Continuous preparation method for nanometer dispersed vitamin A microcapsule

Abstract

The invention discloses a continuous preparation method for nanometer dispersed vitamin A microcapsule, comprising the following steps: the vitamin A crystal, the antioxidant and the solvent are ground until the particle size of the vitamin A is 2 to 5 mu m, the vitamin A dispersion liquid is prepared; the vitamin A dispersion liquid is heated by a preheater and dissolved and cooled, then the solution is sent into a crystallizer of the supergravity rotating packed bed with the liquid distributor, at the same time the water solution with protection colloid is sent into the above crystallizer of the supergravity rotating packed bed, the nanometer dispersed vitamin A dispersion liquid is obtained at the outlet, the dispersion liquid is in spray drying in the spray drying device with fluidization cooling device to obtain the nanometer dispersed vitamin A microcapsule. The invention has the advantage of continuous production, because the vitamin A crystal grain in the product is small, the product has wide application and high bioavailability.

Description

technical field [0001] The invention relates to a method for preparing continuous nano-dispersed vitamin A microcapsules, in particular to the preparation of continuous nano-dispersed vitamin A microcapsules using a high-gravity rotating packed bed. Background technique [0002] Vitamin A (VA) deficiency is one of the four major nutrient deficiency diseases in the world, and has always been concerned by researchers. The important role of VA on vision, growth and reproduction has been recognized. In recent years, some domestic studies have also found that VA deficiency or deficiency can affect other functions of the body, mainly including: immune function; hematopoietic and cell receptor functions; iron metabolism; VA deficiency can also cause epithelial keratosis of the respiratory tract and intestinal mucosa, increasing The body's susceptibility to respiratory tract and intestinal infectious diseases; affect burns, wounds and wound healing after surgery; damp and hot condi...

AI Technical Summary

Problems solved by technology

[0008] 1) The emulsification process is carried out in batches, the emulsification time of a single batch is long, and the emulsification temperature is high, which will easily lead to the deterioration of vitamin A;

[0009] 2) High-speed shears and high-pressure homogenizers have high power and high energy consumption, and the local high temperature generated at the shearing part is difficult to control, and it is easy to cause vitamin A to deteriorate;

[0010] 3) Due to the batch operation, the emulsion is easy to separate during spray drying after emulsification, resulting in unstable product quality, and the aggregated vitamin A oil beads become large crystal particles in the product, thus affecting the bioavailability of the product ;

[0011] 4) The current emulsification method is difficult to disperse vitamin A in microcapsules in nanometer size, which affects the use in some products