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Duyiwei soft capsule and preparation method thereof

A unique, soft capsule technology, applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of unqualified disintegration, sedimentation of active ingredients, leakage of content ingredients, etc., and achieve significant stability. Sexual and therapeutic benefits, effects that enhance beneficial effects

Active Publication Date: 2008-05-21
江苏万高药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention provides a soft capsule containing the unique extract as an active ingredient, which successfully solves the common problems of the current soft capsule preparations, such as disintegration prolongs over time, and can also Significantly enhance the beneficial effect of Duyiwei, and have significant stability and therapeutic advantages over current marketed products
[0010] The object of the present invention is to provide a kind of unique soft capsule pharmaceutical preparation, especially the soft capsule preparation containing unique unique taste, which overcomes the defects of existing unique oral preparations, and overcomes the unqualified disintegration and disintegration that often occur in soft capsules. Poor stability issues such as substance migration, active ingredient sedimentation, and content ingredient leakage occur in the capsule, and the beneficial effect of unique taste is enhanced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Example 1: Preparation of Duyiwei Extract

[0104] Take the unique medicinal materials, crush, add water and decoct 3 times for 1 hour each time, combine the decoction, filter, and concentrate the filtrate into a clear ointment with a relative density of 1.30, and dry it below 80°C to obtain the unique extract.

Embodiment 2

[0106] Unique flavor extract: 0.25g

[0107] Soybean oil: 0.045g

[0108] Liquid paraffin: 0.045g

[0109] Tween-80: 0.09g

[0110] Beeswax: 0.005g

[0111] Hydrogenated palm oil: 0.01g

[0112] Soy lecithin: 0.005g

[0113]

[0114] Make 1 capsule (0.45g)

[0115] Preparation Process

[0116] Take the prescription amount of Tween-80 and soybean phospholipid, stir well until the mixture is uniform, and use it as the standby solution 1.

[0117] Take the unique flavor extract in Example 1 and pulverize it into a fine powder that can be sieved through a 200-mesh sieve, and add it to the above-mentioned standby solution 1, fully disperse and stir evenly, and the dispersion time shall not be less than 20 minutes, as the standby solution 2.

[0118] Take the prescription amount of soybean oil and liquid paraffin, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, stir evenly, let cool to about 50 degrees; pour t...

Embodiment 3

[0120] Unique flavor extract: 0.25g

[0121] Corn oil: 0.15g

[0122] Liquid paraffin: 0.05g

[0123] Tween-80: 0.025g

[0124] Beeswax: 0.005g

[0125] Hydrogenated palm oil: 0.01g

[0126] Soybean Lecithin: 0.01g

[0127]

[0128] Make 1 capsule (0.5g)

[0129] Preparation Process

[0130] Take the prescription amount of Tween-80 and soybean phospholipid, stir well until the mixture is uniform, and use it as the standby solution 1.

[0131] Take the unique flavor extract in Example 1 and pulverize it into a fine powder that can be sieved through a 180-mesh sieve, and add it to the above-mentioned standby solution 1, fully dispersed and stirred, and the dispersion time shall not be less than 20 minutes, as the standby solution 2.

[0132] Take the prescribed amount of corn oil and liquid paraffin, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, stir evenly, let cool to about 45 degrees; pour the solution into ...

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PUM

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Abstract

The invention provides a novel soft capsule of Lamiophlomis rotate, which includes base material, liquid paraffin, suspending agent, wetting agent and surface active agent. The soft capsule is capable of overcoming the problem of disintegration delay of the prior preparation; meanwhile, the soft capsule is also able to remarkably enhance the benefit effect of lamiophlomis rotate preparation. Compared with the existing products in the market, the invention has the advantages of remarkable stability and curative effect.

Description

Technical field [0001] The invention relates to a medicine soft capsule preparation containing a unique flavor extract, which can remarkably enhance the beneficial effects of the preparation. Background technique [0002] Duyiwei's current marketed dosage forms are tablets, capsules, and granules, which can relieve pain and stop bleeding. It is prepared from the unique medicinal material after water extraction and adding appropriate amount of excipients. The shortcomings of the granule formulation are clear at a glance. Each oral dosage is large, it needs to be dissolved with boiling water before being taken, and the medicine itself is very bitter, this kind of administration method with large dosage, poor taste and inconvenience, and inconvenience to carry, etc. It is very easy to cause poor compliance of patients to use; and the granules are not easy to store, and it is easy to absorb moisture and stain bacteria and then mold. Years of production and clinical practice have prov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/48A61K47/44A61P7/04A61P29/00A61K47/06
Inventor 姚俊华
Owner 江苏万高药业股份有限公司