Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier

A blood-brain barrier and ultrasound system technology, applied in the field of medical devices, can solve problems such as no research reports, no ultrasound array and control parameters involved, and no accurate focusing of low-frequency ultrasound through the skull, so as to avoid damage.

Inactive Publication Date: 2010-04-28
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

In 2005, Hynynen et al. used low-frequency ultrasound suitable for penetrating the skull to study the living rabbit brain, analyzed more biological data, and further confirmed the effective and controllable effect of low-frequency ultrasound on opening the blood-brain barrier. However, this experiment was carried out on the open skull window, and his research has not yet involved the technology of accurate focusing of low-frequency ultrasound passing through the skull, as well a

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  • Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier
  • Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier
  • Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier

Examples

Experimental program
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Example Embodiment

[0028] Example 1. Composition and mode of action to promote the penetration of drugs through the blood-brain barrier system

[0029] Such as figure 1 As shown, the conformal ultrasound system that promotes the penetration of drugs through the blood-brain barrier is mainly composed of a central computer 1 and a phased-array ultrasound transmitter 7. The phased-array ultrasound transmitter 7 is composed of 512 ultrasound transmitters. Each ultrasound transmitter The unit is composed of a single-chip microcomputer system 2, a high-frequency excitation unit 3, a power amplifier 4, a coupling unit 5 and a phased array piezoelectric array element 6. The single-chip system 2 controls the high-frequency excitation unit 3 to synthesize high-frequency sine waves or high-frequency square waves. The high-frequency sine waves or high-frequency square waves can be generated by a digital frequency synthesizer, or can be generated by an LC self-excited oscillation circuit, and a power amplifier ...

Example Embodiment

[0045] Example 2. Methods of using drugs to promote the penetration of the blood-brain barrier system

[0046] First, let the patient lie on a horizontally movable bed, wear a hat-shaped water bag on the head, and then send the patient into the treatment area of ​​the instrument.

[0047] When the patient is lying flat, activate the MRI transmitter device in the MRI auxiliary monitoring system 9, receive the brain function image from the MRI receiver device, and transmit the brain function information to the center through the MRI signal processing and imaging unit computer.

[0048] The doctor checks the location of the lesion on the computer and clicks on the mouse to determine the location of the lesion.

[0049] The driver 8 is used to move the phased array ultrasound transmitter 7 to the ideal treatment site to emit ultrasound; then the central computer 1 calculates the spatial distance of the current ultrasound probe element relative to the lesion, and the delay corresponding to...

Example Embodiment

[0054] Example 3, the therapeutic effect of promoting drugs to penetrate the blood-brain barrier system

[0055] The effect display is divided into two parts: in vitro experiment and in vivo experiment.

[0056] The establishment of an in vitro blood-brain barrier model was achieved by co-cultivating white rabbit brain microvascular endothelial cells and astrocytes. Studies have proved that under specific ultrasound parameters, ultrasound can significantly increase the permeability of cell membranes, allowing macromolecular gene drugs to enter the cell for expression, with a transfection rate of 40%, the intensity of gene expression in the cell and the amount of specific control parameters It is closely related to the conclusion that it can be safely used for gene delivery under a precise effect scale control system. Figure 5 It can be seen that through scanning electron microscopy, the repairable micropores on the S180 cell membrane caused by ultrasound, that is, ultrasound opens...

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Abstract

The invention discloses a system for enforcing medicaments to permeate a blood brain barrier by enforcing the blood brain barrier to be opened. A computer control system adjusts the phase and amplitude of each piezoelectric crystal drive signal to enable the ultrasonic radiation in special power to be generated at a brain lesion, so that the blood brain barrier on the brain lesion is effectively led to be opened, macromolecular medicaments are enforced to permeate the blood brain barrier and the effective medicament concentration is achieved at the lesion; and researches show that when the ultrasonic radiation stops, the blood brain barrier can restore the normal function after a dozen of hours. The system for enforcing medicaments to permeate the blood brain barrier has the advantages of non-invasiveness, controllability, safety, no cytotoxicity and good positioning and targeting characteristics, and can effectively prevent the functions from being interfered when the blood brain barrier is normal and protect the brain environment, and the invention creates a new path for medicament and gene therapies of central nervous system diseases.

Description

Technical field: [0001] The invention relates to the field of medical equipment, in particular to a conformable ultrasonic system for promoting medicine to pass through the blood-brain barrier. Background technique: [0002] The following describes the prior art related to the present invention from the domestic research status and the foreign research status. [0003] Domestic researches on cross-blood-brain-barrier drug delivery, such as Liu Qiang from Tangdu Hospital of Fourth Military Medical University, conducted research on protein transduction-mediated macromolecular proteins passing through the blood-brain barrier and their distribution in brain tissue ( Chinese Journal of Modern Medicine, 2003, 3(5): 33-35), Yizhao Chen of the First Military Medical University, Research on the Effect of High Temperature on the Tight Junction Between Endothelial Cells of the Blood Brain Barrier and Its Molecular Mechanism, Hebei Yiling Medical Research Institute of Zhao Baosheng et ...

Claims

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Application Information

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IPC IPC(8): A61N7/00A61M37/00A61B5/055
Inventor 周秦武张大龙丁钊蒋鹏程陈竣虹
Owner XI AN JIAOTONG UNIV
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