Losartan potassium hydrochlorothiazide composition and preparation method thereof
A technology of losartan potassium hydrochlorothiazide and losartan potassium, which is applied in the field of losartan potassium hydrochlorothiazide tablets and its preparation, can solve unrealistic problems such as getting the best or better control of hypertensive patients, and achieve The effect of simple operation and mature technology
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[0034] Example 1
[0035] (1) Prescription
[0036] Chip composition
[0037] Composition 1
[0038] Losartan Potassium 50g
[0039] Lactose 50g
[0040] Composition 2
[0041] Hydrochlorothiazide 12.5g
[0042] Croscarmellose Sodium 10g
[0043] Microcrystalline Cellulose 60g
[0044] 15g pregelatinized starch
[0045] Composition 3
[0046] Magnesium Stearate 1g
[0047] Coating Composition
[0048] Coating powder (stomach dissolving type) 5g
[0049] 50% ethanol solution 50ml
[0050] Makes 1000 pieces
[0051] (2) Preparation method
[0052]1) Pulverize losartan potassium and hydrochlorothiazide respectively, sieve, and set aside; pass microcrystalline cellulose, lactose, croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, and magnesium stearate sieve, spare;
[0053] 2) Weigh the raw and auxiliary materials according to the prescription amount respectively, and set aside;
[0054] 3) Take the raw and auxiliary materials of compositio...
Example Embodiment
[0057] Embodiment 2 (comparative example)
[0058] (1) Prescription
[0059] Chip composition
[0060] Losartan Potassium 50g
[0061] Hydrochlorothiazide 12.5g
[0062] Lactose 50g
[0063] Croscarmellose Sodium 10g
[0064] Microcrystalline Cellulose 60g
[0065] 15g pregelatinized starch
[0066] Magnesium Stearate 1g
[0067] Coating Composition
[0068] Coating powder (stomach dissolving type) 5g
[0069] 50% ethanol solution 50ml
[0070] Makes 1000 pieces
[0071] (2) Preparation method
[0072] 1) Pulverize losartan potassium and hydrochlorothiazide respectively, sieve, and set aside; pass microcrystalline cellulose, lactose, croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, and magnesium stearate sieve, spare;
[0073] 2) Weigh the raw and auxiliary materials according to the prescription amount respectively, and set aside;
[0074] 3) Take the raw and auxiliary materials in 2) and use 50% ethanol solution to granulate with a 24-m...
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