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Antibiotic sustained release system building method of medical titanium alloy implant surface

A construction method and implant technology, which is applied in the field of preparation of medical anti-infection metal implant materials, can solve problems such as coating peeling off, unresolved effective combination of coating and metal materials, unfavorable clinical use, etc., and achieve stable combination The effect of strength, improving physical adsorption and chemical bonding ability

Inactive Publication Date: 2008-07-23
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two main defects in the metal surface drug coating materials currently studied. One is that the effective combination between the coating and the metal material has not been solved, and the coating is prone to fall off due to physical and chemical factors, which is unfavorable for clinical use. It is difficult to achieve precise regulation of the sustained release of antibiotics

Method used

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  • Antibiotic sustained release system building method of medical titanium alloy implant surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1) Preparation of microporous layer morphology on the surface of medical titanium alloy implants:

[0016] First, mix titanium beads with a diameter of 0.2-0.3mm with the additive urea, in which titanium beads or titanium powder account for 40% of the mass of the mixture, and then apply the mixture on the surface of the prosthesis with a coating thickness of 0.5-1.0mm , and put it in a vacuum furnace for sintering at 1000°C for 3 hours to sinter the titanium beads together and sinter with the prosthesis at the same time; use high temperature to volatilize the additives naturally, and the temperature close to the melting point will sinter the beads to each other , while sintering it with the prosthesis. The sintering of titanium beads is generally double-layer or three-layer. After sintering, the size of the three rows of beads is 0.6-0.9mm, the pore size is 100-300μm, and the average porosity is 30-60%;

[0017] 2) Modification of surface chemical properties of medical...

Embodiment 2

[0022] 1) Preparation of microporous layer morphology on the surface of medical titanium alloy implants:

[0023] First, mix titanium powder with a diameter of 0.2-0.3mm and additive magnesium powder, in which titanium beads or titanium powder account for 60% of the mass of the mixture, and then coat the mixture on the surface of the prosthesis with a coating thickness of 0.5-1.0mm , and put it in a vacuum furnace for sintering at 1100°C for 2 hours to sinter the titanium beads together and sinter with the prosthesis at the same time;

[0024] 2) Modification of surface chemical properties of medical titanium alloy implants

[0025] After the medical titanium alloy implant obtained in step 1 is ultrasonically cleaned, it is immersed in a 30% hydrogen peroxide solution, and the temperature is controlled at 67 ° C. After keeping it for 20 hours, it is taken out and cleaned with acetone solution. The medical titanium alloy implant cleaned with acetone solution The alloy implant wa...

Embodiment 3

[0029] 1) Preparation of microporous layer morphology on the surface of medical titanium alloy implants:

[0030] Firstly, titanium beads with a diameter of 0.2-0.3mm are mixed with the additive methylcellulose, wherein titanium beads or titanium powder account for 30% of the mass of the mixture, and then the mixture is coated on the surface of the prosthesis with a coating thickness of 0.5 -1.0mm, and put it in a vacuum furnace for sintering at 1050°C for 2.5 hours to sinter the titanium beads together and sinter with the prosthesis at the same time;

[0031] 2) Modification of surface chemical properties of medical titanium alloy implants

[0032] After the medical titanium alloy implant obtained in step 1 is ultrasonically cleaned, it is immersed in a 30% hydrogen peroxide solution, the temperature is controlled at 73°C, kept for 16 hours, taken out, cleaned with acetone solution, and the medical titanium alloy implant cleaned with acetone solution The alloy implant was pl...

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Abstract

The invention relates to a construction method of medical titanium alloy implant surface antibiotics slow release system. At first, titanium beads or titanium is mixed with an additive, and then the mixture is coated on the surface of prosthesis and titanium beads are sintered together by sintering, and at the same time, the titanium beads are sintered with the prosthesis; after being washed by ultrasound, the matter is immerged into the hydrogen peroxide solution, and then after being washed by the acetone solution, the matter is put into the carbonyldiimidazole acetone solution, and then after being washed by acetone solution, the matter is put into the sodium bicarbonate solution with dissolved RGD, then is washed by PBS after being taken out. Drugs curing and preventing bone infection and gelatin are combined into drug-loaded microspheres, then the drug-loaded microspheres are combined with the micro-porous layer on the surface of the prosthesis by protein cross-linker, thus obtaining the medical titanium alloy implant surface antibiotics slow release system. The medical titanium alloy implant surface antibiotics slow release system of the invention improves the physical absorption on metal surface and the chemical bond binding capacity, and stable combination strength between the low release microspheres and the implant can be obtained along with the function of the protein cross-linker.

Description

technical field [0001] The invention relates to a method for preparing a medical anti-infection metal implant material, in particular to a method for constructing an antibiotic slow-release system on the surface of a medical titanium alloy implant. Background technique [0002] Infection is the most serious complication after metal materials are implanted in the human body. At present, there are many ways to prevent and control the occurrence of post-implantation infection, one of which is to make the metal implant material itself have anti-infection ability. In order to make metal implant materials have effective anti-infection ability, many scholars have carried out various explorations. Some people try to use the antibacterial effect of metal silver ions to prevent and control the occurrence of infection around metal implant materials. But Masse A [Masse A, Bruno A, Bosetti M, et al. Prevention of pin track infection in external fixation with silvercoated pins: clinical...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/28A61L27/06A61L27/54
Inventor 郭征高勃郝玉琳吴红
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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