Method for preparing medical knee joint cruciate ligaments

Abstract

The invention relates to a preparation method of a medical knee joint cruciate ligament, the steps mainly include that: the silk with the high quality is firstly selected to calculate the number of the weaving silk according to the biomechanics of the ligament, the silk is evenly divided into three parts to be braided and woven in the long strip cable-shaped silk cruciate ligament, and the medical knee joint cruciate ligament can be prepared by degumming, drying, silk protein fiber-collagen compound shaping and other steps. The invention has the advantages of convenient production, low cost and so on, when in use, the transplantation operation is simple, convenient, safe and reliable, etc. As the silk protein fiber, after the removal of sericin, has good mechanical properties and biocompatibility, the invention can bear the protection functions of knee joint stabilization, load conduction and articular cartilage of the natural cruciate ligament at the early stage of the transplantation, at the same time, the invention can support the cell growth and blood vessel growth at the advanced stage of the transplantation and be gradually degraded and absorbed along with the growth of the self-tissue and the regeneration of the cruciate ligament, so the invention provides a new choosing path for the treatment of the patients with the seriously damaged and apraxia knee joint cruciate ligament.

Description

technical field [0001] The invention relates to a method for preparing a medical cruciate ligament, in particular to a method for preparing a medical degradable and absorbable cruciate ligament of the knee, and belongs to the field of prosthetic materials. Background technique [0002] The cruciate ligament is located in the knee joint, which acts as a tough connection, maintains joint stability and coordinates joint movement, and is the most important stabilizer. Ligaments are also the transmission medium and accumulation place of various nutrients, and also the mechanical barrier against external proteins, including antigens, viruses and bacteria. In daily life, the probability of ligament injury is quite high, and the consequence is immediate instability of the joint and long-term degeneration of other tissues after the injury. Especially in patients with osteoarthritis, ligament damage has been proved to be one of the important early causes. With the in-depth understan...

AI Technical Summary

Problems solved by technology

With the in-depth understanding of the structure and function of the cruciate ligament, the importance of the cruciate ligament has been recognized, but the self-repair ability of the ligament is poor, and the injured ligament must be replaced surgically to restore its function

The replacements for treating ligament injuries mainly include two categories: one is allografts, including autografts and allografts. Autografts are easy to obtain and do not need to be sterilized, but there are large autologous trauma, inflammation of the donor site, and transplantation However, there are insufficient sources of allogeneic cruciate ligament transplantation, immune rejection, and potential risk of disease transmission, etc., which also limit its clinical application.

The second type is the artificial ligament developed later, but its clinical application has problems such as material and bone surface wear and stress fatigue, so it has not achieved good results

Synthetic degradable materials generally have poor cell affinity. Compared with natural biomaterials, synthetic materials have weaker ability to induce cell adhesion, growth and differentiation on their surfaces.

Images