Composite superfine fibre membrane of biologic compatible shell core structure and preparation method thereof

Abstract

The invention provides a composite superfine fibre membrane material of a biologic compatible shell core structure and a preparation method thereof. The composite superfine fibre of the biologic compatible shell core structure, which comprises 20-95% of shell layer biomacromolecule by mass percent and 5-80% of core layer colloid by mass percent, is mainly prepared by utilizing an electrostatic spinning method with simple and easy operation. The composite superfine fibre membrane material of the biologic compatible shell core structure has light and flexible quality, good air permeability and favorable biologic compatibility, biologic degradability and biologic absorptivity, can be used as an active medicine carrier material, can completely package various active medicines, realize the independent controlled release of various medicines and has extensive application prospect in the aspects of tissue engineering bracket materials, wound coating materials, artificial dressings, multi-functional composite membranes and the like.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a biocompatible shell core structure composite superfine fiber membrane material and a preparation method thereof. Background technique [0002] High-molecular polymers can be used as drug-loading materials, especially polymer fibers prepared by electrospinning, whose diameters are generally in the nanometer to micron-scale, have a high drug load, and can be biodegraded and absorbed. It is currently the most widely used drug-loaded material. At present, the research on electrospun polymer fibers as drug-loading materials mostly focuses on how to increase the drug loading, how to precisely control drug release, prevent drug burst release, etc., that is, the research is mostly limited to the use of polymer fibers to load and release a single drug. ; Although there are currently attempts to use multi-channel fibers to load multiple drugs at the same time, due to the constant fiber ...

AI Technical Summary

Problems solved by technology

At present, the research on electrospun polymer fibers as drug-loading materials mostly focuses on how to increase the drug loading, how to precisely control drug release, prevent drug burst release, etc., that is, the research is mostly limited to the use of polymer fibers to load and release a single drug. ;Although there are currently attempts to use multi-channel fibers to load multiple drugs at the same time, due to the constant fiber diameter and constant degradation rate, although different drugs can be loaded in different channels, the drugs cannot be released separately.