Oxidation resisting dipeptide medicament intercalated houghite and preparation method thereof

A technology for oxidizing dipeptide and hydrotalcite, which is applied in the direction of pharmaceutical formulations, drug combinations, dipeptide components, etc., to achieve good thermal stability and shorten crystallization time

Inactive Publication Date: 2009-09-16
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Oxidation resisting dipeptide medicament intercalated houghite and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] A. Add 0.015mol of solid Mg(NO 3 ) 2 ·6H 2 O and 0.0075mol of solid Al(NO 3 ) 3 9H 2 O dissolved in 50mL to remove CO 2 Prepare a mixed salt solution of magnesium nitrate and aluminum nitrate in deionized water;

[0028] B. Dissolve 0.018mol carnosine and 0.0625mol NaOH in 50mL to remove CO 2 Prepare the mixed solution of carnosine and NaOH in deionized water;

[0029] C. Mix the nitrate solution prepared in step A under N 2 Slowly added dropwise to the mixed solution prepared in step B under protected conditions, stirred, and adjusted the pH range of the solution to 9 with 3mol / L NaOH;

[0030] D. Crystallizing the slurry obtained in step C at 60° C. for 24 hours;

[0031] E. The product is removed by CO 2 The deionized hot water was centrifuged and washed to neutrality, and dried at 70°C for 20 hours to obtain carnosine-intercalated hydrotalcite.

Embodiment 2

[0033] The slurry obtained in step C in Example 1 was transferred to a microwave rapid digestion tank, heated by microwave at 100° C. for 0.5 h, and the obtained product was used to remove CO 2 The deionized hot water was centrifuged and washed to neutral, and dried at 70°C for 24 hours to obtain carnosine-intercalated hydrotalcite.

Embodiment 3

[0035] Step A: take by weighing 15.384g Mg(NO 3 ) 2 ·6H 2 O and 11.2539g Al(NO 3 ) 3 9H 2 O dissolved in 100ml to remove CO 2 1. Prepare mixed salt solution with deionized water;

[0036] Step B: Dissolve another 7.2g NaOH in 100ml to remove CO 2 , deionized water;

[0037] Step C: Mix the nitrate solution prepared in step A under N 2 Slowly add dropwise to the lye prepared in step B under protected conditions, stir, adjust the pH range of the solution to 10 with 3mol / L NaOH, crystallize at 70°C for 40 hours, and remove CO 2 The deionized hot water is centrifugally washed to neutrality to obtain the nitrate hydrotalcite precursor;

[0038] Step D: dissolving carnosine in water, adding undried nitrate hydrotalcite precursor, the molar ratio of carnosine to aluminum ion is 1-3, and adjusting the pH to 8;

[0039] Step E: In 60 °C water bath and N 2 Ion exchange under protected conditions for 24 hours, the obtained product was used to remove CO 2 1. Centrifugal washing ...

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Abstract

The invention discloses an oxidation resisting dipeptide medicament intercalated houghite and a preparation method thereof, belonging to the technical field of dipeptide medicaments. The chemical formula thereof is: (Mg<2+>)1-x(Al<3+>)x(OH)a(L-Carnosine)b.mH2O. The preparation method thereof comprises the coprecipitation method and the ion exchange method; wherein the crystallization phase of the coprecipitation method and the reaction process of the ion exchange method both adopt the microwave-hydrothermal method. The invention has the advantages that: the microwave-hydrothermal method is adopted in the preparation process of the carnosine intercalated houghite, thus greatly shortening the crystallization period of the coprecipitation method and the reaction period of ion exchange method; the prepared dipeptide medicaments--- carnosine intercalated houghite composite material uses the space limited domain action of the houghite and the interaction between the subject and the object, thus having better thermal stability and certain slow release performance under normal conditions and being favorable for the storage thereof and the development of new dosing route.

Description

technical field [0001] The invention belongs to the technical field of dipeptide drugs, in particular to an antioxidant dipeptide drug-carnosine intercalated hydrotalcite and a preparation method thereof. The microwave hydrothermal method is adopted in the preparation process, which greatly shortens the crystallization time of the co-precipitation method and the reaction time of the ion exchange method. Background technique [0002] Carnosine is a natural water-soluble dipeptide substance present in the skeletal muscle of vertebrates, its structural composition is β-alanine-L-histidine, and its molecular weight is 226.24. The physiological properties of carnosine, such as buffering, anti-oxidation, activity of neuron transmission substrates, and the role of regulators of some enzymes, have been extensively studied. It is known that carnosine has been widely used in food additives and cosmetics industries. [0003] However, the use of dipeptides as drugs in clinical therapy...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K38/05A61P27/12A61P1/04
CPCA61K38/05A61P1/04A61P27/12
Inventor 卫敏陈秋华陆军段雪
Owner BEIJING UNIV OF CHEM TECH
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