Composite superfine fibre membrane of biologic compatible shell core structure and preparation method thereof

A shell-core structure and ultra-fine fiber technology, which can be used in fiber treatment, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems that drugs cannot be released separately, achieve good biocompatibility, simple method, The effect of broad application prospects

Active Publication Date: 2010-05-12
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on electrospun polymer fibers as drug-loading materials mostly focuses on how to increase the drug loading, how to precisely control drug release, prevent drug burst release, etc., that is, the research is mostly limited to the use of polymer fibers to load and releas

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) 10g polycaprolactone (PCL) is dissolved in 90g tetrahydrofuran, is mixed with the PCL solution that mass percent concentration is 10%, for subsequent use;

[0020] (2) 9ml of 15% by mass concentration of methyl methacrylate aqueous solution and 1ml of 20% by mass percent concentration of vinyl ethylene glycol dimethacrylate were mixed to obtain solution I for subsequent use;

[0021] (3) 100ml of mass percentage concentration is 1% methyl-beta-cyclodextrin aqueous solution heating and kept on 70 DEG C, then add 0.3g potassium persulfate and stir well, then slowly drop step (2) wherein ) the solution I obtained, stirred while adding dropwise, after 4 to 5 hours, the solution I was all added dropwise, continued to stir for 1 hour, and finally centrifuged at a speed of 3000r / min for 2min, and the centrifuged product was washed with deionized water and then centrifuged , repeating the steps of washing-centrifugation three times to obtain cross-linked PMMA colloids for s...

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PUM

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Abstract

The invention provides a composite superfine fibre membrane material of a biologic compatible shell core structure and a preparation method thereof. The composite superfine fibre of the biologic compatible shell core structure, which comprises 20-95% of shell layer biomacromolecule by mass percent and 5-80% of core layer colloid by mass percent, is mainly prepared by utilizing an electrostatic spinning method with simple and easy operation. The composite superfine fibre membrane material of the biologic compatible shell core structure has light and flexible quality, good air permeability and favorable biologic compatibility, biologic degradability and biologic absorptivity, can be used as an active medicine carrier material, can completely package various active medicines, realize the independent controlled release of various medicines and has extensive application prospect in the aspects of tissue engineering bracket materials, wound coating materials, artificial dressings, multi-functional composite membranes and the like.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a biocompatible shell core structure composite superfine fiber membrane material and a preparation method thereof. Background technique [0002] High-molecular polymers can be used as drug-loading materials, especially polymer fibers prepared by electrospinning, whose diameters are generally in the nanometer to micron-scale, have a high drug load, and can be biodegraded and absorbed. It is currently the most widely used drug-loaded material. At present, the research on electrospun polymer fibers as drug-loading materials mostly focuses on how to increase the drug loading, how to precisely control drug release, prevent drug burst release, etc., that is, the research is mostly limited to the use of polymer fibers to load and release a single drug. ; Although there are currently attempts to use multi-channel fibers to load multiple drugs at the same time, due to the constant fiber ...

Claims

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Application Information

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IPC IPC(8): D01F8/16D01F8/10D01F8/14C08F220/14C08F220/54D01D5/34A61K47/32A61K47/34A61L27/44A61L27/58A61L15/26A61L15/24A61L15/42
Inventor 韩志超许杉杉申孟芝李立藏
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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