Baicalin adhesion type nanometer eye drops and preparation method thereof
A baicalin sticky and eye drop technology is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, which can solve the problems of loss of baicalin, low bioavailability, etc. Corneal absorption, increasing drug concentration, and increasing curative effect
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Embodiment 1
[0034] Add 7g of poloxamer to 500g of deionized water, and dissolve it in a water bath at 70°C as the water phase; in addition, dissolve 0.08g of baicalin, 5g of glyceryl tristearate, and 5g of soybean lecithin in an appropriate amount of absolute ethanol, and heat to make the ethanol Evaporate to form the organic phase; the organic phase is magnetically stirred in a water bath, slowly inject the water phase into the stirred organic phase, and continue to stir for 0.5h to form colostrum; put the obtained colostrum in a high-pressure homogenizer, 700bar homogenization 3 times, after filtering through a microporous membrane, add 5g hydroxypropyl methylcellulose, 0.1g benzalkonium bromide, 8g sodium chloride, 40g hydroxypropyl-β-cyclodextrin and stir to dissolve, and dissolve with 10% Sodium hydroxide is used to adjust the pH to 6.8, the solution is filtered through a microporous membrane, and then deionized water is added from the filter to reach the total amount.
Embodiment 2
[0036] Add 100g of poloxamer to 500g of deionized water, and dissolve it in a water bath at 70°C as the water phase; in addition, dissolve 10g of baicalin, 50g of glyceryl tristearate, and 50g of soybean lecithin in an appropriate amount of absolute ethanol, and heat to evaporate the ethanol. to form the organic phase; the organic phase is magnetically stirred in a water bath, the water phase is slowly injected into the stirred organic phase, and the stirring is continued for 0.5h to form colostrum; the resulting colostrum is placed in a high-pressure homogenizer, 700bar homogeneous Once, after filtering through a microporous membrane, add 100g hydroxypropyl methylcellulose, 0.1g benzalkonium bromide, 8g sodium chloride, 40g hydroxypropyl-β-cyclodextrin and stir to dissolve, and use 10% hydrogen Sodium oxide is used to adjust the pH to 6.8, the solution is filtered through a microporous membrane, and deionized water is added from the filter to reach the total amount.
Embodiment 3
[0038] Add 100g of poloxamer to 300g of deionized water, and dissolve it in a water bath at 70°C as the water phase; in addition, dissolve 16g of baicalin, 70g of glyceryl tristearate, and 60g of soybean lecithin in an appropriate amount of absolute ethanol, and heat to evaporate the ethanol. to form the organic phase; the organic phase is magnetically stirred in a water bath, the water phase is slowly injected into the stirred organic phase, and the stirring is continued for 0.5h to form colostrum; the resulting colostrum is placed in a high-pressure homogenizer, 700bar homogeneous Once, after filtering through a microporous membrane, add 150g of hydroxypropylmethylcellulose, 0.1g of benzalkonium bromide, 8g of sodium chloride, and 100g of hydroxypropyl-β-cyclodextrin and stir to dissolve, and then use 10% hydrogen Sodium oxide is used to adjust the pH to 6.8, the solution is filtered through a microporous membrane, and deionized water is added from the filter to reach the tot...
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Abstract
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