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Surgery anti-adhesion agent and preparation method thereof

An anti-adhesion agent and a surgical technique, which can be applied to surgical drugs, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as easy deformation, brittleness, and limit tissue adhesion prevention, and achieve good anti-adhesion effects. , good stability effect

Inactive Publication Date: 2010-03-17
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it is easily decomposed and absorbed in the body, the anti-tissue adhesion effect is limited
In order to improve the easy decomposition of hyaluronic acid in the body, the U.S. Patent (Patent No. 6,387,413B1) adopted the method of grafting hyaluronic acid with a polymer compound (Carboxymethyl cellulose, CMC) to delay its decomposition speed in the body. The anti-adhesion prepared by this method Although the cellulose in the membrane is a natural polymer material, because it is not a substance in the body, when it is injected into the body, it reacts with some substances in the body, causing adverse reactions, and there is no enzyme in the body to decompose it, so it is hydrolyzed , After oxidation treatment, it can be used in the body
U.S. Patent (Patent No. 5,017,229) disclosed the technology of using hyaluronic acid to graft CMC (Carboxymethyl cellulose) polymer materials through EDC[1-ethyl-3(3-dimethylaminopropyl)carbodilimidehydrochloride] to prepare a hydrophobic anti-adhesive film technology. It is formed by the combination of positive and negative charges between compounds. The anti-adhesion film is not easy to decompose and has anti-adhesion effect, but the EDC chemical substance is toxic to the human body, and it takes a long time for special treatment to remove it
In addition, the biggest disadvantage of the anti-tissue adhesion film is that it is very brittle when dry, easily broken, and easily deformed when exposed to moisture. It is difficult to put the film into the body cavity during surgery with gloves
[0004] In summary, although the currently developed anti-adhesion materials have anti-adhesion properties, it is difficult to remove the anti-adhesion materials prepared by chemical methods to promote the synthesis of chemical additives, so their toxicity and safety issues have restricted their wide clinical application. the bottleneck

Method used

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  • Surgery anti-adhesion agent and preparation method thereof
  • Surgery anti-adhesion agent and preparation method thereof
  • Surgery anti-adhesion agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The effect of different concentrations of hyaluronic acid on the anti-adhesion effect:

[0018] Take the molecular weight as 3×10 6 Dalton and hyaluronic acid with a viscosity of 35dl / g were dissolved in physiological saline to prepare solution A with a weight concentration of 0.5%, and placed in a low-temperature refrigerator at 4°C for 48 hours to obtain a hyaluronic acid gum composition. Application and comparison results are shown in Table 1.

Embodiment 2

[0020] Same as Example 1, the weight concentration of solution A is 1%, and the application and comparison results are shown in Table 1.

experiment example 3

[0024] Rat intestinal adhesion test method:

[0025] Rats were anesthetized by intraperitoneal injection of sodium pentobarbital (30 mg / kg). When the animals were quiet, breathing was stable and balanced, blood pressure was normal, the wall muscles were relaxed, and the corneal reflexes were dull, various test operations could be performed. After the animal is anesthetized, the animal is fixed in the supine position, sheared and disinfected. Under aseptic operation, remove the midline incision of the abdomen, about 3-4 cm long. After opening the abdominal cavity, find out the cecum part, and gently wipe the cecum with dry gauze until the serosal layer of the intestine is affected. Damage (1.2cm×1.2cm) (the surface has a large blood spot on the needle tip, and the gauze is dyed light red). Use a scoop on the wall of the abdominal cavity opposite the injury site to an area as large as the injury. Fix the cecal injury site at two places 1cm away from the abdominal cavity wall that ...

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Abstract

The invention belongs to the technical field of surgery medical material, and more particularly relates to a surgery anti-adhesion agent and a preparation method thereof. The surgery anti-adhesion agent takes hyaluronic acid with the molecular weight range of 0.8*10<6>-3*10<6> daltons and the viscosity of 30dl / g-35dl / g and hydroxyl starch with the molecular weight range of 7*10<4>-6.7*10<5> daltons and the water substitution degree of 0.4-0.75 as raw materials, wherein the weight ratio between the high viscosity hyaluronic acid and the hydroxyl starch is 1:30, and the surgery anti-adhesion agent is prepared by taking physiological saline as solvent and mixing the physiological saline and the raw materials. The invention uses no chemical additive, is different from the mixture anti-adhesionagent which has conventional physical barrier and anti-adhesion effect and can be used between high polymer materials, and not only has the physical barrier, but also has the novel anti-adhesion function for preventing blood clots which cause tissue adhesion from forming. Furthermore, the surgery anti-adhesion agent is also different from the market products, and has the advantages of good anti-adhesion effect and stability.

Description

Technical field [0001] The invention belongs to the technical field of surgical medical materials, and in particular relates to an anti-adhesion agent that utilizes biocompatible hyaluronic acid and a polymer compound to form an anti-adhesion agent with good anti-adhesion effect on surgical tissues and a preparation method thereof. Background technique [0002] Tissue adhesion (adhesion) is a wound caused by inflammation, friction, surgery, etc., in the process of treatment, excessive fibrous tissue is produced or blood clots are formed by bleeding, which causes adhesion of surrounding organs and tissues. This phenomenon is very easy to occur after surgical operations such as human abdominal cavity, cardiovascular, spine, bone and joint, and gynecological pelvic cavity. Among them, the incidence of adhesions in the abdominal cavity and pelvic cavity is as high as 90% or more. About 20% of female infertility patients are caused by pelvic adhesions. 30% of adhesions have obvious sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61K31/718A61P41/00
Inventor 蒋革冯宝民王惠国冯晓娜
Owner DALIAN UNIV
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