Preparation of quinoxaline derivatives

Abstract

The invention discloses a preparation method of a quinoxaline derivative. The method is characterized by condensing an o-diamino compound with an o-dicarbonyl compound in a polar solvent in the presence of catalyst Amberlyst-15 or NKC-9 dry hydrogen catalyzed resin Styrene-DVB to prepare the quinoxaline derivative. The preparation method takes ordinary tap water instead of a toxic organic solventas the solvent for a condensation reaction to obtain the quinoxaline derivative with high yield and high content. The catalyst can be recovered and can be reused for at least three times in a condition of no loss of the catalytic activity, thus effectively reducing the production cost. The preparation method of the quinoxaline derivative has the advantages of simple process operation, no environment pollution, and is fit for large-scale industrialized production.

Description

technical field

[0001] The invention belongs to the technical field of organic synthesis and relates to a preparation method of quinoxaline derivatives. Background technique

[0002] Quinoxaline derivatives are a very important class of nitrogen heterocyclic compounds. They have a wide range of biological activities, mainly including: antiviral; antibacterial; anti-inflammatory; antimicrobial; anthelmintic; anticancer; kinase inhibitor. Quinoxaline derivatives also form the basis of many insecticides, fungicides, herbicides, receptor antagonists. Although there are few reports on quinoxaline in nature, the synthetic quinoxaline unit is an important component of some antibiotics, such as echinazin and actinomycin, which have the ability to inhibit the growth of Gram-positive bacteria. effect. In addition, quinoxaline compounds have also been used in dyes, efficient electroluminescent materials, organic semiconductors, and DNA fragmentation reagents. In summary, quinoxalin...

Images