Child cough granule and preparation method of same

A pediatric and granule technology, applied in the field of medicine, can solve the problems of increasing the safety hazards of syrup medication, not following the minimum dosage, and inconvenient for patients to use and carry, so as to improve quality controllability and stability, and avoid adverse reactions. , the curative effect is reliable

Inactive Publication Date: 2009-11-11
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] ①The use of preservatives increases the potential safety hazards of the syrup
[0008] ②The commercially available syrup is packaged as 120ml per bottle, and the dosage is 5-10ml each time, so multiple openings cause secondary pollution of the syrup
[0009] ③ Commercially available syrups are not packaged according to the minimum dosage, and the dosage is not accurate
[0010] ④The commercially available syrups are all packaged in glass bottles, which increases production and transportation costs, and is inconvenient for patients to use and carry
[0011] In addition to the defects in the dosage form, the commercially available cough syrup for children adds sodium benzoate as a preservative. It has been reported in the literature that sodium benzoate affects the absorption of drugs and has adverse reactions, including vomiting, hyperglycemia, hypokalemia, convulsions and mental impairment Wait

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] prescription:

[0049] Licorice Liquid Extract 150ml

[0050] Bellflower Liquid Extract 30ml

[0051] Ammonium chloride 10g

[0052] Orange peel tincture 20ml

[0053] Starch 350g

[0054] Dextrin 350g

[0055] Sucrose powder 210g

[0056]

[0057] Made into 1000g (5g / bag)

[0058] Preparation method:

[0059] Mix licorice liquid extract, platycodon grandiflora liquid extract, and orange peel tincture according to the prescription amount; grind and sieve ammonium chloride, starch, and dextrin, and then mix them uniformly according to the prescription amount; Add the liquid ingredients evenly into the solid mixed powder, mix until the color is uniform, bake at 55°C until the water content is less than 10%, grind it through a 100-mesh sieve, and set aside; grind the sucrose powder through a 100-mesh sieve, weigh the prescription amount and mix it with the above powder Uniform, soft material made of 20% ethanol, 18-mesh sieve to...

Embodiment 2

[0061] prescription:

[0062] Licorice Liquid Extract 150ml

[0063] Bellflower Liquid Extract 30ml

[0064] Ammonium chloride 10g

[0065] Orange peel tincture 20ml

[0066] Starch 350g

[0067] Lactose 350g

[0068] Sucrose powder 210g

[0069]

[0070] Made into 1000g (5g / bag)

[0071] Preparation method:

[0072] Mix licorice liquid extract, platycodon grandiflora liquid extract, and orange peel tincture according to the prescription amount; grind and sieve ammonium chloride, starch, and lactose, and then mix them evenly according to the prescription amount; put the above mixed liquid Add the ingredients evenly into the solid mixed powder, mix until the color is uniform, bake at 90°C until the water content is less than 5%, crush it through a 100 mesh sieve, and set aside; crush the sucrose powder through a 100 mesh sieve, weigh the prescription amount and mix it with the above powder evenly , soft material made of 50% ethanol,...

Embodiment 3

[0074] prescription:

[0075] Licorice Liquid Extract 150ml

[0076] Bellflower Liquid Extract 30ml

[0077] Ammonium chloride 10g

[0078] Orange peel tincture 20ml

[0079] Starch 350g

[0080] Microcrystalline Cellulose 350g

[0081] Sucrose powder 210g

[0082]

[0083] Made into 1000g (5g / bag)

[0084] Preparation method:

[0085] Mix licorice liquid extract, platycodon grandiflora liquid extract, and orange peel tincture according to the prescription amount; grind and sieve ammonium chloride, starch, and microcrystalline cellulose, and then mix them evenly according to the prescription amount; Evenly add the liquid ingredients into the solid mixed powder, mix until the color is uniform, bake at 65°C until the water content is less than 8%, crush through a 100-mesh sieve, and set aside; crush the sucrose powder through a 100-mesh sieve, weigh the recipe amount and the above Mix the powder evenly, make soft material with 30% et...

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PUM

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Abstract

The invention discloses a child cough granule prescription used for eliminating phlegm and relieving cough for children and a preparation method of the product. The preparation method is characterized in that the child cough granule is prepared by choosing proper excipients on the basis of maintaining the base prescription of child cough syrup. The invention provides a novel preparation formulation which is taken more conveniently and safely and has same curative effect for clinical medication, and has good controllability and stability of preparation technology quality.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a prescription of Xiaoerzhike granules and a preparation method thereof. Background technique [0002] Among all the diseases in childhood, respiratory system infection plays a significant role: it not only has a high incidence rate, but also has a wide range of diseases. If the disease is not treated in time or treated poorly, it may also cause pharyngitis, otitis media, bronchitis, bronchitis, etc. Inflammation, asthma, pneumonia and other symptoms. According to statistics, the birth rate in 2006 was 12.09‰, the annual birth population was 15.84 million, and the number of children under the age of 14 was as high as 265 million, accounting for 20.3% of the total population; more than 90% of children suffered from fever at least 5 times a year, clinically used Dosage forms of cough, diarrhea, stagnation and other symptoms, and due to untimely treatment or poor treatment of cough ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/16A61K47/40A61P11/14A61K33/00
Inventor 陈华张慧英张玲玲
Owner 北京瑞伊人科技发展有限公司
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