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Codonopsis pilosula fermentation liquor and uses thereof

A technology of fermented liquid and Codonopsis pilosula, applied in the direction of application, medical preparations containing active ingredients, plant raw materials, etc., to reduce environmental hazards, improve the modernization level of traditional Chinese medicine, and enhance the effect of medicine

Active Publication Date: 2008-03-12
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned fermentation mainly uses Codonopsis pilosula as a fermentation additive to affect the properties of some bacteria, but there is no report on the fermentation of Codonopsis pilosula as the main component of the medium.
[0011] Therefore, it has not been found in the existing literature that large edible fungi are used as the starting strain of traditional Chinese medicine fermentation, and Chinese medicinal materials are used as the main material of the fermentation medium to utilize the abundant cellulase, hemicellulase, pectinase, starch Enzymes, etc., decompose lignocellulose, hemicellulose, lignin, pectin and other substances in Chinese medicinal materials, and fully release the active ingredients of Chinese medicinal materials in the fermentation aqueous solution, especially the research on using oyster mushroom as the starting point for fermentation Studies on the fermentation of strains and traditional Chinese medicinal materials with Codonopsis pilosula as the main material of fermentation medium

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of Codonopsis pilosula fermentation broth.

[0027] The fermentation strain used in the present invention is large edible fungus Pleurotus ostreatus. The fermentation liquid is prepared according to the following method: the composition of the fermentation medium is 5-15% Codonopsis pilosula, 0.1-0.5% KH 2 PO 4 0.1~0.3%MgSO 4 and distilled water. Codonopsis pilosula is crushed to 60-mesh powder, and 120-150 mL of culture medium is sub-packed in a 500-mL triangular flask. After autoclaving, the liquid fermentation strain is inoculated with an inoculation amount of 5-15%. Shake at 25-28°C and 130-180r / min. Bed shaking culture, culture time is 6 ~ 10d, to obtain Codonopsis pilosula fermentation liquid. The ginseng fermentation broth is centrifuged at 3500-5000r / min to obtain a supernatant, which can be directly used as food, health products and medicines, or used as raw materials for preparing food, health products and medicines.

Embodiment 2

[0028] Example 2: Anti-fatigue activity of Codonopsis pilosula fermentation supernatant.

[0029] Experimental animals: healthy male Kunming mice, weighing 20±2g.

[0030] Experimental drugs: bacteria-added fermentation broth group (7g / kg), uninoculated shake flask group (7g / kg), decoction group (14g / kg). The blank group was given 0.4mL of distilled water every day, and the other groups were given 0.4mL of the corresponding medicinal solution every day. Continuous gavage for 15 days.

[0031] ①. Effect of fermentation broth on weight-bearing swimming time of mice:

[0032] Animal experiments and their results:

[0033] 30 minutes after the last gavage, the base of the tail of the mouse was loaded with 7% lead skin of the body weight, and placed in a swimming box with a water temperature of 25°C and a water depth of 30 cm to swim, and the time from the start of swimming to the death of the mouse was recorded, that is, the weight-bearing swimming time. The results are shown ...

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PUM

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Abstract

The invention relates to the art of Chinese medicine processing and bio-fermentation, in particular to a fermentation method of Chinese codonopsis and an application of fermented product through the method. The invention makes the fermentation of Chinese codonopsis by taking large edible fungus as the starting fungus of Chinese medicine fermentation, Chinese codonopsis as the main material of fermentation culture medium and adding a small amount of necessary nutrients for fungus production and growth. Animal experiments show that the fermented codonopsis liquid has the effect of resisting fatigue and improving excitement. The application of the invention refers to the fermented codonopsis liquid obtained through the method can be applied in preparing anti-fatigue medicine as well as corresponding health products and food.

Description

Technical field: [0001] The invention relates to the field of traditional Chinese medicine processing and biological fermentation, in particular to a fermentation method of the traditional Chinese medicine Codonopsis pilosula, and the application of the fermentation product obtained by the method. Background technique: [0002] Codonopsis Codonopsis is the dry root of Codonopsis Codonopsis and various plants belonging to the same genus. Its nature and taste are sweet and flat, non-toxic, and have the effects of invigorating the middle and replenishing qi, promoting body fluid and quenching thirst. Indications for weakness of the spleen and stomach, insufficiency of middle-qi, deficiency of lung-qi, injury of body fluid due to fever, shortness of breath and thirst, blood deficiency and chlorosis, dizziness and palpitation. Common Codonopsis include Sichuan Codonopsis, tube flower Codonopsis, ball flower Codonopsis, gray hairy Codonopsis, Xinjiang Codonopsis, etc. [1] . Cod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/344A61K9/00C12N1/14A61P43/00A23L1/30C12R1/645A23L33/105
Inventor 李红玉敢小双
Owner LANZHOU UNIVERSITY
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