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Amoxicillin oral disintegrating tablet for domestic fowls and preparation method thereof

A technology of orally disintegrating tablets and amoxicillin, applied in the field of compound amoxicillin orally disintegrating tablets for poultry and its preparation, to achieve the effects of less intestinal residue, small weight difference and high bioavailability

Inactive Publication Date: 2010-04-14
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The compound amoxicillin orally disintegrating tablet was launched in the United States for the first time, and some units in my country have been developing it for human use, but at present, there is no research and development of this dosage form and product in the veterinary drug market in my country, so there is an urgent need to develop one and one in China A series of veterinary drug products that are convenient for administration, do not require water supply, fast absorption, high bioavailability, administration method, good taste, less intestinal residues, low side effects, avoid the first-pass effect of the liver, or require only a small amount of water and do not need to be chewed, To make up for the gap in dosage forms in the domestic veterinary drug market, and open up a new way for the treatment of poultry-specific drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A compound amoxicillin orally disintegrating tablet for poultry, its constituents and parts by weight are respectively (according to the ratio of raw and auxiliary materials per 1000 compound amoxicillin orally disintegrating tablets, the same as in the following examples):

[0033] Amoxicillin 250g

[0034] Potassium Clavulanate 62.5g

[0035] Microcrystalline Cellulose 85g

[0036] Low-substituted hydroxypropyl cellulose (L-HPC) 20g

[0037] Lactose 40g

[0038] Aspartame 25g

[0039] Fresh Milk King Flavor 15g

[0040] Sodium saccharin 0.5g

[0041] Magnesium Stearate 1.5g.

[0042] The bulk drug of the compound amoxicillin orally disintegrating tablet involved in the present invention is amoxicillin and clavulanate potassium, and its amoxicillin chemical name is: (2S, 5R, 6R)-3,3-dimethyl- 6-[(R)-(-)-2-amino-2-(4-hydroxyphenyl)acetamido]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane- 2-Formic acid trihydrate, potassium clavulanate chemical name is: (Z)-(2S,5R)-3-(...

Embodiment 2

[0052] A compound amoxicillin orally disintegrating tablet for poultry, its constituents and parts by weight are respectively:

[0053] Amoxicillin 500g

[0054] Potassium clavulanate 125g

[0055] Microcrystalline Cellulose 165g

[0056] Low-substituted hydroxypropyl cellulose (L-HPC) 35g

[0057] Lactose 102g

[0058] Aspartame 45g

[0059] Fresh Milk King Flavor 25g

[0060] Sodium saccharin 0.8g

[0061] Magnesium Stearate 2.8g.

[0062] The steps of the preparation method of this embodiment are the same as those in Example 1.

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PUM

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Abstract

The invention relates to an amoxicillin oral disintegrating tablet for domestic fowls and a preparation method thereof, wherein the composing components of the amoxicillin oral disintegrating tablet and the parts by weight thereof are respectively that 300-800 parts of amoxicillin, 100-150 parts of clavulanate potassium, 140-200 parts of microcrystalline cellulose, 20-60 parts of low-substituted hydroxypropyl cellulose, 60-120 parts of lactose, 30-80 parts of esibatan, 10-50 parts of milk king essence, 0.5-1.5 parts of saccharin sodium, and 1.5-5 parts of magnesium stearate. The amoxicillin oral disintegrating tablet has the advantages that manufacturing devices are simple, the operation is easy, the weight difference is small, and the cost is low, and breaks the conventional rule of just using freeze-dry technology to produce oral disintegrating tablets, opens up the technology for producing the oral disintegrating tablet just through adopting common powder type granule tablets in China, is an important breakthrough of the processing technology of preparations for oral use in China, and opens new possibilities in emergency treatment of animal drug markets in China.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a compound amoxicillin orally disintegrating tablet for poultry and a preparation method thereof. Background technique [0002] With the rapid development of my country's poultry breeding industry and the continuous development of veterinary drug research, the application of antibiotics in the treatment of various diseases and infections of poultry has become common, which has played a positive role in improving the survival rate and health level of poultry and disease treatment. Maximizing the effectiveness of antibiotics to control disease has always been a challenge. Amoxicillin is a β-lactam antibiotic, suitable for systemic infections such as respiratory system, urinary system, skin and soft tissue caused by sensitive bacteria; potassium clavulanate is a β-lactamase inhibitor, which can compete with β-lactamase - Irreversible binding of lactamase, so that the en...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/43A61K47/38A61P31/04
Inventor 要瑞丽聂江力裴毅元军英
Owner TIANJIN BIJIA PHARMA CO LTD
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