Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier
A blood-brain barrier and ultrasound system technology, applied in the field of medical devices, can solve problems such as no research reports, no ultrasound array and control parameters involved, and no accurate focusing of low-frequency ultrasound through the skull, so as to avoid damage.
Inactive Publication Date: 2010-04-28
XI AN JIAOTONG UNIV
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The invention discloses a system for enforcing medicaments to permeate a blood brain barrier by enforcing the blood brain barrier to be opened. A computer control system adjusts the phase and amplitude of each piezoelectric crystal drive signal to enable the ultrasonic radiation in special power to be generated at a brain lesion, so that the blood brain barrier on the brain lesion is effectively led to be opened, macromolecular medicaments are enforced to permeate the blood brain barrier and the effective medicament concentration is achieved at the lesion; and researches show that when the ultrasonic radiation stops, the blood brain barrier can restore the normal function after a dozen of hours. The system for enforcing medicaments to permeate the blood brain barrier has the advantages of non-invasiveness, controllability, safety, no cytotoxicity and good positioning and targeting characteristics, and can effectively prevent the functions from being interfered when the blood brain barrier is normal and protect the brain environment, and the invention creates a new path for medicament and gene therapies of central nervous system diseases.
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Property | Measurement | Unit |
Pulse width | 100.0 | ms |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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