Amoxicillin oral disintegrating tablet for domestic fowls and preparation method thereof

Abstract

The invention relates to an amoxicillin oral disintegrating tablet for domestic fowls and a preparation method thereof, wherein the composing components of the amoxicillin oral disintegrating tablet and the parts by weight thereof are respectively that 300-800 parts of amoxicillin, 100-150 parts of clavulanate potassium, 140-200 parts of microcrystalline cellulose, 20-60 parts of low-substituted hydroxypropyl cellulose, 60-120 parts of lactose, 30-80 parts of esibatan, 10-50 parts of milk king essence, 0.5-1.5 parts of saccharin sodium, and 1.5-5 parts of magnesium stearate. The amoxicillin oral disintegrating tablet has the advantages that manufacturing devices are simple, the operation is easy, the weight difference is small, and the cost is low, and breaks the conventional rule of just using freeze-dry technology to produce oral disintegrating tablets, opens up the technology for producing the oral disintegrating tablet just through adopting common powder type granule tablets in China, is an important breakthrough of the processing technology of preparations for oral use in China, and opens new possibilities in emergency treatment of animal drug markets in China.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a compound amoxicillin orally disintegrating tablet for poultry and a preparation method thereof. Background technique [0002] With the rapid development of my country's poultry breeding industry and the continuous development of veterinary drug research, the application of antibiotics in the treatment of various diseases and infections of poultry has become common, which has played a positive role in improving the survival rate and health level of poultry and disease treatment. Maximizing the effectiveness of antibiotics to control disease has always been a challenge. Amoxicillin is a β-lactam antibiotic, suitable for systemic infections such as respiratory system, urinary system, skin and soft tissue caused by sensitive bacteria; potassium clavulanate is a β-lactamase inhibitor, which can compete with β-lactamase - Irreversible binding of lactamase, so that the en...

AI Technical Summary

Problems solved by technology

[0004] The compound amoxicillin orally disintegrating tablet was launched in the United States for the first time, and some units in my country have been developing it for human use, but at present, there is no research and development of this dosage form and product in the veterinary drug market in my country, so there is an urgent need to develop one and one in China A series of veterinary drug products that are convenie