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Guiling dispersible tablets and preparation method thereof

A technology of dispersible tablets and Guiling tablets, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of low bioavailability of human body, rough extraction process, backward preparation process, etc., shorten the disintegration time and dissolution time of active ingredients, and fast onset time , the effect of meeting medical needs

Active Publication Date: 2009-07-22
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problems are: the extraction process is rough and the dosage is large; the fat-soluble active ingredients in the prescription cannot be effectively captured in the traditional process, which affects the efficacy of the drug; the preparation process is backward, resulting in low bioavailability and long onset time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] After drying 833 grams of Poria cocos, 416 grams of Atractylodes macrocephala (stir-fried) and 250 grams of angelica at 60°C, mix them evenly, crush them through a 10-mesh sieve, put them into an extraction tank, soak them in 0.5 times the amount of ethanol for 0.5 hours, control the extraction temperature at 35°C, and Pressure 10Mpa, CO 2 The flow rate is 80kg / h, extract for 1 hour, collect the supercritical extract, concentrate under reduced pressure at 60°C to a yield of 0.5%, and set aside; add 6 times the water to decoct the dregs after the above supercritical extraction for 0.5 hour, after water extraction Obtain the water extract, filter it, concentrate the filtrate to a specific gravity of 1.2, vacuum-dry it to dryness at 60°C, crush it through a 60-mesh sieve to become a dry extract powder for water extraction, and set aside; add crospovidone to the above-mentioned supercritical extraction concentrate 72 grams of XL (the weight ratio of the added crospovidone X...

Embodiment 2

[0025] After drying 856 grams of Poria cocos, 428 grams of Atractylodes macrocephala (stir-fried) and 215 grams of angelica at 60°C, mix them evenly, crush them through a 10-mesh sieve, put them into an extraction tank, soak them in 1 times the amount of ethanol for 0.8 hours, and control the extraction temperature to 40°C. Pressure 20Mpa, CO 2 The flow rate is 120kg / h, extract for 4 hours, collect the supercritical extract, concentrate under reduced pressure at 60°C to a yield of 2.7%, and set aside; add 8 times the water to the dregs after the supercritical extraction and decoct for 2 hours. Obtain the water extract, filter it, concentrate the filtrate to a specific gravity of 1.3, dry it in vacuum at 65°C until dry, crush it through a 60-mesh sieve to become a dry extract powder for water extraction, and set aside; add crospovidone to the above-mentioned supercritical extraction concentrate XL 24 grams (the weight ratio of the added crospovidone XL to the supercritical extr...

Embodiment 3

[0027] After drying 749 grams of Poria cocos, 500 grams of Atractylodes macrocephala (stir-fried) and 250 grams of angelica at 60°C, mix them evenly, crush them through a 10-mesh sieve, put them into an extraction tank, soak them in 2 times the amount of ethanol for 1 hour, control the extraction temperature to 45°C, and Pressure 27Mpa, CO 2 The flow rate is 160kg / h, extract for 5 hours, collect the supercritical extract, concentrate under reduced pressure at 60°C to a yield of 5%, and set aside; add 10 times the water to decoct the above-mentioned supercritically extracted dregs for 3 hours, and after water extraction Obtain the water extract, filter, concentrate the filtrate to a specific gravity of 1.4, vacuum-dry to dryness at 70°C, crush and pass through a 60-mesh sieve to become a dry extract powder for water extraction, and set aside; add crospovidone to the above-mentioned supercritical extraction concentrate 96 grams of XL (the weight ratio of the added crospovidone X...

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PUM

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Abstract

The invention discloses a guiling dispersing tablet, which is mainly prepared from a supercritical extract and / or a water extract of one, two or three raw material medicines selected from tuckahoe, rhizoma atractylodis macrocephalae and angelica, or effective parts of the supercritical extract and / or the water extract and pharmaceutical excipients, wherein the pharmaceutical excipients comprise a disintegrant which is crosslinked polyvinylpyrrolidone, sodium carboxymethyl starch, microcrystalline cellulose, low-substituted hydroxyproxyl cellulose or crosslinked sodium carboxymethyl cellulose or a composition thereof, a filling agent which is microcrystalline cellulose, superfine silica gel powder, lactose, dextrin or compressible starch or a composition thereof, and a lubricating agent which is superfine silica gel powder, talcum powder or magnesium stearate or a composition thereof. The invention also discloses a method for preparing the guiling dispersing tablet. The invention adopts novel pharmaceutical excipients and novel preparation technology to ensure that the disintegration time of medicine and the dissolution time of effective constituents are greatly shortened than a common guiling tablet, and the tablet has quicker taking effect, better therapeutic effect and convenient administration, and can better meet medical demand.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a Guiling dispersible tablet; in addition, the invention also relates to a preparation method of the Guiling dispersible tablet. Background technique [0002] Guiling Tablets (FBD) originated from Danggui Shaoyao Powder in "Synopsis of the Golden Chamber" by Zhang Zhongjing in the Han Dynasty, and it is a modern improved preparation of a thousand-year-old traditional Chinese medicine. It is now planned to be used for vascular dementia of Qi deficiency and blood stagnation type. Clinical trials have proved that it can effectively improve the patient's memory and physical fitness, and the curative effect is definite. Chinese Invention Patent Application Publication Specification CN1985866A (disclosure date: June 27, 2007) discloses the prescription of Guiling Tablets, which mainly consists of one, two or three kinds of raw materials selected from Poria cocos, Atractylod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/076A61K9/20A61K36/232A61K36/284A61K47/40A61K47/38A61K47/36A61K47/32A61P25/28
Inventor 虞伟阮克锋周迎新林志宏沈平孃朱丹妮严永清
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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