Method for measuring magnesium calcium vitamin C preparation content

Abstract

The invention provides a content-determining method for a Mg-Ca vitamin C preparation. A specimen containing magnesium oxide and calcium oxide totally 0.4mmol is taken, lapped, placed into a porcelain crucible; a small amount of water is added; the mixture is heated slowly and shaken from time to time, so that the mixture is completely wet; heating is continued till no smoke exists. The mixture is placed in a 500-600 centigrade hi-temperature resistance oven for burning 20-60 minutes, taken out, cooled, moistened by a small amount of water, some 10-40% chlorhydric acid is added; the mixture is boiled so as to become dissolved, then cooled to room temperature, filtered; the filter paper is washed by 10-40% chlorhydric acid for 2-3 times, then by water 1-2 times; the filtering solution and the washing fluid are mixed, diluted by water to desired quantity, now the specimen solution is obtained. Some specimen solution is fetched, diluted by a specified dilution way, the volume of the Disodium Edetate diluting solution consumed by the total magnesium oxide and calcium oxide is recorded; some solution of specimen to be tested is fetched, diluted by a specified dilution way, the volume of the Disodium Edetate diluting solution consumed for determining the content of calcium oxide is recorded; finally the volume of the Disodium Edetate diluting solution consumed by magnesium oxide is obtained by subtracting the volume of the Disodium Edetate diluting solution consumed for determining the content of calcium oxide from the volume of the Disodium Edetate diluting solution consumed by the total magnesium oxide and calcium oxide. The method is rapid, accurate and easy, is applicable for quantitative determining of any mixture containing Mg and Ca.

Description

technical field [0001] The invention relates to the technical field of food or medicine measurement, in particular to a content determination method of magnesium oxide and calcium oxide in a magnesium calcium vitamin C preparation. Background technique [0002] Endemic fluorosis is a biogeochemical disease that mainly invades bones and teeth and involves various tissues of the body. Bones and teeth are the main storage tissues for fluorine. One of the recognized indicators of whether fluorosis drugs are effective. In 1975, Rao, S, R and other scholars of Osmania Medical College in India reported that they used serpentine to treat skeletal fluorosis and achieved positive curative effect. In 1977, Shangguan Cunmin of Xi'an Medical College used domestic serpentine to produce flunine tablets for the treatment of skeletal fluorosis, and the curative effect was remarkable. Magnesium-calcium-vitamin-C tablets composed of serpentine, calcium carbonate and vitamin C, its quality st...

AI Technical Summary

Problems solved by technology

[0003] In the original national standard content determination method, due to the complicated pretreatment process of the test product, it is labor-intensive and time-consuming

The specific test product contains silicate, and after being calcined at 700-800°C, the porcelain crucible corrodes severely, forming a glass jelly-like substance, which makes it difficult to filter in the pre-treatment, and the use of high-concentration nitric acid can easily cause the filter paper to corrode and rupture during filtration, thereby Resulting in low recoveries and poor method reproducibility

In addition, with the titration method stipulated in the original standard, the titration end point jump is not obvious, which makes it difficult to judge the end point and make accurate quantitative determination.