Preparation method of glycerol for injection

Abstract

The invention discloses a preparation method of glycerol for injection. The method is characterized by comprising the following steps: firstly, pre-treating the crude glycerol to remove impurities with the particle size larger than 0.45 micron in advance; allowing the pretreated solution to pass through an ultrafiltration membrane; finally, sterilizing the ultrafiltered ultrafiltrate by ultraviolet radiation to remove minute quantities of bacteria from the ultrafiltrate to obtain the refined glycerol. The pre-treating process sequentially comprises decolorization and impurity removal by active carbon, rough filtration, fine filtration and millipore filtration. The glycerol product prepared by the method can reach the injection standard.

Description

technical field [0001] The invention relates to a preparation method of glycerin for injection. Background technique [0002] Glycerin is a substance with a sweet taste that Swedish pharmacist Scheele accidentally discovered when olive oil reacted with aluminum oxide in 1779. In 1883, Betty Luo proved that the chemical structure of glycerin is a trihydric alcohol. Glycerin (chemically named 1,2,3-propanetriol) is a colorless, clear, viscous liquid; sweet and hygroscopic. [0003] Glycerin is widely used, and there are more than 2,000 kinds of products in the United States that require glycerin in production; the application fields of glycerin are generally divided into two categories: direct contact with skin (including imports) and non-direct contact with skin. The former includes food, hair gel, toothpaste, cosmetics, medicine, etc.; the latter includes papermaking, defense industry, leather, paint, etc. Glycerin is also a widely used pharmaceutical excipient, especially...

AI Technical Summary

Problems solved by technology

[0008] The disadvantages of the distillation method are: 1. The distillation method consumes a lot of energy and the recovery rate is low, and the loss is as high as 40%.

3. The formed glyceraldehyde has a strange smell and is difficult to eliminate

4. Pyrogen deactivation requires too high temperature, which is easy to cause side reactions to the product

[0012] Disadvantages of the ion exchange method: 1. The production cannot be carried out continuously, and the operation cycle takes a long time

2. Regeneration of resin and disposal of waste resin are too expensive

3. The wastewater discharged from production contains a large amount of salt substances and is severely corroded

4. Different impurities in the purified substance need to use different resins, which has poor adaptability

5. Cannot remove pyrogen and sterilize

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