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Medicine for treating allergic rhinitis and preparation method thereof

A technology for allergic rhinitis and drugs, which is applied in the field of drugs for treating allergic rhinitis and its preparation, can solve the problems of unsatisfactory curative effect and large side effects of antihistamine drugs, and achieve good therapeutic effect, reasonable composition of raw materials, and fluidity Good results

Inactive Publication Date: 2009-12-02
JIAOZUO XIANDA TRADE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, antihistamines generally have large side effects and unsatisfactory curative effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The composition of raw materials is as follows:

[0030] Rupatadine Fumarate 10g

[0031] Pregelatinized starch 12.0g

[0032] Microcrystalline Cellulose 4.0g

[0033] 3% hypromellose solution 2.5g

[0034] Sodium carboxymethyl starch 0.5g

[0035] Magnesium stearate 0.1g

[0036] Get each raw material, require that other each raw material except 3% hypromellose solution can pass through 80 mesh sieves, put rupatadine fumarate, pregelatinized starch, microcrystalline cellulose in the boiling granulator In the fluidized bed, adjust the air pressure to 0.5MPa, spray 3% hypromellose solution at a speed of 230ml / min; control the inlet air temperature to 100°C, the outlet air temperature to 45°C, and turn off peristalsis after 50 minutes of boiling granulation Pump; continue drying for 15 minutes and pass through a 14-mesh sieve for granulation; add sodium carboxymethyl starch and magnesium stearate, and mix in a two-dimensional mixing machine for 15 minutes; press the ...

Embodiment 2

[0039] The composition of raw materials is as follows:

[0040] Rupatadine Fumarate 10.0g

[0041] Pregelatinized starch 10.0g

[0042] Microcrystalline Cellulose 3.0g

[0043] 3% hypromellose solution 2.0g

[0044] Sodium carboxymethyl starch 0.4g

[0045] Magnesium stearate 0.05g

[0046] Get each raw material, require that other each raw material except 3% hypromellose solution can pass through 80 mesh sieves, put rupatadine fumarate, pregelatinized starch, microcrystalline cellulose in the boiling granulator In the fluidized bed, adjust the air pressure to 0.3MPa, spray 3% hypromellose solution at a speed of 180ml / min; control the inlet air temperature to 80°C, the outlet air temperature to 35°C, and turn off the peristalsis after 60 minutes of boiling granulation Pump; continue to dry for 20 minutes and pass through a 14-mesh sieve for granulation; add sodium carboxymethyl starch and magnesium stearate, and mix in a two-dimensional mixing machine for 20 minutes; pres...

Embodiment 3

[0048] The composition of raw materials is as follows:

[0049] Rupatadine Fumarate 10.0g

[0050] Pregelatinized starch 12.0g

[0051] Microcrystalline Cellulose 5.0g

[0052] 3% hypromellose solution 3.0g

[0053] Sodium carboxymethyl starch 0.6g

[0054] Magnesium stearate 0.1g

[0055] Get each raw material, require that other each raw material except 3% hypromellose solution can pass through 80 mesh sieves, put rupatadine fumarate, pregelatinized starch, microcrystalline cellulose in the boiling granulator In the fluidized bed, adjust the air pressure to 0.3MPa, spray 3% hypromellose solution at a speed of 280ml / min; control the inlet air temperature to 120°C, the outlet air temperature to 45°C, and turn off peristalsis after 40 minutes of boiling granulation Pump; continue drying for 10 minutes and pass through a 14-mesh sieve for granulation; add sodium carboxymethyl starch and magnesium stearate, and mix in a two-dimensional mixing machine for 10 minutes; press th...

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PUM

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Abstract

The invention relates to a medicine for treating allergic rhinitis. The medicine comprises the following raw materials according to parts by weight: 90-110 parts of fumarate rupatadine, 100-130 parts of pregelatinized starch, 30-50 parts of microcrystalline cellulose, 20-30 parts of hydroxypropyl methylcellulose solution of 3 percent, 3-6 parts of sodium carboxymethyl starch and 0.2-2 parts of magnesium stearate. The medicine has simple recipe, reasonable composition of the raw materials and proper proportion, and the dissolution degree is enhanced to more than 90 percent from 70 percent; and the effective components can be farthest absorbed by a human body, and a favorable therapeutic effect is achieved.

Description

(1) Technical field [0001] The invention relates to a medicine for treating allergic rhinitis and a preparation method thereof. (2) Background technology [0002] Allergic diseases are common and frequently-occurring diseases, especially allergic rhinitis. At present, the medicines for the clinical treatment of allergic rhinitis in my country mainly include antihistamines chlorpheniramine (chlorpheniramine), astemizole (astemizole), terfenadine (Mintel), cetirizine (Centirizine). Temin), loratadine (Kemineng), etc., there are relatively few varieties. Among them, chlorpheniramine has a strong sedative effect and can cause drowsiness and fatigue; astemizole and Mitel can cause severe cardiotoxicity. Cetirizine and loratadine have gradually occupied the market due to their low cardiotoxicity and few side effects, replacing chlorpheniramine, astemizole, and Mitel. However, antihistamines generally have the problems of large side effects and unsatisfactory curative effects. ...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K47/36A61K9/20A61P11/02A61P37/08
Inventor 陈勇梅拥军杨军强
Owner JIAOZUO XIANDA TRADE
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