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Anisodamine dry powder inhalation, preparation method and application thereof

A dry powder inhaler, anisodamine technology, applied in powder delivery, pharmaceutical formulations, drug delivery and other directions, can solve the problems of inconvenient use, slow onset of tablet effect, unsuitable for acute attacks, etc. Convenience, high drug bioavailability effect

Inactive Publication Date: 2011-05-04
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of injections and freeze-dried preparations needs to be used in the hospital, which is inconvenient to use, and the onset of tablets is relatively slow, so it is not suitable for acute attacks.
Other studies on anisodamine also include the research of anisodamine ointment [Kangjialan, for the treatment of frostbite and neonatal scleredema anisodamine ointment and preparation method, CN 1771951A], anisodamine eye drops for the treatment of myopia Patient [Zhu Zhengming et al., racemic anisodamine eye drops, CN 1899286A], anisodamine liposome [Fen Hwang et al, Biochimica et Biophysica Acta (BBA) 1986, 11: 713~716], anisodamine There are no relevant reports on dry powder inhalation research

Method used

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  • Anisodamine dry powder inhalation, preparation method and application thereof
  • Anisodamine dry powder inhalation, preparation method and application thereof
  • Anisodamine dry powder inhalation, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The anisodamine hydrobromide dry powder inhaler in this embodiment is a vesicle-type dry powder inhaler. Based on 1000 vesicles, the weight of the main drug anisodamine and the excipient components of the auxiliary materials is as follows:

[0032]

[0033] Taking the preparation of 1000 as an example, the preparation method of the above-mentioned anisodamine hydrobromide dry powder inhalation is as follows:

[0034] Anisodamine hydrobromide is pulverized with a jet mill, so that the average particle size of the drug particles is 1-10 μm, and it is used for later use; the hypromellose and lactose are pulverized or granulated, and the excipients with a particle size of 100-400 mesh are selected Granules, ready for use; mix anisodamine hydrobromide and excipient granules evenly by equal volume addition method, measure the content of the main drug, fill it into vesicles after passing the test, and obtain vesicular anisodamine hydrobromide dry powder for inhalation agen...

Embodiment 2

[0039] The anisodamine hydrobromide dry powder inhaler in this embodiment is a storage type dry powder inhaler. Based on 100 doses / bottle, the weight of main drug anisodamine and auxiliary material excipient is as follows:

[0040]

[0041] Taking the preparation of 100 doses / bottle as an example, the preparation method of the above-mentioned anisodamine hydrobromide dry powder inhaler is as follows:

[0042] Anisodamine hydrobromide is pulverized with a jet mill, so that the average particle size of the drug particles is 1-10 μm, and it is used for later use; mannitol is pulverized or granulated, and excipient particles with a particle size of 100-400 mesh are selected, and it is used for later use; Mix anisodamine hydrobromide and excipient granules uniformly by incremental method, measure the content of the main drug, and contain it in a multi-dose dry powder inhalation device in the form of a reservoir after passing the test to obtain the reservoir type anisodamine hydr...

Embodiment 3

[0044] The anisodamine hydrobromide dry powder inhaler in this embodiment is a vesicle-type dry powder inhaler. Based on 1000 vesicles, the weight of the main drug anisodamine and auxiliary excipients is as follows:

[0045]

[0046] Taking the preparation of 1000 as an example, the preparation method of the above-mentioned anisodamine hydrobromide dry powder inhalation is as follows:

[0047] Anisodamine hydrobromide is pulverized with a jet mill, so that the average particle size of the drug particles is 1-10 μm, and it is set aside; the lactose is pulverized or granulated, and the excipient particles with a particle size of 100-400 mesh are selected, and set aside; the same amount Mix anisodamine hydrobromide and excipient granules uniformly by incremental addition method, measure the content of the main drug, fill it into blisters after passing the test, and obtain the vesicular type anisodamine hydrobromide dry powder inhaler.

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Abstract

The invention discloses an anisodamine dry powder inhalation, the preparation method and the application thereof, belongs to the medicinal preparation field. The dry powder inhalation is composed by the components of: 10-70wt% of anisodamine and 30-90% of excipient. The preparation method comprises: milling the anisodamine into particles with size of 1-10[mu]m by a jet mill; pulverizing or palletizing the excipient into particles with average size of 10-200[mu]m; mixing the anisodamine and the excipient, collecting them into a gelatin or plastic capsule, or aluminum-plastic bubble, into a dry powder suction apparatus in storage mode to obtain the anisodamine dry powder inhalation of the invention. The anisodamine dry powder inhalation in the invention can be sued to treatment stomach and intestine angina, biliary tract spasm and smooth muscle spasmolysis; has a Fast-onset and high medicament biological availability, and is more convenient for injection.

Description

technical field [0001] The invention specifically relates to an anisodamine dry powder inhalation preparation and a preparation method and application thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Dry powder inhalers have attracted more and more attention in recent years because of their advantages such as direct action point, fast onset of action, no hepatic first-pass effect, no gastrointestinal enzymatic hydrolysis, and small drug dosage. In addition to being widely used in the diagnosis and treatment of respiratory diseases, dry powder inhalers are also playing an increasingly important role in the treatment of diseases in other fields. It has been reported that calcitonin is made into nasal dry powder inhalation to reduce blood calcium content in the body [Jin Fang et al., Chinese Journal of Pharmaceutical Industry 2007, 38(3): 200-203], or insulin is made into Dry powder inhalation is used for type 1 diabetes and some ty...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/72A61K31/46A61P1/06
Inventor 刘哲鹏杨世霆
Owner UNIV OF SHANGHAI FOR SCI & TECH