Preparation method for compound preparation comprising aspirin and alkaline drugs
A technology for aspirin and alkaline drugs, applied in the field of double-layer coating preparation, which can solve problems such as swelling, easy moisture absorption, and easy layering of double-layer tablets
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Examples
Example Embodiment
[0010] Example 1 of the invention
[0011] Aspirin layer (10000 tablets)
[0012] Aspirin 3300g
[0013] Tartaric acid 33g
[0014] Sodium Carboxymethyl Starch 80g
[0015] Silica 50g
[0016] Buffer layer (10000 pieces)
[0017] Hydrotalcite 1000g
[0018] Compressible starch 500g
[0019] 10% PVPk30 90% ethanol solution 1500ml
[0020] Silica 15g
[0021] Coating liquid (10000 tablets)
[0022] Hydroxypropyl methylcellulose 150g
[0023] Ethyl cellulose 30g
[0024] Polyethylene glycol 50g
[0025] Titanium dioxide 20g
[0026] 85% ethanol 3000ml
[0027] Preparation method: Mix the prescription amount of aspirin and tartaric acid, press into 10 mesh granules by a dry granulator, and then mix them with sodium carboxymethyl starch and silicon dioxide to form aspirin layer granules; mix the hydrotalcite and compressible starch After homogenization, the soft material is made with 10% PVPk30 and 90% ethanol solution, granulated by 18# mesh, and the wet granules are dried at 80℃ to obtain buffer laye...
Example Embodiment
[0028] Example 2 of the invention
[0029] Aspirin layer (10000 tablets)
[0030] Aspirin 3000g
[0031] Starch 495g
[0032] Tartaric acid 33g
[0033] Silica 50g
[0034] Buffer layer (10000 pieces)
[0035] Hydrotalcite 1000g
[0036] Starch 500g
[0037] 10% PVPk30 90% ethanol solution 1500ml
[0038] Silica 15g
[0039] Coating liquid (10000 tablets)
[0040] Hydroxypropyl methylcellulose 150g
[0041] Ethyl cellulose 30g
[0042] Polyethylene glycol 50g
[0043] Titanium dioxide 20g
[0044] 85% ethanol 3000ml
[0045] Preparation method: Mix the prescription amount of aspirin, starch, and tartaric acid, press into 10 mesh granules by a dry granulator, add silicon dioxide and mix as aspirin granules; mix the hydrotalcite and starch with 90% of 10% PVPk30 The soft material is made of ethanol solution, granulated by 18# mesh, and the wet granules are dried at 80°C to obtain dry granules; the two-layer granules are compressed into double-layer tablets by a double-layer tablet press; the double-...
Example Embodiment
[0046] Example 3 of the invention
[0047] Aspirin layer (10000 tablets)
[0048] Aspirin 5000g
[0049] Compressible starch 430g
[0050] Citric acid 33g
[0051] Low-substituted hydroxypropyl cellulose 65g
[0052] Sodium lauryl sulfate 50g
[0053] Buffer layer (10000 pieces)
[0054] Calcium carbonate 450g
[0055] Magnesium oxide 550g
[0056] Lactose 500g
[0057] 10% PVPk30 90% ethanol solution 1500ml
[0058] Sodium lauryl sulfate 15g
[0059] Coating liquid (10000 tablets)
[0060] Hydroxypropyl methylcellulose 250g
[0061] Ethyl cellulose 60g
[0062] Glycerin 80g
[0063] Titanium dioxide 20g
[0064] 85% ethanol 5000ml
[0065] Preparation method: Mix the prescription amount of aspirin, compressible starch, and tartaric acid, press into 10 mesh granules by a dry granulator, then add low-substituted hydroxypropyl methyl cellulose and sodium lauryl sulfate and mix evenly. Aspirin layer granules; after mixing calcium carbonate and magnesium oxide with starch, make soft material with 10% PV...
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