Medicine for treating antibacterial drugs associated enteritis and preparation method thereof
A correlation and enteritis technology, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as high recurrence rate, high price, and no drug composition found
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Embodiment 1
[0028] [Example 1] Preparation of the effective components of the medicine of the present invention
[0029] a) Weigh raw materials: 40 grams of Coptidis Rhizoma, 60 grams of Scutellaria, 60 grams of Codonopsis, 40 grams of fried Atractylodes macrocephala, 40 grams of Poria cocos, 40 grams of Alisma, 40 grams of licorice and 40 grams of woody fragrance, set aside;
[0030] b) Coptis rhizome was extracted three times with 5-7 times of 50%-80% ethanol, each time for 1-3 hours, and the ethanol was recovered to obtain dry extract 1;
[0031] c) Scutellaria baicalensis soaked in warm water, combined with Codonopsis pilosula, Poria cocos, Alisma, licorice and Atractylodes macrocephala (stir-fried) and decocted in water three times, combined the decoction, filtered, and the filtrate was concentrated to a relative density of 1.15-1.20 (50°C), and placed for 24 hour, vacuum drying to obtain dry extract 2;
[0032] d) Add 8 to 10 times of water to the coarse powder of woody incense, st...
experiment example 1
[0035] experiment material:
[0036] drug:
[0037] The drug efficacy component of the present invention prepared in Example 1: every milliliter contains 5.0 grams of crude drug, and is diluted to a corresponding concentration with an appropriate amount of distilled water before use; penicillin G potassium salt injection: 400,000 units; gentamicin sulfate injection : 40,000 units; demethyl vancomycin tablet: 0.5g / tablet; berberine hydrochloride tablet: 0.1g / tablet; aspirin tablet: 0.5g / tablet.
[0038] Strains:
[0039] Human embryonic lung diploid subcultured cells 2BS; 24 clinical isolates of Staphylococcus aureus; 23 strains of Clostridium difficile, including standard strains and clinical isolates; 9 hamster isolates.
[0040] animal:
[0041] Golden hamster: half male and half female, weighing 70-80 grams; Wistar rat: male, weighing 150-160 grams; Kunming mouse: female and male, weighing 18-20 grams.
[0042] instrument:
[0043] GasPak anaerobic tank; inverted micro...
Embodiment 2
[0081] [embodiment 2] capsule preparation of medicine of the present invention
[0082] a) Weigh raw materials: 30 grams of Coptidis Rhizome, 30 grams of Scutellaria Baicalensis, 30 grams of Codonopsis Radix, 10 grams of fried Atractylodes macrocephala, 30 grams of Poria cocos, 30 grams of Alisma, 10 grams of licorice and 10 grams of woody fragrance, set aside;
[0083] b) Coptidis rhizome, 5-7 times of 50%-80% ethanol extraction three times, each time for 1-3 hours, recovering ethanol to obtain dry extract 1;
[0084] c) After soaking Scutellaria baicalensis in warm water, combine it with Codonopsis pilosula, Stir-fried Atractylodes macrocephala, Poria cocos, Alisma, and licorice, add water and decoct three times, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10-1.30 (50°C), and place it for 24 hours. Concentrate the supernatant under reduced pressure to a clear extract with a relative density of 1.10-1.30 (80°C), and dry it under reduced ...
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