Synthesis method of 2-pyridine formaldoxime

A synthetic method, the technology of pyridine formaldehyde, applied in the direction of organic chemistry, etc., can solve the problems of long steps, low yield, long time consumption, etc., and achieve the effect of short production time, high yield and simple process
CN101698659AInactive Publication Date: 2010-04-28董婧
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
董婧
Publication Date
2010-04-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthesis method of 2-pyridine formaldoxime, comprising the following steps: firstly mixing 2-methyl pyridine, glacial acetic acid and hydrogen peroxide for heating, reacting at the temperature of 60-70 DEG C for 3-5 hours; secondly, adding hydrogen peroxide, continuously reacting for 5-8 hours, and then separating and purifying to obtain the nitric oxide of 2-methyl pyridine; thirdly, adding alcohol, concentrated sulfuric acid into the nitric oxide of 2-methyl pyridine to carry out nitritation reaction on sodium nitrite to obtain sodium salt, and then using concentrated hydrochloric acid to neutralize alcohol solution to pH=3-4, filtering out sodium chloride, reducing the pressure of filter liquor and then concentrating to recover alcohol so as to obtain the pralidoxime chloride crude product, then dissolving by distilled water, and carrying out active carbon decoloration and recrystallization to obtain the finished product. The invention has simple process, short production time, high yield and easy realization of industrialization.
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Description

technical field

[0001] The invention relates to a compound synthesis method, in particular to a synthesis method of 2-pyridine formaldehyde oxime. Background technique

[0002] After organophosphate poisoning, the cholinesterase in the body is phosphorylated by the poison to form a relatively stable phosphorylated cholinesterase. Lose the ability to hydrolyze acetylcholine, resulting in symptoms of poisoning. Organophosphate antidotes widely used in clinic can reactivate poisoned phosphorylated cholinesterase, and 2-pyridine formaldehyde oxime is an important synthetic intermediate for the preparation of organophosphate antidotes. The currently reported synthetic method of 2-pyridinecarbaldehyde oxime has long steps, low yield and long time consumption. The synthesis method reported in the present invention not only significantly saves production time, but also has simple process and greatly improved yield. Contents of the invention

[0003] The technical problem to be ...

Claims

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