Novel use of total flavone of effective component of Cotinus coggygria and preparation

A technology of effective parts and total flavonoids, which is applied in the field of human medicines, can solve the problems of lack of research on active ingredients of Cotinus cotinus and lack of development of drug effects, and achieve the effects of improving animal hypoxia resistance, avoiding toxic and side effects, and reducing whole blood viscosity

Inactive Publication Date: 2009-07-08
崔恩贤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, people's research on Cotinus Cotinus is still in its infancy, and neither the specific effective parts and

Method used

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  • Novel use of total flavone of effective component of Cotinus coggygria and preparation
  • Novel use of total flavone of effective component of Cotinus coggygria and preparation
  • Novel use of total flavone of effective component of Cotinus coggygria and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Add starch or dextrin to the total flavonoids isolated from Cotinus sumac to make granules according to the existing technology for treating coronary heart disease, angina pectoris and myocardial infarction.

Embodiment 2

[0015] Example 2: The total flavonoids of Example 1 were made into capsules as a medicine for preventing and treating cerebral thrombosis and thromboembolic diseases.

Embodiment 3

[0016] Example 3: The total flavonoids of Cotinus cotinus were further separated to obtain quercetin and fisetin, which were dissolved in a solvent to make injections respectively. The injections are used as emergency medicines for treating coronary heart disease, angina pectoris and myocardial infarction, as well as cerebral thrombosis and thrombus Emergency medicine for embolic disease.

[0017] In the preparation of injections, conventional pH regulators (hydrochloric acid, sodium bicarbonate), bacteriostats, osmotic pressure regulators, and antioxidants need to be added.

[0018] The relevant pharmacodynamic report of the preparation of the present invention proves that the sumac preparation prepared by the present invention has the effect of improving the animal body's resistance to hypoxia and the effect of dissolving thrombus, see the following appendix for details.

[0019] appendix:

[0020] The effective part, harvest season and effective part screening of the antic...

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Abstract

One of the tasks of the invention is to define an effective part for using cotinus coggygria, and provide pharmacodynamics usages of the effective part and various preparations. The new usage of the effective part of the cotinus coggygria is that the leaves, stems, branches and roots of the cotinus coggygria are collected to extract general flavone as a drug which can improve animal organism hypoxia tolerance or thrombolysis, etc. The invention has the advantages that the effective part of the cotinus coggygria is defined, and the effective components are separated for medical use, thus obviously improving the therapeutic effect. Experiments prove that the preparation of the invention can obviously improve animal hypoxia tolerance and the effect thereof is equal to a western medicine antianginal drug Propranolol, thus avoiding the toxic side effect of the western medicine and having the actions of improving blood circulation and reducing whole blood viscosity. Therefore, the preparation can be applicable for preventing and curing coronary heart disease, angina pectoris, miocardial infarction, as well as obstruction of Qi in chest, dizziness, brachypnea, palpitation, chest distress or thoracodynia caused by internal resistance of congestion. Meanwhile, the preparation of the invention also has the actions of anticoagulation in vitro and thrombus dissolving.

Description

technical field [0001] The invention relates to the technical field of medicines for human use, in particular to the new application and preparation of total flavonoids, which are effective parts of Cotinus cotinus. Background technique [0002] Cotinus coggygra Scop. is a plant of the genus Cotinus coggygra in the Anacardaceae family, a deciduous shrub or small tree, up to 8m in height, and its leaves turn red after frost in autumn, commonly known as Fragrant Hills red leaves. Although this plant has not yet entered the Chinese Pharmacopoeia as a medicinal material, many pharmacodynamic tests in recent years have shown that it has antibacterial effects, significant anti-hepatitis activity, and obvious anti-fatigue effects. Research. In Chinese patent application 200610042000.3, the inventor studied the efficacy of Cotinus cotinus in anticoagulant, antithrombotic, hypotensive effects and therapeutic drugs. [0003] However, people's research on Cotinus Cotinus is still in ...

Claims

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Application Information

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IPC IPC(8): A61K36/22A61P9/10A61K125/00A61K127/00A61K135/00
Inventor 崔恩贤龙丽辉李欣常永孝李天生张洁群
Owner 崔恩贤
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