Application of tetracyclic triterpenoids compound in preparing anti-angiogenic drugs

An angiogenesis and drug technology, applied in the field of application of cucurbitacin E in the preparation of anti-angiogenesis drugs, can solve the problems of lack of cucurbitacin E, etc.
CN101647801AInactive Publication Date: 2010-02-17EAST CHINA NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
EAST CHINA NORMAL UNIVERSITY
Publication Date
2010-02-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides the application of tetracyclic triterpenoids compound cucurbitacins E in preparing anti-angiogenic drugs. The cucurbitacins E can inhibit tumor angiogenesis, arthritis pathological tissue vessel angiogenesis, neovascular eye disease, hemangioma pathological tissue angiogenesis, psoriasis pathological tissue vessel angiogenesis, solid tumor pathological tissue angiogenesis, hemangioma, Kaposi' s sarcoma pathological tissue angiogenesis, leukocythemia, lymphadenoma, myeloma blood cancer and Paget' s disease angiogenesis. The invention also provides the application of a compound containing effective dose of cucurbitacins E and pharmacy acceptable ingredients in preparing the anti-angiogenic drugs.
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Description

technical field

[0001] The invention relates to a new application of a tetracyclic triterpenoid compound cucurbitacin E (Cucurbitacin E), in particular to the application of the cucurbitacin E in the preparation of drugs for inhibiting angiogenesis. Background technique

[0002] Angiogenesis is the process of generating new blood vessels on the basis of existing blood vessels. Angiogenesis has multiple steps: proliferation, migration, invasion and microtubule formation of vascular endothelial cells, recruitment of perivascular cells and acquisition of new matrix membrane.

[0003] Angiogenesis usually occurs only in the embryo and later in embryonic development, the reproductive cycle and wound healing. In pathological conditions (solid tumor invasion, migration, diabetic retinopathy, hemangioma, arthritis, psoriasis and atherosclerosis, etc.), the disease is associated with persistent angiogenesis.

[0004] Malignant tumors pose a great threat to human health for a long t...

Claims

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