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Losartan potassium hydrochlorothiazide composition and preparation method thereof

A technology of losartan potassium hydrochlorothiazide and losartan potassium, which is applied in the field of losartan potassium hydrochlorothiazide tablets and its preparation, can solve unrealistic problems such as getting the best or better control of hypertensive patients, and achieve The effect of simple operation and mature technology

Active Publication Date: 2010-01-27
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for now, when emphasizing individualized medication, it must be noted that although individualized medication can best control a patient's blood pressure, it cannot guarantee that every hypertensive patient's medication can be individualized and get the best results. Best or better control, it seems unrealistic to use individualized medicine for all patients

Method used

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  • Losartan potassium hydrochlorothiazide composition and preparation method thereof
  • Losartan potassium hydrochlorothiazide composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Prescription

[0036] Chip composition

[0037] Composition 1

[0038] Losartan Potassium 50g

[0039] Lactose 50g

[0040] Composition 2

[0041] Hydrochlorothiazide 12.5g

[0042] Croscarmellose Sodium 10g

[0043] Microcrystalline Cellulose 60g

[0044] 15g pregelatinized starch

[0045] Composition 3

[0046] Magnesium Stearate 1g

[0047] Coating Composition

[0048] Coating powder (stomach dissolving type) 5g

[0049] 50% ethanol solution 50ml

[0050] Makes 1000 pieces

[0051] (2) Preparation method

[0052]1) Pulverize losartan potassium and hydrochlorothiazide respectively, sieve, and set aside; pass microcrystalline cellulose, lactose, croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, and magnesium stearate sieve, spare;

[0053] 2) Weigh the raw and auxiliary materials according to the prescription amount respectively, and set aside;

[0054] 3) Take the raw and auxiliary materials of composition 1 and composition ...

Embodiment 2

[0057] Embodiment 2 (comparative example)

[0058] (1) Prescription

[0059] Chip composition

[0060] Losartan Potassium 50g

[0061] Hydrochlorothiazide 12.5g

[0062] Lactose 50g

[0063] Croscarmellose Sodium 10g

[0064] Microcrystalline Cellulose 60g

[0065] 15g pregelatinized starch

[0066] Magnesium Stearate 1g

[0067] Coating Composition

[0068] Coating powder (stomach dissolving type) 5g

[0069] 50% ethanol solution 50ml

[0070] Makes 1000 pieces

[0071] (2) Preparation method

[0072] 1) Pulverize losartan potassium and hydrochlorothiazide respectively, sieve, and set aside; pass microcrystalline cellulose, lactose, croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, and magnesium stearate sieve, spare;

[0073] 2) Weigh the raw and auxiliary materials according to the prescription amount respectively, and set aside;

[0074] 3) Take the raw and auxiliary materials in 2) and use 50% ethanol solution to granulate with a 24-m...

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Abstract

The invention relates to a losartan potassium hydrochlorothiazide tablet and a preparation method thereof. The losartan potassium hydrochlorothiazide tablet comprises a tablet core and a film coating layer and is characterized in that the tablet core consists of losartan potassium and hydrochlorothiazide which are respectively mixed with available pharmaceutic adjuvants, wherein the pharmaceutic adjuvants include microcrystalline cellulose, crosslinked sodium carboxymethylcellulose, pregelatinized starch, lactose, polyvinylpyrrolidone, starch, magnesium stearate and talcum powder. After the adoption of a separate pelletizing process for uniform mixing, tabletting is carried out, therefore relatively low dissolution rate which is caused by the medicinal interaction during once pelletizing can be avoided, in-vitro dissolution rate can be greatly improved, and then the bioavailability can be improved.

Description

technical field [0001] The invention relates to a Losartan Potassium Hydrochlorothiazide Tablet and a preparation method thereof. The separate granulation process is adopted to avoid the low dissolution rate caused by drug interaction in one-time granulation, and can greatly improve the in vitro dissolution rate, thereby improving the bioavailability. Background technique [0002] Hypertension is the most common cardiovascular disease in the world, and its prevalence rate is as high as 10%-20%. It can lead to heart, cerebrovascular and kidney lesions, and is one of the main diseases that endanger human health. During the ten years from 1979 to 1991, the prevalence of hypertension in my country increased by 25%. According to the forecast of the World Health Organization, in 2020, non-infectious diseases will account for 79% of the causes of death in my country, and cardiovascular diseases will rank first. It has been reported that antihypertensive treatment will definitely ...

Claims

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Application Information

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IPC IPC(8): A61K31/549A61K31/4178A61K9/28A61P9/12
Inventor 严洁黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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