Colchicine bilayer sustained-release tablet and preparing method thereof

A technology for colchicine and sustained-release tablets, which is applied in the field of colchicine double-layer sustained-release tablets and its preparation, can solve the problems that the cumulative release rate cannot meet the requirements of the Pharmacopoeia, and cannot better solve the problems of multiple administrations, etc. Achieve uniform and effective blood drug concentration, reduce the number of medications, and reduce the effects of toxic and side effects
CN101732274AInactive Publication Date: 2010-06-16普尔药物科技开发(深圳)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
普尔药物科技开发(深圳)有限公司
Publication Date
2010-06-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a colchicine bilayer sustained-release tablet which comprises a quick release layer and a sustained-release layer, wherein the quick release layer mainly consists of colchicine, a disintegrant, a filler, a lubricant and an adhesive; the sustained-release tablet mainly consists of colchicine, a sustained-release matrix, a retarding agent, a filler and an adhesive; the weight ratio of the colchicine in the quick release layer to the colchicine in the sustained-release layer is (0.25-0.42) : 1; and the weight ratio of the quick release layer to the sustained-release layer is 1: 2 to 1: 4. The invention also discloses a method for preparing the colchicine bilayer sustained-release tablet. The colchicine bilayer sustained-release tablet releases the drugs through the quick release layer to quickly achieve the effective blood drug concentration, slowly releases the drugs through the sustained-release layer to exert and sustain the stable and uniform effective blood drug concentration, reduces the drug taking times and lightens the toxic or side function.
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Description

technical field

[0001] The invention relates to a pharmaceutical composition containing colchicine and a preparation method thereof, in particular to a colchicine immediate-release and sustained-release double-layer preparation and a preparation method thereof. Background technique

[0002] Colchicine is a tropolone alkaloid, which was first isolated from the corm of Colchicum autumnale L., a plant of the Liliaceae family in Europe. Its appearance is light yellow crystalline powder, and the color becomes dark when exposed to light. Slightly soluble in water, easily soluble in ethanol or chloroform. Colchicine has significant biological activity, mainly anti-inflammatory, anti-tumor, anti-fibrosis and other pharmacological effects. Recurrent pericarditis, Bechet's disease, etc. also have good curative effect. Among them, colchicine is a specific drug for the treatment of acute attacks of gout. It was used to treat the attacks of gout as early as 1763, and it is still the m...

Claims

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