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Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier

A blood-brain barrier and ultrasound system technology, applied in the field of medical devices, can solve problems such as no research reports, no ultrasound array and control parameters involved, and no accurate focusing of low-frequency ultrasound through the skull, so as to avoid damage.

Inactive Publication Date: 2010-04-28
XI AN JIAOTONG UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

In 2005, Hynynen et al. used low-frequency ultrasound suitable for penetrating the skull to study the living rabbit brain, analyzed more biological data, and further confirmed the effective and controllable effect of low-frequency ultrasound on opening the blood-brain barrier. However, this experiment was carried out on the open skull window, and his research has not yet involved the technology of accurate focusing of low-frequency ultrasound passing through the skull, as well as the heat accumulation when the ultrasound passes through the skull and the resulting damage to the skin of the head and adjacent areas. Effects on brain tissue within the skull
[0006] In short, the current foreign related research is still in the preliminary stage of observation of physical and chemical phenomena and the mechanism of drug delivery across the blood-brain barrier. Stacking issues, ultrasound arrays used in this study and control parameters have not been addressed

Method used

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  • Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier
  • Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier
  • Conformal ultrasonic system for enforcing medicaments to permeate blood brain barrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, promoting the composition and mode of action of drugs through the blood-brain barrier system

[0029] Such as figure 1 As shown, the conformal ultrasound system for promoting drugs to pass through the blood-brain barrier is mainly composed of a central computer 1 and a phased array ultrasound emitting device 7. The phased array ultrasound transmitting device 7 is composed of 512 ultrasound emitting units, and each ultrasound emitting The unit is composed of a single-chip microcomputer system 2, a high-frequency excitation unit 3, a power amplifier 4, a coupling unit 5 and a phased array piezoelectric array element 6. The single-chip system 2 controls the high-frequency excitation unit 3 to synthesize high-frequency sine waves or high-frequency square waves. High-frequency sine waves or high-frequency square waves can be generated by digital frequency synthesizers, or by LC self-excited oscillation circuits, and then passed through power amplifiers. 4 Ampl...

Embodiment 2

[0045] Embodiment 2, the use method that promotes medicine to pass through the blood-brain barrier system

[0046] First let the patient lie flat on a horizontally movable bed with a cap-shaped water bag on his head, and then send the patient into the instrument treatment area.

[0047] When the patient is lying flat, start the nuclear magnetic resonance emission device in the nuclear magnetic resonance imaging auxiliary monitoring system 9, and the brain function image is received by the nuclear magnetic resonance receiving device, and the brain function information is transmitted to the central through the nuclear magnetic resonance signal processing and imaging unit. computer.

[0048] The doctor checks the location of the lesion on the computer, and clicks the mouse to determine the spatial position of the lesion.

[0049] The driver 8 is used to move the phased array ultrasonic emitting device 7 to emit ultrasonic waves to the ideal treatment site; then the central compu...

Embodiment 3

[0054] Embodiment 3, promoting the therapeutic effect of medicine through the blood-brain barrier system

[0055] The effect display is divided into two parts: in vitro experiment and in vivo experiment.

[0056] The establishment of the blood-brain barrier model in vitro was achieved by co-culturing rabbit brain microvascular endothelial cells and astrocytes. Studies have proved that under specific ultrasonic parameters, ultrasonic waves can significantly increase the permeability of cell membranes, allowing macromolecular gene drugs to enter cells and express them. The transfection rate is 40%. The intensity of gene expression in cells and the amount of specific control parameters closely related, leading to the conclusion that it can be safely used for gene delivery under the precise effect scale control system, from Figure 5 It can be seen that through the scanning electron microscope, the repairable micropores on the S180 cell membrane caused by the action of ultrasound...

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Abstract

The invention discloses a system for enforcing medicaments to permeate a blood brain barrier by enforcing the blood brain barrier to be opened. A computer control system adjusts the phase and amplitude of each piezoelectric crystal drive signal to enable the ultrasonic radiation in special power to be generated at a brain lesion, so that the blood brain barrier on the brain lesion is effectively led to be opened, macromolecular medicaments are enforced to permeate the blood brain barrier and the effective medicament concentration is achieved at the lesion; and researches show that when the ultrasonic radiation stops, the blood brain barrier can restore the normal function after a dozen of hours. The system for enforcing medicaments to permeate the blood brain barrier has the advantages of non-invasiveness, controllability, safety, no cytotoxicity and good positioning and targeting characteristics, and can effectively prevent the functions from being interfered when the blood brain barrier is normal and protect the brain environment, and the invention creates a new path for medicament and gene therapies of central nervous system diseases.

Description

Technical field: [0001] The invention relates to the field of medical equipment, in particular to a conformable ultrasonic system for promoting medicine to pass through the blood-brain barrier. Background technique: [0002] The following describes the prior art related to the present invention from the domestic research status and the foreign research status. [0003] Domestic researches on cross-blood-brain-barrier drug delivery, such as Liu Qiang from Tangdu Hospital of Fourth Military Medical University, conducted research on protein transduction-mediated macromolecular proteins passing through the blood-brain barrier and their distribution in brain tissue ( Chinese Journal of Modern Medicine, 2003, 3(5): 33-35), Yizhao Chen of the First Military Medical University, Research on the Effect of High Temperature on the Tight Junction Between Endothelial Cells of the Blood Brain Barrier and Its Molecular Mechanism, Hebei Yiling Medical Research Institute of Zhao Baosheng et ...

Claims

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Application Information

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IPC IPC(8): A61N7/00A61M37/00A61B5/055
CPCA61M37/0092
Inventor 周秦武张大龙丁钊蒋鹏程陈竣虹
Owner XI AN JIAOTONG UNIV
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