Pharmaceutical composition for treating oral ulcer and Behcet syndrome
A oral ulcer and composition technology, applied in the field of traditional Chinese medicine composition, can solve problems such as unknown drug mechanism of action, superinfection, and batch-to-batch difference in curative effect
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Embodiment 1
[0018] Take 1.0Kg of licorice, crush it, extract with 8 times the amount (W / V) of 60% ethanol under reflux for 2 hours, filter, add 6 times the amount (W / V) of 60% ethanol to the residue and extract under reflux for 2 hours, filter, combine the filtrates, and depressurize Concentrate until the specific gravity is 1.10 (20°C), add concentrated sulfuric acid dropwise to pH 1.0-1.5, let stand overnight, wash the precipitate with water three times, then dry to obtain the licorice extract, the content of glycyrrhizic acid detected by HPLC is 30%, and set aside. Get 2.0Kg of Flos Lonicerae, pulverize, use 8 times of amount (W / V) 60% ethanol to reflux extract 2h, filter, filter residue adds 6 times of amount (W / V) 60% ethanol reflux to extract 2 hours again, filter, combine filtrate, reduce Concentrate under pressure to a specific gravity of 1.06 (20°C), add to the pretreated macroporous adsorption resin, add water to elute, collect the eluate, concentrate under reduced pressure, and ...
Embodiment 2
[0022] Take 1.0Kg of licorice, crush it, add 2500mL of 0.5% dilute ammonia water, percolate at room temperature for 24h, collect the percolate, concentrate under reduced pressure to 500mL, add concentrated sulfuric acid to adjust the pH to 1.5, separate the precipitate, wash 3 times with water, and dry , the content of glycyrrhizic acid detected by HPLC was 35%, and it was set aside. Take 1 kg of honeysuckle, add (15, 10) times the amount of water, extract twice at 80-90 ° C, 2 hours each time, filter, combine the filtrate, concentrate the filtrate to 2 / 5 of the original volume, add 20% milk of lime Adjust the pH value to 10-12, let it stand for 12 hours, take the precipitate, add 2 times the amount of 95% ethanol to suspend, add 50% sulfuric acid to adjust the pH value to 3-4, stir well, and centrifugally filter the filtrate to adjust the pH value to 6 with 40% NaOH ~7. Recover ethanol under reduced pressure. When the specific gravity reaches 1.0, adjust the pH to 2 with hydr...
Embodiment 3-8
[0026] Take the various extracts obtained in Example 1, mix them according to the ratios in the table below, dissolve them in 95% ethanol, filter through filter paper, add distilled water to 100 mL, and then prepare a liquid spray.
[0027]
[0028] The method of use of this spray is: spray on the affected area several times a day.
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