Method for synthesizing meropenem intermediate

A synthesis method and technology of meropenem side chain, applied in the direction of organic chemistry, etc., can solve the problems of poor stability, high energy consumption, long working hours, etc., and achieve the effects of improved stability and yield, low yield and long working hours
CN101225069AInactive Publication Date: 2008-07-23TIANJIN JINGYE FINE CHEM
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN JINGYE FINE CHEM
Publication Date
2008-07-23
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides a synthesis method of a side chain H of a meropenem, which is characterized in that a new radical is introduced respectively for three functional groups of 4R hydroxy L hydroxyproline and a certain spatial configuration is kept. The synthesis method for the side chain H of a meropenem has the advantages of moderate process conditions, stable product quality, and high yield, which is applicable to the industrial production on a large scale.
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Description

(1) Technical field:

[0001] The present invention relates to a method for synthesizing a meropenem intermediate, in particular to a method for synthesizing side chain H of meropenem. (two) background technology:

[0002] Meropenem (meropenem) is the first 1-Ξ²-methylcarbacyanase antibiotic used clinically. It has good chemical stability and is resistant to Ξ²-lactamase and renal dehydropeptide-I enzyme (DHP-I). Enzyme) is stable, has a broad antibacterial spectrum, and has obvious inhibitory effects on Gram-positive and negative bacteria. It is currently one of the first-selected drugs for the treatment of severe and multi-drug-resistant bacterial infections. In today's industrial production, meropenem is synthesized from the mother core MAP and the side chain H. Although there are many routes to synthesize the side chain H, most of them have long working hours, high energy consumption, poor stability and low yield. Therefore, the production and synthesis of meropenem side ch...

Claims

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