Amoxicillin oral disintegrating tablet for domestic fowls and preparation method thereof
A technology of orally disintegrating tablets and amoxicillin, applied in the field of compound amoxicillin orally disintegrating tablets for poultry and its preparation, to achieve the effects of less intestinal residue, small weight difference and high bioavailability
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Embodiment 1
[0032] A compound amoxicillin orally disintegrating tablet for poultry, its constituents and parts by weight are respectively (according to the ratio of raw and auxiliary materials per 1000 compound amoxicillin orally disintegrating tablets, the same as in the following examples):
[0033] Amoxicillin 250g
[0034] Potassium Clavulanate 62.5g
[0035] Microcrystalline Cellulose 85g
[0036] Low-substituted hydroxypropyl cellulose (L-HPC) 20g
[0037] Lactose 40g
[0038] Aspartame 25g
[0039] Fresh Milk King Flavor 15g
[0041] Magnesium Stearate 1.5g.
[0042] The bulk drug of the compound amoxicillin orally disintegrating tablet involved in the present invention is amoxicillin and clavulanate potassium, and its amoxicillin chemical name is: (2S, 5R, 6R)-3,3-dimethyl- 6-[(R)-(-)-2-amino-2-(4-hydroxyphenyl)acetamido]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane- 2-Formic acid trihydrate, potassium clavulanate chemical name is: (Z)-(2S,5R)-3-(...
Embodiment 2
[0052] A compound amoxicillin orally disintegrating tablet for poultry, its constituents and parts by weight are respectively:
[0053] Amoxicillin 500g
[0054] Potassium clavulanate 125g
[0055] Microcrystalline Cellulose 165g
[0056] Low-substituted hydroxypropyl cellulose (L-HPC) 35g
[0057] Lactose 102g
[0058] Aspartame 45g
[0059] Fresh Milk King Flavor 25g
[0061] Magnesium Stearate 2.8g.
[0062] The steps of the preparation method of this embodiment are the same as those in Example 1.
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