Nano fiber artificial blood vessel for catalyzing and releasing nitric oxide and preparation method
A nanofiber and nitric oxide technology is applied in the biomedical application field of polymer materials, which can solve the problems of cumbersome preparation, poor controllability, inability to control NO release for a long time, etc. The effect of platelet aggregation
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Embodiment 1
[0037] A nanofiber artificial blood vessel that catalyzes the release of nitric oxide is composed of a three-dimensional mesh non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:
[0038] (1) gelatin is dissolved in glacial acetic acid to make a solution with a mass concentration of 20%;
[0039] (2) Take 20mL of the solution prepared in step (1), add 8mL of heparin sodium aqueous solution with a mass concentration of 2.0% to make a spinning stock solution, put it into an electrospinning equipment, and use the electrospinning method to electrospin The fibers ejected and shaped by the spinning nozzle in the equipment are collected on the collection roller to form a nanofiber non-woven film tube;
[0040] (3) Polyurethane CorethaneTM and copper salt chelate are dissolved in a mass ratio of 100: 0.05 in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide in a mass ratio of 100: 0.05 to make polyure...
Embodiment 2
[0043] A nanofiber artificial blood vessel that catalyzes the release of nitric oxide is composed of a three-dimensional mesh non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:
[0044] (1) gelatin is dissolved in glacial acetic acid to make a solution with a mass concentration of 20%;
[0045] (2) Take 20mL of the solution prepared in step (1), add 8mL of heparin sodium aqueous solution with a mass concentration of 2.0% to make a spinning stock solution, put it into an electrospinning equipment, and use the electrospinning method to electrospin The fibers ejected and shaped by the spinning nozzle in the equipment are collected on the collection roller to form a nanofiber non-woven film tube;
[0046] (3) Polyurethane CorethaneTM and copper salt chelate are dissolved in a mass ratio of 100: 0.1 in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide in a mass ratio of 100: 0.1 to make polyureth...
Embodiment 3
[0049] A nanofiber artificial blood vessel that catalyzes the release of nitric oxide is composed of a three-dimensional mesh non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:
[0050] (1) gelatin is dissolved in glacial acetic acid to make a solution with a mass concentration of 20%;
[0051] (2) Take 20mL of the solution prepared in step (1), add 8mL of heparin sodium aqueous solution with a mass concentration of 2.0% to make a spinning stock solution, put it into an electrospinning equipment, and use the electrospinning method to electrospin The fibers ejected and shaped by the spinning nozzle in the equipment are collected on the collection roller to form a nanofiber non-woven film tube;
[0052] (3) Polyurethane CorthaneTM and copper salt chelate are dissolved in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide with a mass ratio of 100: 0.2 in a mass ratio to make polyurethane mass T...
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