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Method for preparing bone-like apatite/polyamide composite material

A technology of bone-like apatite and composite materials, applied in the field of preparation of nano-apatite composite materials, can solve the problems of long composite time, difficulty in stabilization, and inability of PA to dissolve completely.

Active Publication Date: 2008-02-20
SICHUAN GUONA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the solubility of PA in methanol is very small, the compounding time is very long, and PA sometimes cannot be completely dissolved, and even the HA content of the obtained composite material is quite different from that of the original ingredients, and the stability is poor.
At the same time, due to the large amount of CaCl in the reaction system 2 Participating in the whole composite process, it may exchange or further react with the phosphate ion in apatite, thereby increasing the Ca / P ratio, changing the original Ca / P ratio in apatite, and making the obtained composite material The Ca / P ratio fluctuates greatly and is difficult to stabilize

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 100 g of bone-like apatite slurry with a Ca / P molar ratio of 1.65 (water content 75 wt%) into 200 ml of benzyl alcohol solvent, stir and heat up to 100 ° C under nitrogen protection, and start dehydration, and the stirring speed is controlled at 100 rpm . After dehydration to 150°C, 25g of polyamide 66 was added. Continue to stir and heat up to 180°C under nitrogen protection, and compound for 2 hours. After the reaction was completed, about 40% of the solvent benzyl alcohol was recovered under reduced pressure. The obtained composite material slurry was washed 6 times with deionized water at 70°C, and kept warm for 30 minutes each time, then washed 3 times with absolute ethanol, and vacuum-dried at 120°C to obtain 49g of bone-like apatite / polyamide 66 composite material , the yield was 98%. The composite material is white powder, the Ca / P molar ratio is 1.65, and the Ca / P ratio has no change before and after composite. Take 3 parts of the product and burn them ...

Embodiment 2

[0020] Add 12.5 g of bone-like apatite slurry with a Ca / P molar ratio of 1.63 (water content 80 wt%) into 160 ml of benzyl alcohol solvent, stir and heat up to 100 ° C under nitrogen protection, and start dehydration, and the stirring speed is controlled at 100 rpm / min. After dehydration to 150°C, 247.5 g of polyamide 6 was added. Under the protection of nitrogen, continue to stir and raise the temperature to 180° C., and compound for 2 hours. After the reaction is completed, 40% to 50% of the solvent benzyl alcohol is recovered under reduced pressure. The obtained composite material slurry was washed 6 times with 70°C deionized water, each time for 30 minutes, and then washed 3 times with absolute ethanol, and vacuum-dried at 120°C to obtain a bone-like apatite / polyamide 66 composite material 49.5 g, the yield is 99%. The composite material is white powder, the Ca / P molar ratio is 1.63, and the Ca / P ratio has no change before and after composite. Take 3 parts of the prod...

Embodiment 3

[0022]Add 175 g of bone-like apatite slurry with a Ca / P molar ratio of 1.63 (water content 80 wt%) into 100 ml of benzyl alcohol solvent, stir and heat up to 100° C. under nitrogen protection as in Example 1, and start dehydration. Dehydrate to 150°C, add 15g of polyamide 612, continue to stir under nitrogen protection and raise the temperature to 180°C, compound for 2 hours. After the reaction was completed, no more than 40% of the solvent benzyl alcohol was recovered under reduced pressure. The obtained composite material slurry was washed 6 times with 70°C deionized water, each time for 30 minutes, and then washed 3 times with absolute ethanol, and vacuum-dried at 120°C to obtain a bone-like apatite / polyamide 66 composite material 49.6 g, the yield is 99.2%. The composite material is white powder, the Ca / P molar ratio is 1.63, and the Ca / P ratio has no change before and after composite. Take 3 parts of the product and burn them at 600°C. The apatite content in the composi...

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Abstract

The invention provides a preparing method of the bone-like apatite / polyamide composite material, which is characterized in that the mixture sizing agent of the bone-like apatite and water is mixed with the benzyl alcohol, which is heated and dehydrated under protection of the inert gas; after that, continuously in the conditions of the inert gas protection, the temperature of 160 DEG C to 180 DEG C and the stirring, the polyamide is added to completely dissolve the mixture and remove the benzyl alcohol; finally, the remains is completely washed by use of water and ethanol and dried in vacuum and under 120 DEG C. Without any additives, the preparing method of the present invention is simple and convenient and is good for ensuring that the calcium-phosphor proportion of the obtained bone-like apatite / polyamide composite material does not change; moreover, compared with the charge calculation, the apatite content of the composite material has good exactness, repeatability and stability, and the compositions have perfect uniformity and high purity, which contains no impurity, promising the yield over 98 percent.

Description

technical field [0001] The invention relates to a method for preparing a nano-apatite composite material which can be used as a substitute material for bone repair, in particular to a method for preparing a bone-like apatite / polyamide composite material without using any auxiliary agent. Background technique [0002] Hydroxyapatite (HA) ceramics have good bioactivity and biocompatibility, can form a strong bond with bone, and are widely used in human body repair materials, but due to their brittleness, they are mainly used as Non-load material use. In order to improve its toughness, composite materials obtained from polymer components and hydroxyapatite have been widely studied and applied. Such as polyethylene composites filled with hydroxyapatite, composites of polybutylene terephthalate and polyvinyl alcohol filled with hydroxyapatite, and other polymer composites filled with hydroxyapatite. Combining tough polymer components with high bioactivity hydroxyapatite compone...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/18
Inventor 严永刚吕国玉李鸿曹侠杨怀旭杨爱萍
Owner SICHUAN GUONA TECH
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