Acanthopanax senticosus effective fraction extract, preparation and application thereof

A technology of effective parts and extracts, which is applied in the field of traditional Chinese medicine, can solve the problems of high production cost, large production pollution, and low content of active ingredients, and achieve the effects of low cost, less environmental pollution, and easy operation

Inactive Publication Date: 2008-07-09
HARBIN RENHUANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of them use syringin as the quality control standard, and there are some injection varieties that only have a single effective fraction of total flavonoids, and the existing technology is mostly based on organic solvent extraction, which not only has high production costs, but also has relatively high pollution in industrialized production. Large, and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1

[0029] Take 30g of Acanthopanax senticosus extract (in accordance with the 2005 Chinese Pharmacopoeia), add 30ml of water to dissolve it, precipitate with 50% ethanol, stand still, filter, collect the filtrate, the precipitate is washed with 50% ethanol solution, the washing liquid is In the filtrate, the filtrate is concentrated to recover ethanol to obtain a crude extraction aqueous solution; after fully stirring, filter, adjust the pH to 2, and then adsorb on the macroporous adsorption resin D-101 (produced by Cangzhou Baoen Chemical Co., Ltd.) to adjust the pH of the water It is eluted at 3; then eluted with 20% methanol solution with a pH of 3, collect this part of the eluate fraction, and concentrate it into a paste to obtain an extract of the total glycosides and total flavonoids of the effective part, which is measured by an ultraviolet spectrophotometer The analysis showed that the total glycoside content was 61.52%, the total flavonoid content was 23.8...

Example Embodiment

[0030] Example 2

[0031] Take 30g of Acanthopanax senticosus extract (in accordance with the 2005 Chinese Pharmacopoeia), add 45ml of water to dissolve it, precipitate with 70% methanol, stand still, filter, collect the filtrate, wash the precipitate with 70% methanol solution, the washing liquid In the filtrate, the filtrate is concentrated to recover methanol to obtain a crude extraction aqueous solution. After fully stirring, filter, adjust the pH to 4, and absorb by the macroporous adsorption resin AB-8 (produced by Nankai University Chemical Plant) to prepare a 10% ethanol solution Adjust the pH to 9 and elute; then elute with a 40% ethanol solution with a pH of 6, collect this part of the eluate fraction and concentrate it into a paste to obtain an extract of the total glycosides and total flavonoids of the effective part. The analysis by UV spectrophotometer showed that the total glycoside content was 32.6%, the total flavonoid content was 34.1%, and the total glycoside to...

Example Embodiment

[0032] Example 3

[0033]Take 30g of Acanthopanax senticosus water extract (in accordance with the 2005 Chinese Pharmacopoeia), add 90ml of water to dissolve, precipitate with 90% acetone, stand still, filter, collect the filtrate, the precipitate is washed with 90% acetone solution, the washing liquid is In the filtrate, the filtrate is concentrated to recover acetone to obtain a crude extract aqueous solution. After full stirring, it is filtered to adjust the pH to 7, and it is adsorbed by the macroporous adsorption resin HPD-100 (produced by Cangzhou Baoen Chemical Co., Ltd.) to a concentration of 20. % Acetone solution and adjust the pH to 4 for elution; then eluted with 60% acetone solution with pH 9 to collect this part of the eluent fraction and concentrate it into a paste to obtain the total flavonoids of the effective part. Analyzed by UV spectrophotometer, the total glycoside content was 21.57%, the total flavonoid content was 60.5%, and the total glycoside total flavono...

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PUM

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Abstract

The present invention discloses an extract of acanthopanax effective part, a preparation method thereof and an application thereof. In the acanthopanax extract of the present invention, total glycoside takes 20 to 64wt percent of the gross extract; total flavone takes 20 to 65wt percent of the gross extract; total glycoside total flavone takes 50 to 90wt percent of the gross extract. The preparation method of the acanthopanax effective part of the present invention is simple and convenient and causes little environmental pollution; the extracting and separating carrier can be used repeatedly for a plurality of times; the present invention has low cost and is applied to mass industrialization production.

Description

technical field [0001] The present invention relates to an extract of the effective part of a single plant, in particular to the extract of the effective part of Acanthopanax and its preparation method. Diseases, improving human immunity, anti-tumor, anti-radiation, and reducing the damage of radiation or chemotherapy drugs to the body belong to the field of traditional Chinese medicine. Background technique [0002] Acanthopanax is the dry root and rhizome of Acanthopanax senticosus (Puper.er Maxim) Harms, a plant of Araliaceae. Acanthopanax is a typical medicinal plant in Northeast my country. It is pungent, slightly bitter, warm in nature and non-toxic. Mainly distributed in my country's Heilongjiang, Jilin, Liaoning, Hebei and other places. [0003] Acanthopanax is a plant medicine with high medicinal value and a wide range of applications. In recent years, Chinese medicine workers have discovered that Acanthopanax has the effects of nourishing qi and strengthening the...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P9/10A61P25/24A61P15/12A61P35/00A61P37/04A61P17/16
Inventor 崔玉海张颖李男刘欢欢
Owner HARBIN RENHUANG PHARMA
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