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Nano fiber artificial blood vessel for catalyzing and releasing nitric oxide and preparation method

A nanofiber and nitric oxide technology is applied in the biomedical application field of polymer materials, which can solve the problems of cumbersome preparation, poor controllability, inability to control NO release for a long time, etc. The effect of platelet aggregation

Active Publication Date: 2010-05-12
南通双辉医疗器械科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of the existing NO release blood contact materials is cumbersome and difficult, and the blood contact materials still only have a fixed NO storage capacity, so the continuous long-term release of NO is limited, and the NO release cannot be controlled for a long time, and the controllability is poor.

Method used

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  • Nano fiber artificial blood vessel for catalyzing and releasing nitric oxide and preparation method
  • Nano fiber artificial blood vessel for catalyzing and releasing nitric oxide and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0037] A nanofiber artificial blood vessel that catalyzes the release of nitric oxide is composed of a three-dimensional mesh non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:

[0038] (1) gelatin is dissolved in glacial acetic acid to make a solution with a mass concentration of 20%;

[0039] (2) Take 20mL of the solution prepared in step (1), add 8mL of heparin sodium aqueous solution with a mass concentration of 2.0% to make a spinning stock solution, put it into an electrospinning equipment, and use the electrospinning method to electrospin The fibers ejected and shaped by the spinning nozzle in the equipment are collected on the collection roller to form a nanofiber non-woven film tube;

[0040] (3) Polyurethane CorethaneTM and copper salt chelate are dissolved in a mass ratio of 100: 0.05 in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide in a mass ratio of 100: 0.05 to make polyure...

Embodiment 2

[0043] A nanofiber artificial blood vessel that catalyzes the release of nitric oxide is composed of a three-dimensional mesh non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:

[0044] (1) gelatin is dissolved in glacial acetic acid to make a solution with a mass concentration of 20%;

[0045] (2) Take 20mL of the solution prepared in step (1), add 8mL of heparin sodium aqueous solution with a mass concentration of 2.0% to make a spinning stock solution, put it into an electrospinning equipment, and use the electrospinning method to electrospin The fibers ejected and shaped by the spinning nozzle in the equipment are collected on the collection roller to form a nanofiber non-woven film tube;

[0046] (3) Polyurethane CorethaneTM and copper salt chelate are dissolved in a mass ratio of 100: 0.1 in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide in a mass ratio of 100: 0.1 to make polyureth...

Embodiment 3

[0049] A nanofiber artificial blood vessel that catalyzes the release of nitric oxide is composed of a three-dimensional mesh non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:

[0050] (1) gelatin is dissolved in glacial acetic acid to make a solution with a mass concentration of 20%;

[0051] (2) Take 20mL of the solution prepared in step (1), add 8mL of heparin sodium aqueous solution with a mass concentration of 2.0% to make a spinning stock solution, put it into an electrospinning equipment, and use the electrospinning method to electrospin The fibers ejected and shaped by the spinning nozzle in the equipment are collected on the collection roller to form a nanofiber non-woven film tube;

[0052] (3) Polyurethane CorthaneTM and copper salt chelate are dissolved in a mixed solvent of tetrahydrofuran and N, N-dimethylformamide with a mass ratio of 100: 0.2 in a mass ratio to make polyurethane mass T...

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Abstract

The invention discloses a nano fiber artificial blood vessel for catalyzing and releasing nitric oxide and a preparation method. The artificial blood vessel consists of a three-dimensional reticular non-woven film pipe structure formed by an inner layer and an outer layer of nano fibers. The artificial blood vessel is prepared by the following method comprising the following steps of: dissolving gelatin in glacial acetic acid to prepare a solution; adding a sodium heparin aqueous solution to prepare a spinning dope for electrostatic spinning to form nano fiber non-woven film pipes; dissolving polyurethane and nantokite chelate in a mixed solution of tetrahydrofuran and N,N-dimethyl fomamide to prepare a polyurethane spinning dope; carrying out electrostatic spinning to continue collecting polyurethane fibers on a collecting roller with the nano fiber non-woven film pipes so as to form polyurethane fiber non-woven film pipes; and soaking and treating the polyurethane fiber non-woven film pipes in an aqueous solution of a crosslinking agent. The artificial blood vessel can catalyze and release nitric oxide for a long time in vivo and in vitro and is beneficial to inhibiting the aggregation of platelets. The preparation method is simple, and the crosslinking degree is easy to control.

Description

technical field [0001] The invention belongs to the biomedical application field of polymer materials, and relates to a nanofiber artificial blood vessel and a preparation method. Background technique [0002] Severe damage to human blood vessels has become a difficult problem in the medical field due to poor self-repair ability. Since the clinical success of artificial blood vessels made of vinylon in 1952, people have successively developed artificial blood vessels made of various materials. The commonly used transplanted blood vessels are mainly made of materials such as polyester, nylon and polytetrafluoroethylene, but these materials do not support the adhesion and growth of human endothelial cells, making it difficult to fully endothelialize the blood vessels implanted in the human body, and have a negative effect on the blood vessels. Long-term adaptation creates barriers. Therefore, this type of blood vessel can only be used as a substitute for diseased blood vessel...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/24A61L27/22A61L27/18D01D5/00D01D1/02
Inventor 冯亚凯郭锦棠肖若芳
Owner 南通双辉医疗器械科技有限公司
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