The invention discloses a vacuum compression bag with an antibacterial function and a production process thereof, and relates to the field of packaging materials. The vacuum compression bag is formed by a high-temperature-resistant outer layer, a first antibacterial adhesive layer, an impact-resistant intermediate layer, a second antibacterial adhesive layer and a corrosion-resistant inner layer from outside to inside through hot pressing. The production process comprises the seven procedures of preparation of the high-temperature-resistant outer layer, preparation of the impact-resistant intermediate layer, preparation of the corrosion-resistant inner layer, preparation of an antibacterial adhesive, coating, hot-pressing and rewinding and hot melting. Compared with the prior art, the vacuum compression bag has excellent antibacterial property, corrosion resistance, impact resistance, breakdown resistance and high temperature resistance, and is suitable for vacuum storage of materials in a high-temperature corrosion environment, the impact strength reaches 36 MPa, the tensile strength reaches 52.4 MPa, the elongation at break reaches 106%, and the antibacterial rate to escherichia coli, staphylococcus aureus and candida albicans reaches 99.7%, 98.3% and 95.7% correspondingly.