partial pressure increase, pulmonary vascular ventilation Increased permeability, pulmonary edema, accumulation of inflammatory cells in the lungs, increased cytokine TNF-α, increased levels of myeloperoxidase (MPO), and decreased levels of superoxide dismutase (SOD). But other monosaccharides such as glucose 135mg / kg, galactose 135mg / kg and fructose 135mg / kg have ...

Embodiment 3

[0167] The prevention and treatment of embodiment 3 mannose to severe acute respiratory syndrome (SARS)

[0168]In mid-November 2002, the first case of infectious atypical pneumonia of unknown etiology (referred to as SARS) was discovered in Guangdong Province of my country. The disease quickly spread in Hong Kong and many other countries and regions, and almost all people who had close contact with patients with the disease were infected, with the highest infection rate among healthcare workers. Therefore, it immediately attracted the attention of the people, governments and the World Health Organization all over the world, and researchers from various countries also quickly joined the research on SARS (Zhao Xirong, et al. Clinical and Pathological Research Progress of SARS. China Journal of Hospital Infection 2003, 11(3): 1092-94). In early March 2003, the World Health Organization (WHO) issued a warning to the world and named the disease Severe Acute Respiratory Syndrome (...

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Abstract

The invention provides the application of carubinose in preparing medicine that can treat lung acute inflammation diseases. The molecular formula of carubinose is C6H12O6, the structure is D-carubinose. Said medicine comprises medicine acceptable shaping agent or carrying agent. The produced dosage form mainly comprises liquid dosage form, granule, tablet, gas spraying form, drop or pill. The invention can reduce the lung tissue TNF-alpha level of mice ALT model induced by LPS, release neutral granulocyte wettability in lung tissue, inhibit capillary blood permeability, decrease protein exudation and lung water content, reduce MPO level in BALF supernatant and improve pathologic change for lung tissue inflammation. The invention discloses the functions of anti-inflammation, anti-oxidationand pneumochysis reduction of carubinose.

Description

technical field [0001] The invention belongs to medicinal uses, relates to a new medicinal use of mannose, and in particular relates to the application of mannose in preparing medicines or health-care products for treating acute inflammatory diseases of the lung. Background technique [0002] Mannose, the name comes from the biblical manna. As one of the aldohexose sugars, it is not only an isomer, but also has many inseparable relationships with the most well-known glucose. Mannose molecular formula C 6 H 12 O 6 , molecular weight 180.16, density 1.539. The structure is linear and cyclic. There are two configurations of D- and L-one, and the common one in nature is D-mannose. [0003] As a sugar, mannose is undoubtedly the primary use as a sweetener, an additive for food and beverages, followed by medicine, and has a good adjuvant therapeutic effect on patients with diabetes, obesity, constipation and high cholesterol. According to reports, the breeding industry has ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7004A61K9/08A61K9/10A61K9/12A61K9/16A61K9/20A61P11/00
Inventor 谢强敏邓杨梅徐旋里董新威
Owner ZHEJIANG UNIV
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