Process for producing fluorescent composite microgel hypersensitive to temperature and pH

A microgel and sensitive technology, applied in the field of materials, can solve undisclosed problems and achieve the effect of not easy to agglomerate, simple operation and feasible process

Inactive Publication Date: 2009-04-08
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the research work involving the preparation of composite microgels with multiple r

Method used

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  • Process for producing fluorescent composite microgel hypersensitive to temperature and pH
  • Process for producing fluorescent composite microgel hypersensitive to temperature and pH
  • Process for producing fluorescent composite microgel hypersensitive to temperature and pH

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The process steps for preparing the fluorescent composite microgel sensitive to temperature and pH are as follows:

[0047] 1. Preparation of mixed surfactants

[0048] Weigh 0.047g Tween-80 and mix with 0.47g Span-80 to prepare mixed surfactant.

[0049] 2. Preparation of template oil phase

[0050] Add 0.517g of the mixed surfactant prepared in step 1 into a three-necked flask filled with 70mL of n-heptane, that is, the mass ratio of the mixed surfactant to n-heptane is 1:89 to prepare 46.675g of the template oil phase.

[0051] 3. Preparation of emulsion

[0052] Add 46.675g of the template oil phase prepared in step 2 into a three-necked flask, stir with a stirrer at a speed of 350-400 rpm, feed nitrogen at a flow rate of 2-3mL / min, and emulsify at 18-30°C for 60 minutes to prepare into an emulsion.

[0053] 4. Preparation of water phase

[0054]Weigh 0.069g of N,N'-methylenebisacrylamide, 0.96g of N-isopropylacrylamide, 0.11g of ammonium persulfate and 5.5mL o...

Embodiment 2

[0068] In the process step 6 of Example 1, weigh 0.1 g of N-isopropylacrylamide copolymerized methacrylic acid microgel and mix it with 0.55 mL of ammonia water with a mass concentration of 25% to 28%, that is, N-isopropylacrylamide The mass ratio of copolymethacrylic acid microgel to ammonia water with a mass concentration of 25% to 28% is 1:5, and it is left for 12 hours to make it fully swell, and 0.6 g of swollen N-isopropylacrylamide copolymethacrylate is prepared. Acrylic microgels. In process step 7, 1 mL of γ-aminopropyltriethoxysilane and 1.5 mL of n-heptane were mixed to prepare a mixed solution of γ-aminopropyltriethoxysilane and n-heptane. In process step 8, weigh 0.3g Span-80 and mix with 45mL n-heptane to make 30g of deposited oil phase, that is, the mass ratio of Span-80 to n-heptane is 1:100, and the 0.6g prepared in step 6 is swollen The N-isopropylacrylamide copolymerized methacrylic acid microgel was added to the 30g deposited oil phase emulsified for 40 mi...

Embodiment 3

[0070] In the process step 6 of Example 1, weigh 0.1 g of N-isopropylacrylamide copolymerized methacrylic acid microgel and mix it with 0.67 mL of ammonia water with a mass concentration of 25% to 28%, that is, N-isopropylacrylamide The mass ratio of copolymethacrylic acid microgel to ammonia water with a mass concentration of 25% to 28% is 1:6, and it is left for 12 hours to fully swell to prepare 0.7 g of swollen N-isopropylacrylamide copolymethacrylate Acrylic microgels. In the process step 7, 1 mL of γ-aminopropyltriethoxysilane was mixed with 4 mL of n-heptane to prepare a mixed solution of γ-aminopropyltriethoxysilane and n-heptane. In process step 8, 0.3g Span-80 was weighed and mixed with 55mL n-heptane to make 36.6g of sediment oil phase, that is, the mass ratio of Span-80 to n-heptane was 1:120, and the 0.7g prepared in step 6 The swollen N-isopropylacrylamide copolymerized methacrylic acid microgel was added to the 36.6g deposited oil phase emulsified for 40 minute...

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Abstract

The invention discloses a preparation method of fluorescent complex microgel which is sensitive to temperature and pH. The method comprises the technical steps of preparing a mixed surface active agent, preparing the oil phase of a template, preparing an emulsive liquid, preparing a water phase, preparing N-isopropyl acryl amide copolymerized methacrylic acid microgel, preparing turgid N-isopropyl acryl amide copolymerized methacrylic acid microgel, preparing a mixed liquid of Gamma-aminopropyl triethoxy silane and normal heptane, preparing a silicon dioxide polymer complex microballoon decorated by a surface deposited amino group, preparing a mixed liquid of fluorescein isothiocyanate and absolute ethyl alcohol as well as preparing the fluorescent complex microgel. In the invention, the fluorescein isothiocyanate with high quantum yield and good optical stability is adopted as fluorescent matter; the prepared fluorescent complex microgel is sensitive to temperature and pH; and the size of the prepared fluorescent complex microgel is in a micron range and is hard to be aggregated. The method has the advantages of reasonable design, practical technique and easy operation; moreover, reactions are carried out under normal temperature and the like; the method can be applied to the fields of controlled release of medicament, biological probe, chemical separation, and the like.

Description

technical field [0001] The invention belongs to the technical field of materials, and specifically relates to colloid chemistry, for example: preparation of colloid materials or solutions thereof not included in other classes; manufacture of microcapsules or microspheres. Background technique [0002] The physical-chemical properties and colloidal properties of environment-sensitive microgels will show corresponding stimuli responsiveness with changes in external environmental conditions (such as temperature, pH, light, ionic strength, electric field or magnetic field, etc.). called smart microgels. Due to the unique response properties of smart microgels to the external environment, more and more scientists have paid attention to them. series of research results. Among them, the research on temperature-sensitive microgel based on poly-N-isopropylacrylamide (PNIPAM) is particularly eye-catching. Its critical phase transition temperature is around 32°C. When the temperature...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/56C08L33/24C08K3/36C08K3/30
Inventor 张颖胡炜房喻
Owner SHAANXI NORMAL UNIV
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