Method of producing nano magnetic chitosan composite particle for photodynamic medicament carrier

A nano-magnetic and composite particle technology, which is applied in the direction of bulk transportation, can solve the problems of immaturity in the field of drug carriers, and achieve the effects of good dispersion, small average particle size, and uniform particle size

Inactive Publication Date: 2008-02-27
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the research and development technology for the joint use of chitosan and photosensitizer is not mature in the field of drug carriers.

Method used

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  • Method of producing nano magnetic chitosan composite particle for photodynamic medicament carrier
  • Method of producing nano magnetic chitosan composite particle for photodynamic medicament carrier

Examples

Experimental program
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Embodiment 1

[0027] Weigh 2.16g (0.008mol) FeCl 3 ·6H 2 O and 1.11g (0.004mol) FeSO 4 ·7H 2 O was dissolved in 40ml of deionized water, and under the protection of nitrogen at room temperature, 20ml of ammonia water with a concentration of 1.5mol / l was added point by point to the above solution to obtain a black precipitate. The precipitate was washed five times with deionized water and ethanol at intervals by means of magnetic separation. By means of magnetic separation, transfer 0.25 g of negatively charged nanometer iron ferric oxide particles into 4 ml of ethanol solvent, add 0.02 g of photodynamic drug porphyrin dipropyl ether diol, and fully absorb for 30 min. The above ethanol solution, which contains Fe that fully absorbs the photodynamic drug 3 o 4 For the base core to be coated, add 0.2 g of chitosan to 40 ml of 2% acetic acid aqueous solution, ultrasonically disperse for 30 min and then stir for 1 h to end the reaction. The magnetic separation is used for sufficient washin...

Embodiment 2

[0029] Weigh 2.16g (0.008mol) FeCl 3 ·6H 2 O and 1.11g (0.004mol) FeSO 4 ·7H 2 O was dissolved in 40 mL of deionized water, and under the protection of nitrogen at room temperature, 20 mL of ammonia water with a concentration of 1.5 mol / l was added point by point to the above solution to obtain a black precipitate. The precipitate was washed five times with deionized water and ethanol at intervals by means of magnetic separation. By means of magnetic separation, 0.15 g of negatively charged nanometer iron ferric oxide particles on the surface were transferred into 2 ml of ethanol solvent, and 0.01 g of photodynamic drug porphyrin dipropyl ether diol was added for full adsorption for 30 min. The above ethanol solution, which contains Fe that fully absorbs the photodynamic drug 3 o 4 For the base core to be coated, add 0.2 g of chitosan to 40 ml of 2% acetic acid aqueous solution, ultrasonically disperse for 30 min and then stir for 1 h to end the reaction. The magnetic se...

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Abstract

The invention relates to a method for preparing a nanometer magnetic chitose composite granule of a medicinal vector, which comprises the following steps: (1) getting the black deposit Fe3O4 by adding over ammonia in the solution with Fe3+ and Fe2+; (2) dispersing the deposit in the alcohol; adding photodynamic machine; absorbing sufficiently; (3) adding chitose acetic acid aqueous solution; dispersing with hyperacoustic; separating and cleaning deposit with magnetic; getting the nanometer magnetic chitose composite granule of a medicinal vector. The method has the simple operation, the small device, the low energy, the uniform granule, the good dispensability and the small granule diameter, which can escape the capture of reticuloendothelial system (RES), has the good bioavailability, the good magnetic response and the apparent photodynamic effect, and is easy to extend.

Description

technical field [0001] The invention belongs to the field of preparation of nano-magnetic composite particles, in particular to a method for preparing photodynamic drug carrier nano-magnetic chitosan composite particles. Background technique [0002] In the field of nano-magnetic drug carriers, since the late 1970s, there have been magnetic albumin microspheres, magnetic fluids, magnetic liposomes and organic composite particles. Studies have shown that magnetic albumin microspheres: large particle size, weak magnetic induction, easy to cause blood vessel embolism. Ferrofluid: Due to no package, it is highly reactive and unstable. Magnetic liposome: large particle size, difficult to prepare, easy to be captured by the reticuloendothelial system (RES). However, biodegradable nanoparticles have been widely studied because of their high drug loading capacity and good sustained release effect (J. Photoch. Photob. B.: Bio., 2002, 66, 89-106). Chitosan is a natural, hydrophilic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36
Inventor 周兴平黄鹏陈志龙
Owner DONGHUA UNIV
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