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Pharmaceutical composition for treating oral ulcer and Behcet syndrome

A oral ulcer and composition technology, applied in the field of traditional Chinese medicine composition, can solve problems such as unknown drug mechanism of action, superinfection, and batch-to-batch difference in curative effect

Inactive Publication Date: 2009-10-28
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many medicines for the treatment of this disease both at home and abroad, but all of them are unsatisfactory. For example, the cauterization method is only suitable for light ulcers with a small number of small areas, and the patient has a stronger pain during burning; Due to the single formula, the effect is poor; the application of a large number of antibiotics will cause superinfection, resulting in pseudomembranous stomatitis and enteritis; systemic application of adrenocortical hormone can satisfactorily control the symptoms, but there is no radical effect, and long-term application will produce gastrointestinal reactions and low immune function of the body; local application can improve symptoms, but it is easy to relapse after discontinuation; immunosuppressants such as azathioprine are not accepted by patients due to large side effects; commonly used traditional Chinese medicine preparations are difficult to control the quality of drugs The shortcoming of monitoring and monitoring often causes differences in curative effect between batches, making it difficult to enter the international market. In addition, the mechanism of action of traditional Chinese medicine compound drugs is unknown, which hinders the entry into the international market
For example, the commonly used Bingboran powder is composed of borax, borneol, xuanming powder, and cinnabar. It has a certain clinical effect, but when the drug is applied to the affected area, the patient often feels pain and refuses to use it again. It is difficult to maintain the treatment, and the mechanism of drug action is unknown.

Method used

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  • Pharmaceutical composition for treating oral ulcer and Behcet syndrome
  • Pharmaceutical composition for treating oral ulcer and Behcet syndrome
  • Pharmaceutical composition for treating oral ulcer and Behcet syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 1.0Kg of licorice, crush it, extract with 8 times the amount (W / V) of 60% ethanol under reflux for 2 hours, filter, add 6 times the amount (W / V) of 60% ethanol to the residue and extract under reflux for 2 hours, filter, combine the filtrates, and depressurize Concentrate until the specific gravity is 1.10 (20°C), add concentrated sulfuric acid dropwise to pH 1.0-1.5, let stand overnight, wash the precipitate with water three times, then dry to obtain the licorice extract, the content of glycyrrhizic acid detected by HPLC is 30%, and set aside. Get 2.0Kg of Flos Lonicerae, pulverize, use 8 times of amount (W / V) 60% ethanol to reflux extract 2h, filter, filter residue adds 6 times of amount (W / V) 60% ethanol reflux to extract 2 hours again, filter, combine filtrate, reduce Concentrate under pressure to a specific gravity of 1.06 (20°C), add to the pretreated macroporous adsorption resin, add water to elute, collect the eluate, concentrate under reduced pressure, and ...

Embodiment 2

[0022] Take 1.0Kg of licorice, crush it, add 2500mL of 0.5% dilute ammonia water, percolate at room temperature for 24h, collect the percolate, concentrate under reduced pressure to 500mL, add concentrated sulfuric acid to adjust the pH to 1.5, separate the precipitate, wash 3 times with water, and dry , the content of glycyrrhizic acid detected by HPLC was 35%, and it was set aside. Take 1 kg of honeysuckle, add (15, 10) times the amount of water, extract twice at 80-90 ° C, 2 hours each time, filter, combine the filtrate, concentrate the filtrate to 2 / 5 of the original volume, add 20% milk of lime Adjust the pH value to 10-12, let it stand for 12 hours, take the precipitate, add 2 times the amount of 95% ethanol to suspend, add 50% sulfuric acid to adjust the pH value to 3-4, stir well, and centrifugally filter the filtrate to adjust the pH value to 6 with 40% NaOH ~7. Recover ethanol under reduced pressure. When the specific gravity reaches 1.0, adjust the pH to 2 with hydr...

Embodiment 3-8

[0026] Take the various extracts obtained in Example 1, mix them according to the ratios in the table below, dissolve them in 95% ethanol, filter through filter paper, add distilled water to 100 mL, and then prepare a liquid spray.

[0027]

[0028] The method of use of this spray is: spray on the affected area several times a day.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating oral ulcer and Behcet syndrome, which is made from the following components: 60 to 80 percent of flos lonicerae extract, 19.8 to 34 percent of glycyrrhiza glabra extract, 0.1 to 3 percent of Chan-Su extraction and 0.1 to 3 percent of common threewingnut root extract. The dosage form of the pharmaceutical composition can be tablet, powder, sticking film, spraying agent and the like and the pharmaceutical composition can be applied to treating oral ulcer, sore throat, Behcet syndrome and other diseases. The pharmaceutical composition can relieve inflammation and alleviate pain and is mainly applied to treating autoinmmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and immunity glomerular nephritis clinically. In addition, the common threewingnut root is clinically applied to treating Behcet syndrome according to reports.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a medicine for treating oral ulcer and Behcet's syndrome, which is a variety of dosage forms prepared from pure traditional Chinese medicine. technical background [0002] Oral ulcers and Behcet's syndrome are multiple diseases that seriously endanger human health. At present, the incidence of oral ulcers and Behcet's syndrome in the world is about 15-20%. increasing trend. Oral chronic ulcers that do not heal for a long time can lead to various complications, such as malnutrition, superinfection, cancer, etc. Therefore, early treatment plays a vital role in clinical treatment. [0003] At present, the etiology of recurrent oral ulcer and Behcet's disease is not very clear. Some people think that it is caused by viral infection or allergic reaction to infectious factors, and some people think that it is closely related to immunity. That is, due to various factors, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P1/02A61P11/04A61K35/56A61K35/65
Inventor 敖明章余龙江栗茂腾马素燕李为
Owner HUAZHONG UNIV OF SCI & TECH
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