Preparation method of liposome embedded quantum dots silicon dioxide microspheres and products thereof

A silicon dioxide and liposome technology, applied in the preparation of microspheres, preparations for in vivo tests, chemical instruments and methods, etc., can solve the problem of only a small amount of quantum dots can be embedded, and overcome the uneven particle size distribution , Improve the intensity of light signal, reduce the effect of toxicity
CN101362066BInactive Publication Date: 2010-12-22TONGJI UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
TONGJI UNIV
Publication Date
2010-12-22
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention relates to a method for preparing silicon-dioxide microspheres with liposome embedded with quantum dots. The method includes the following steps: lipid material is dissolved in an organic solvent for being prepared to be a lipid film by rotary evaporation; the lipid film is added with a water solvent of the quantum dots for being prepared to be the liposome taking lipid as the film and the quantum dots as the core and with a grain size less than or equal to 10 Mum by a thin film dispersing method; the lipsome is added with tetraethyl orthosilicate to form silicon dioxide on the surface of the lipsome so as to obtain the silicon-dioxide microsphere with the liposome embedded with the quantum dots. The method has the advantages that: the silicon-dioxide microsphere with the liposome embedded with the quantum dots can decrease the toxicity of the quantum dots, increase the light signal intensity of every luminous point, and obtain microspheres with large quantity and different fuorescence spectra characteristics so as to play a part in biological high-flux detection. The quantum-dot microsphere of micron size is applicable to the cure of tumour artery embolism; and the quantum-dot silicon-dioxide microspheres with different grain sizes evenly arranging from nanometer to micron can be obtained by the method.
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Description

field of invention

[0001] The preparation method of liposome-embedded silicon dioxide microspheres with quantum dots and the products thereof of the present invention relate to a method for preparing silicon dioxide microspheres and nanospheres embedded with a large amount of quantum dots, especially involving lipids Silica microspheres and nanospheres obtained by embedding quantum dot nanoparticles in liposomes, or embedding quantum dots and drugs at the same time, and then forming silica on the surface of liposomes, which can be used for biological Fluorescent labeling, or arterial embolization and imaging, belongs to the field of materials and biomedicine. Background technique

[0002] Quantum dots are semiconductor nanocrystals, whose scale is mainly distributed in the range of 1 to 10nm. Due to their superior fluorescence compared to conventional organic fluorescent dyes, such as relatively stable fluorescence, high quantum yield (that is, very bright fluorescence), qua...

Claims

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