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Technique for preparing compound amoxicillin oil suspension injection

A technology for amoxicillin oil and suspension injection, which is applied in the field of preparation technology of compound amoxicillin oil suspension injection, can solve the problems of high cost, limited application scope and the like, and achieves stable product quality and simple preparation method. Effect

Inactive Publication Date: 2009-04-15
HENAN AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the oil-suspension long-acting injections used in domestic veterinary medicine need to be imported, and the cost is high (the wholesale price of 100ml of 10% is as high as 120 yuan), which limits the scope of its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation process of the present invention is as follows:

[0030] (1) Put 95mL of neutral soybean oil in a pressure cooker or autoclave and heat it to 115.5°C. After sterilizing for 30 minutes, take out 20mL and let it cool to 60°C, add 1.8g of aluminum stearate to it, Formulated into 6.5% gel, heated to 110°C, kept for 30 minutes, then diluted with filtered and sterilized soybean oil to form 1.8% oil gel, filtered, and set aside;

[0031] (2) Take either 3.45 grams of potassium clavulanate or 7 grams of sulbactam sodium and 14 grams of amoxicillin according to the formula, and mix it with 20 mL of oil gel, then grind it, and add lecithin 0.05 grams while grinding. gram until it is well ground; after that, transfer any of the ground amoxicillin and potassium clavulanate or sulbactam sodium into a graduated cylinder, and add 30mL of oil gel. When the temperature of the oil gel is not lower than 70°C, Add 0.9mL of benzyl alcohol, 0.15g of Span-80:0.15g, and 0.15g ...

Embodiment 2

[0034] The preparation process of the present invention is as follows:

[0035] (1) Put 100mL of neutral soybean oil in a pressure cooker or autoclave and heat it to 120°C. After sterilizing for 45 minutes, take out 25mL and let it cool to 65°C. Add 2 grams of aluminum stearate to it. Prepare 8% gel, heat to 115°C, keep for 45 minutes, then dilute with filtered and sterilized soybean oil to form 2% oil gel, filter, and set aside;

[0036] (2) Take either 3.75 grams of potassium clavulanate or 7.5 grams of sulbactam sodium and 15 grams of amoxicillin according to the formula, and mix it with 20 mL of oil gel, then grind it, and add lecithin 0.06 gram until it is well ground; after that, transfer any one of the ground amoxicillin and clavulanate potassium or sulbactam sodium into a graduated cylinder, and add 35mL of gelatin. When the temperature of the gelatin is not lower than 75°C, Add 1 mL of benzyl alcohol, 0.17 g of Span-80, and 0.2 g of vitamin E into the measuring cylin...

Embodiment 3

[0038] The preparation process of the present invention is as follows:

[0039] (1) Put 105mL of neutral soybean oil in a pressure cooker or autoclave and heat it to 126.5°C. After sterilizing for 1 hour, take out 30mL and let it cool to 80°C, add 2.2 grams of aluminum stearate to it, Prepare a 10% gel, heat it to 120°C, keep it for 1 hour, then dilute it with filtered and sterilized soybean oil to form a 2.2% oil gel, filter, and set aside;

[0040] (2) Take either 4.05 grams of potassium clavulanate or 8 grams of sulbactam sodium and 16 grams of amoxicillin according to the formula, and mix it with 30 mL of oil gel, then grind it, and add lecithin 0.07 grams while grinding. gram until it is well ground; after that, transfer any one of the ground amoxicillin and clavulanate potassium or sulbactam sodium into a measuring cylinder, and add 40mL of oil gel. When the temperature of the oil gel is not lower than 80°C, Add 1.1mL of benzyl alcohol, 0.2g of Span-80:0.2g, and 0.3g of...

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Abstract

The invention discloses a preparation process for compound recipe amoxicillin oil suspensoid injection. The preparation process comprises the following steps: (1) heating, sterilizing and cooling down neutual soybean oil, adding aluminum stearate into the soybean oil to prepare gel, heating the gel, diluting the gel through the filtrated and sterilized soybean oil, and filtrating the gel for standby; and (2) taking amoxicillin and clavulanic acid according to a recipe, mixing the amoxicillin and the clavulanic acid with the factice, grinding the mixture in a mortar, adding lecithin into the mixture while grinding till the mixture is ground evenly, adding the factice and the like into the mixture, adding benzyl alcohol, span and vitamin E into a graduated cylinder, and stirring the mixture, adding the factice and the like into the graduated cylinder, packaging and sealing the mixture and obtaining the compound recipe amoxicillin oil suspensoid injection. The compound recipe amoxicillin oil suspensoid injection has the advantages that the compound recipe amoxicillin oil suspensoid injection has a long-acting slow-releasing action, and antibacterial activity against bacteria capable of resisting single recipe amoxicillin, ampicillin, ceftiofur, and the like, that is, the compound recipe amoxicillin oil suspensoid injection can effectively treat bacterial infection capable of generating ESBLs. The preparation process is simple and convenient.

Description

technical field [0001] The invention relates to a medicine, in particular to a preparation process of compound amoxicillin oil suspension injection. Background technique [0002] Amoxicillin is a broad-spectrum semi-synthetic penicillin commonly used in veterinary clinics. It can be used to treat Escherichia coli, Salmonella, Pasteurella, Proteus and other digestive tract, respiratory tract and urinary tract infections. With its wide application, strains resistant to amoxicillin continue to emerge. The main mechanism of drug resistance is the production of β-lactamase, which hydrolyzes the β-lactamase ring of amoxicillin to make the latter lose its antibacterial activity. Clavulanic acid and sulbactam sodium are irreversible competitive β-lactamase inhibitors, which can inhibit the β-lactamase produced by bacteria, restore the sensitivity of bacteria to amoxicillin, and improve the antibacterial activity of amoxicillin . [0003] Amoxicillin-clavulanic acid preparations ha...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/00A61K31/43A61K31/424A61P31/04
Inventor 胡功政刘建华莫娟武博达
Owner HENAN AGRICULTURAL UNIVERSITY
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