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Preparation technology of doxycycline hydrochloride for injection

A technology for doxycycline hydrochloride and injection, which is applied in the field of production technology of doxycycline hydrochloride for injection, and achieves the effects of hypoallergenicity, improved purity, and low adverse reactions

Active Publication Date: 2009-10-14
HAIKOU QILI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product has certain antibacterial activity against Neisseria gonorrhoeae, but the penicillin-resistant Neisseria gonorrhoeae is also resistant to doxycycline

Method used

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  • Preparation technology of doxycycline hydrochloride for injection
  • Preparation technology of doxycycline hydrochloride for injection
  • Preparation technology of doxycycline hydrochloride for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: A kind of production technology of doxycycline hydrochloride freeze-dried powder injection for injection

[0020] One, the preparation of injection grade doxycycline hydrochloride:

[0021] 1. Prescription:

[0022] Material name

Feeding ratio

Doxycycline Hydrochloride

1

Anhydrous Methanol

3

[0023] Absolute ethanol

6

[0024] 1.1 Production preparation

[0025] 1.1.1 Make prenatal preparations according to the requirements of sterile drug production;

[0026] 1.1.2 Use activated carbon to treat anhydrous methanol and anhydrous ethanol respectively according to the sterile requirements;

[0027] 1.1.3 Assemble the three-in-one filter according to the requirements, install the special dust-free filter cloth for this variety that has been sterilized by moist heat under the stainless steel filter plate, and tightly close all valves and bolts.

[0028] 1.2 Preparation

[0029] 1.2.1 Ad...

Embodiment 2

[0064] Embodiment 2: A kind of doxycycline hydrochloride freeze-dried powder injection production process

[0065] One, the preparation of injection grade doxycycline hydrochloride:

[0066] 1. Prescription:

[0067] Material name

Feeding ratio

Doxycycline Hydrochloride

1

Anhydrous Methanol

3

Absolute ethanol

6

[0068] 1.1 Production preparation

[0069] 1.1.1 Make prenatal preparations according to the requirements of sterile drug production;

[0070] 1.1.2 Use activated carbon to treat anhydrous methanol and anhydrous ethanol respectively according to the sterile requirements;

[0071] 1.1.3 Assemble the three-in-one filter according to the requirements, install the special dust-free filter cloth for this variety that has been sterilized by moist heat under the stainless steel filter plate, and tightly close all valves and bolts.

[0072] 1.2 Preparation

[0073] 1.2.1 Add 3 times the weight of doxycycline hyd...

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PUM

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Abstract

The invention discloses a preparation technology of doxycycline hydrochloride lyophilized powder for injection. The doxycycline hydrochloride prepared by the invention reduces the contents of toxicants including Beta-doxycycline and metacycline; the doxycycline hydrochloride for injection prepared from an injection-grade doxycycline hydrochloride is characterized by low acrimony, low irritability and low adverse reaction. The injection-grade doxycycline hydrochloride can be used for preparing medical preparation for intravenous injection, such as the doxycycline hydrochloride powder injection, lyophilized powder injection and injection liquid for in vivo injection and medication, and has the advantages of low acrimony, low irritability, low adverse reaction and the like.

Description

technical field [0001] The invention relates to a production process of doxycycline hydrochloride for injection. Background technique [0002] Doxycycline (doxycycline) is a broad-spectrum bacteriostatic agent, which has a bactericidal effect at high concentrations. Many rickettsia, mycoplasma, chlamydia, atypical mycobacteria, and spirochetes are also sensitive to this product. This product has a better effect on Gram-positive bacteria than Gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, and Yersinia are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but the penicillin-resistant Neisseria gonorrhoeae is also resistant to doxycycline. Due to the wide application of tetracyclines over the years, common clinical pathogens are seriously resistant to this product, including Gra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C237/26C07C231/24A61K31/65A61K9/19A61J3/02A61P31/00A61P31/04
Inventor 韩宇东许礼贵
Owner HAIKOU QILI PHARMA
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