Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New usage of zedoary cyclic diolefine

A technology for cyclodiene and medicament of turmeric, applied in the field of cyclodiene derivatives of turmeric, can solve the problems of yellowing, cyclodiene of turmeric is unstable, easy to decompose, etc., achieves short operation period, avoids decomposition and transformation , the effect of high degree of separation

Active Publication Date: 2010-03-24
HAINAN BIKAI PHARM CO LTD
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Curcuma cyclodiene is the main component of zedoary volatile oil, but there is no method for preparing this compound in large quantities at present, and cyclodiene pentazodiene is unstable, and it is easy to decompose and turn yellow when heated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New usage of zedoary cyclic diolefine
  • New usage of zedoary cyclic diolefine
  • New usage of zedoary cyclic diolefine

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0023] Preparation Example 1: Preparation of Potentiocycladiene

[0024] Take 1.5 kg of curcuma medicinal material, grind it into coarse powder (pass through No. 2 sieve), put it into the HA221-50-06 supercritical extraction device, under the pressure of 28Mpa, 60 ℃, CO 2 The flow rate was 25kg / hr and extraction was carried out for 1.5 hours. The pressures of the analysis kettles I and II were 10 and 6Mpa respectively, and the temperatures were 50 and 45°C respectively. 120g of yellow or brown oily extract was obtained by analysis, and the extraction yield was 8.0%. Place the extract in the refrigerator, precipitate crystals and wash with methanol to obtain white needle-like crystals, mp.69-71°C. Identified by UV, IR, NMR, MS and other spectral techniques, the molecular formula C 15 h 20 O, with a molecular weight of 216.32, has a structure of zedoary cyclodiene.

[0025] IR(KBr): 3052, 3027(=CH), 2968, 2928, 2890, 2856, 1622(C=C), 1552(C=C, Furan), 1445, 1385(CH 3 , CH 2...

preparation example 2

[0032] Preparation example 2: preparation of the reference substance of zedoary cyclodiene

[0033] Take 1.5 kg of curcuma medicinal material, grind it into coarse powder (pass through No. 2 sieve), put it into the HA221-50-06 supercritical extraction device, under the pressure of 28Mpa, 60 ℃, CO 2 The flow rate is 25kg / hr and extraction is carried out for 1.5 hours. The pressures of the analysis kettles I and II are respectively 10 and 6Mpa, and the temperatures are respectively 50 and 45°C. After analysis, 120g of yellow or brown oily extract is obtained. Take 60g of 100-200 mesh silica gel, Pack the column by dry method, load 2g of oily extract, elute with 300ml petroleum ether, after the eluent is drained, the silica gel is divided into two distinct colored bands, cut off the red silica gel, add 100ml of ethyl acetate, sonicate for 30min, and filter , repeated 3 times, combined the filtrates, recovered ethyl acetate, added methanol to slightly heat the residue to dissolve ...

preparation example 3

[0034] Preparation Example 3: Preparation of 2-Acetyl-Pengcuracyclodiene

[0035]Add 0.10 mol of zedoary cyclodiene compound, 0.15 mol of aluminum trichloride, and 40 ml of carbon disulfide into a three-necked flask equipped with a reflux condenser and a dropping funnel. Dilute 0.10 mol of acetyl chloride with an appropriate amount of carbon disulfide in the dropping funnel, and slowly add it into the three-necked bottle under mechanical stirring (about 1-2 drops / second). After the addition, stir at room temperature for 2 hours, and react for 2 hours. After the reaction is completed, slowly add about 20ml of concentrated hydrochloric acid diluted with 1:1 (v / v) water to the three-necked flask under ice bath, The solution was layered, and when the solid in the three-necked flask was fully dissolved, it was cooled, transferred to a 500ml separatory funnel and extracted several times with chloroform, discarded the water layer, combined the chloroform layers, added 50ml of 10% NaO...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a new usage of zedoary cyclic diolefine, in particular to application of zedoary cyclic diolefine in preparing antipyretic, anti-inflammatory or antivirotic medicament, and application thereof in preparing medicament for curing influenza viral pneumonia.

Description

technical field [0001] This application is a divisional application of Chinese patent application 200510043886.9. The present invention relates to ponzocyclodiene derivatives, to a preparation method of ponzocyclodiene and derivatives thereof, and to the medical application of ponzocyclodiene and derivatives thereof. Background technique [0002] The traditional Chinese medicine Zezhu is the dry rhizome of Curcuma phaeocaulis Val. Guangxi Zezhu C.kwangsinensis S.G.Lee et C.F.Liang. The ingredients are monoterpene and sesquiterpene compounds, among which sesquiterpene and oxygen-containing sesquiterpene derivatives are the main active ingredients. [0003] Zedoary volatile oil has always been extracted by steam distillation. Since zedoary oil contains more starch grains, it is easy to be evaporated together with water vapor and volatile oil during the long-term heating and distillation process, resulting in a large amount of foam in the extracted volatile oil. Oil and water...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/343A61P29/00A61P31/12A61P11/00A61P31/16
Inventor 孙秀燕
Owner HAINAN BIKAI PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com