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Lipid-metabolism-improving agent

A technology of lipid metabolism and improving agent, which is applied in the fields of diet, feed, and medicine, and can solve the problems of no baby obesity and lifestyle-related diseases, and achieve the prevention and improvement of myocardial infarction and cerebral infarction, high safety, and promotion of metabolism. Effect

Active Publication Date: 2009-04-15
MORINAGA MILK IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, infants who drink milk are not overly obese, and there are no reports of infants who are obese enough to develop lifestyle-related diseases

Method used

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  • Lipid-metabolism-improving agent
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  • Lipid-metabolism-improving agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] [Example 1] (production of αs-casein)

[0097] First, prepare with urea containing 4M and 6.5×10 -5 2.4 L of strong anion exchanger (manufactured by Pharmacia Corporation) equilibrated with 0.02M Tris hydrochloric acid buffer solution (pH 8.0) of M dithiothreitol. After the buffer was removed from the strong anion exchanger, 90 g of sodium caseinate (manufactured by Morinaga Dairy Co., Ltd.) dissolved in 3 L of buffer was added, and the ion exchanger was gently stirred for about 30 minutes, then the supernatant was separated with a glass filter. Strong anion exchangers with adsorbed caseins (α casein, kappa casein and β casein) are thus obtained.

[0098] Next, add sodium chloride to the above buffer solution to 0.2 M, add 1.5 L of this solution to the aforementioned strong anion exchanger, and slowly stir the ion exchanger for about 30 minutes, then separate the supernatant with a glass filter. Since this supernatant contains κ and β-casein, this operation was repeat...

Embodiment 2

[0100] [Example 2] (manufacture of sheet-like lipid metabolism improving agent)

[0101] Add 100 g of lactulose (LACTULOSE) powder (manufactured by Morinaga Dairy Co., Ltd.), 635 g of maltodextrin (manufactured by Matsutani Chemical Industry Co., Ltd.), and 85 g of skimmed milk powder (manufactured by Morinaga Milk Industry Co., Ltd.) to 150 g of αs-casein obtained by the method of Example 1. ), 1 g stevia sweetener (San-Ei Gen F.F.I., Inc.), 5 g yogurt flavor (San-Ei Gen F.F.I., Inc.), 24 g glycerin fatty acid ester preparation (RIKEN VITAMIN CO., LTD. ) respective powders, mixed evenly, using a tablet machine ( Iron and Steel Works Co., Ltd.), 0.5 g per tablet, at a tableting speed of 12 tablets / min, the aforementioned mixed powder was continuously compressed under a pressure of 9.8 KPa to produce 1,800 tablets (about 900 g) of αs-casein-containing Tablet (lipid metabolism improving agent). α s-casein per one tablet was about 15% by mass.

Embodiment 3

[0102] [Example 3] (Preparation of enteral nutritional food powder containing lipid metabolism improving agent)

[0103] In the tank, an aqueous phase was prepared in which 10 kg of whey protein hydrolyzate (manufactured by Morinaga Dairy Co., Ltd.), 36 kg of dextrin (manufactured by Showa Sangyo Co., Ltd.) and a small amount of water-soluble vitamins and minerals were dissolved in 200 kg of water. In addition, 3 kg of soybean salad oil (manufactured by Sun Oil Co., Ltd.), 8.5 kg of palm oil (manufactured by Sun Oil Co., Ltd.), 2.5 kg of safflower oil (manufactured by Sun Oil Co., Ltd.), 0.2 kg of lecithin (manufactured by Ajinomoto Co., Ltd.), 0.2 kg of monoglycerides of fatty acids (manufactured by Kao Corporation) and a small amount of fat-soluble vitamins were used to prepare an oil phase. Add the oil phase to the water phase in the tank, stir and mix, heat to 70°C, and homogenize under a pressure of 14.7Mpa with a homogenizer. Then, after sterilization at 90° C. for 10 m...

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Abstract

An agent for improving the lipid metabolism, a beverage / food, and an animal feedstuff, each comprising as-casein as an active ingredient; and an agent for preventing the increase in body weight, an agent for reducing the body fat, and an agent for reducing blood lipid level, each comprising the agent for improving the lipid metabolism.

Description

technical field [0001] The present invention relates to medicaments, food and beverages, and feeds that contain milk-derived casein, particularly αs-casein, as an active ingredient and have an effect of improving lipid metabolism. More specifically, the present invention relates to drugs, food and beverages and feeds that promote or improve the metabolism of fat accumulated in the body due to excessive intake of food, especially subcutaneous fat and visceral fat, and have the effect of normalizing the body fat percentage. Furthermore, it also relates to a medicine, a food and drink, and a feed that have an action of normalizing the concentration of blood lipids such as cholesterol and neutral lipids in the blood. [0002] This application claims priority based on Japanese Patent Application No. 2006-161076 for which it applied on June 9, 2006, The content is referred in this application. Background technique [0003] It is known that obesity is prone to be complicated by va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P3/06A23L1/30A61K35/20A61P3/04A23K10/28
CPCA23V2002/00A61K35/20A61K38/17A23L1/3056A23K1/1631A23K20/147A23L33/19A61P3/00A61P3/04A61P3/06A23V2200/332A23V2200/326A23V2250/54246
Inventor 素本友纪池田正幸
Owner MORINAGA MILK IND CO LTD
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