Continuous preparation method for nanometer dispersed vitamin A microcapsule

A nano-dispersion and vitamin technology, applied in microcapsules, medical preparations with non-active ingredients, capsule transportation, etc., can solve the problems of high emulsification temperature, long emulsification time, and deterioration of vitamin A, and achieve high bioavailability and product quality. The effect of wide application and small crystal size

Active Publication Date: 2009-08-26
ZHEJIANG NHU CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1) The emulsification process is carried out in batches, the emulsification time of a single batch is long, and the emulsification temperature is high, which will easily lead to the deterioration of vitamin A;
[0009] 2) High-speed shears and high-pressure homogenizers have high power and high energy consumption, and the local high temperature generated at the shearing part is difficult to control, and it is easy to cause vitamin A to deter

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Grind 100kg of vitamin A crystals together with 1898kg of ethanol and 2kg of ethoxyquinoline in a sand mill at a temperature of 20°C until the particle size of vitamin A crystals is 5 μm to obtain a vitamin A dispersion with a content of 5%.

[0024] Dissolve 1000kg gelatin in 9000kg water to make 10% gelatin aqueous solution, cool to 25°C for later use.

[0025] Pump the vitamin A dispersion above at a flow rate of 100kg / hour through the coil to the preheater to raise the temperature to 65°C and keep it warm for 5 minutes. After the vitamin A is completely dissolved, it is cooled to 25°C through the coil cooler, and then sent to In the high-gravity rotating packed bed crystallizer with a liquid distributor and a rotating speed of 1000 rpm, at the same time, the gelatin aqueous solution is pumped into the same high-gravity rotating packed bed crystallizer at a flow rate of 500kg / hour, so that vitamin A is precipitated in the form of nano-sized crystals, and a nano-dispe...

Embodiment 2

[0027] Grinding 100 kg of vitamin A crystals together with 898 kg of isopropanol and 2 kg of tocopherol in a sand mill at a temperature lower than 0° C. until the particle size of vitamin A crystals is 2 μm to obtain a vitamin A dispersion with a content of 10%.

[0028] Dissolve 450kg fish gelatin in 1800kg water to make 15% fish gelatin aqueous solution, cool to 15°C for later use.

[0029] Pump the vitamin A dispersion above at a flow rate of 100kg / hour through the coil to the preheater to raise the temperature to 60°C and keep it warm for 3 minutes. After the vitamin A is completely dissolved, it is cooled to 15°C through the coil cooler and then sent In the supergravity rotating packed bed crystallizer with a liquid distributor and a rotating speed of 1500 rpm, at the same time, the fish gelatin aqueous solution is sent into the same supergravity rotating packed bed crystallizer with a flow rate of 300kg / hour, so that Vitamin A is precipitated in the form of nano-sized cr...

Embodiment 3

[0031] Grind 100kg of vitamin A crystals together with 898kg of acetone, 1kg of BHT, and 1kg of BHA in a sand mill at a temperature lower than 10°C until the particle size of vitamin A crystals is 4 μm to obtain a vitamin A dispersion with a content of 10%.

[0032] Dissolve 1800kg of modified starch in 7200kg of water to prepare a 20% aqueous solution of modified starch, and cool to 20°C for subsequent use.

[0033] Use a pump to pump the above-mentioned vitamin A dispersion at a flow rate of 50kg / hour to the preheater to raise the temperature to 62°C and keep it warm for 4 minutes. After the vitamin A is completely dissolved, it is cooled to 20°C through the coil cooler, and then sent In the high-gravity rotating packed bed crystallizer with a liquid distributor and a rotating speed of 3000 rpm, at the same time, the modified starch aqueous solution is pumped into the same high-gravity rotating packed bed crystallizer with a flow rate of 450kg / hour. The vitamin A is precipit...

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PUM

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Abstract

The invention discloses a continuous preparation method for nanometer dispersed vitamin A microcapsule, comprising the following steps: the vitamin A crystal, the antioxidant and the solvent are ground until the particle size of the vitamin A is 2 to 5 mu m, the vitamin A dispersion liquid is prepared; the vitamin A dispersion liquid is heated by a preheater and dissolved and cooled, then the solution is sent into a crystallizer of the supergravity rotating packed bed with the liquid distributor, at the same time the water solution with protection colloid is sent into the above crystallizer of the supergravity rotating packed bed, the nanometer dispersed vitamin A dispersion liquid is obtained at the outlet, the dispersion liquid is in spray drying in the spray drying device with fluidization cooling device to obtain the nanometer dispersed vitamin A microcapsule. The invention has the advantage of continuous production, because the vitamin A crystal grain in the product is small, the product has wide application and high bioavailability.

Description

technical field [0001] The invention relates to a method for preparing continuous nano-dispersed vitamin A microcapsules, in particular to the preparation of continuous nano-dispersed vitamin A microcapsules using a high-gravity rotating packed bed. Background technique [0002] Vitamin A (VA) deficiency is one of the four major nutrient deficiency diseases in the world, and has always been concerned by researchers. The important role of VA on vision, growth and reproduction has been recognized. In recent years, some domestic studies have also found that VA deficiency or deficiency can affect other functions of the body, mainly including: immune function; hematopoietic and cell receptor functions; iron metabolism; VA deficiency can also cause epithelial keratosis of the respiratory tract and intestinal mucosa, increasing The body's susceptibility to respiratory tract and intestinal infectious diseases; affect burns, wounds and wound healing after surgery; damp and hot condi...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/07A61K47/42A61P3/02A61K47/36
Inventor 陈志荣陈建峰尹红赵宏祁勇石立芳仇丹初广文邵磊
Owner ZHEJIANG NHU CO LTD
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